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One year mortality outcomes from the ACTA trial of cryptococcal meningitis treatment in Malawi

Kanyama, C; Molloy, SF; Chan, AK; Lupiya, D; Chawinga, C; Adams, J; Bright, P; Lalloo, DG; Heyderman, RS; Lortholary, O; et al. Kanyama, C; Molloy, SF; Chan, AK; Lupiya, D; Chawinga, C; Adams, J; Bright, P; Lalloo, DG; Heyderman, RS; Lortholary, O; Jaffar, S; Loyse, A; van Oosterhout, JJ; Hosseinipour, MC; Harrison, TS (2019) One year mortality outcomes from the ACTA trial of cryptococcal meningitis treatment in Malawi. CLINICAL INFECTIOUS DISEASES. ISSN 1058-4838 https://doi.org/10.1093/cid/ciz454
SGUL Authors: Molloy, Sile

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Abstract

In Malawi, 236 participants from the ACTA cryptococcal meningitis treatment trial were followed-up for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericinB plus flucytosine was associated with the lowest 1 year mortality (27.5% [95%CI: 16.3 to 44.1]).

Item Type: Article
Additional Information: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: 06 Biological Sciences, 11 Medical And Health Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: CLINICAL INFECTIOUS DISEASES
ISSN: 1058-4838
Dates:
DateEvent
1 June 2019Published Online
21 May 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
100504Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
ANRS12275French Agency for Research on AIDS and Viral HepatitisUNSPECIFIED
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/110884
Publisher's version: https://doi.org/10.1093/cid/ciz454

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