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Artemisinins: their growing importance in medicine

Krishna, S; Bustamante, L; Haynes, RK; Staines, HM (2008) Artemisinins: their growing importance in medicine. TRENDS IN PHARMACOLOGICAL SCIENCES, 29 (10). 520 - 527. ISSN 0165-6147 https://doi.org/10.1016/j.tips.2008.07.004
SGUL Authors: Krishna, Sanjeev Staines, Henry Michael

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Abstract

Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis. More recently, they have also shown potent and broad anticancer properties in cell lines and animal models. In this review, we discuss recent advances in defining the role of artemisinins in medicine, with particular focus on their controversial mechanisms of action. This safe and cheap drug class that saves lives at risk from malaria can also have important potential in oncology.

Item Type: Article
Additional Information: Copyright © 2008 Elsevier Ltd. Under a Creative Commons license CC BY 3.0
Keywords: Animals, Antimalarials, Antineoplastic Agents, Antiparasitic Agents, Artemisia, Artemisinins, Drug Resistance, Humans, Malaria, Falciparum, Neoplasms, Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, ENDOTHELIAL GROWTH-FACTOR, EXPERIMENTAL RHEUMATOID-ARTHRITIS, ANTIMALARIAL AGENT ARTESUNATE, SEVERE FALCIPARUM-MALARIA, HUMAN CANCER-CELLS, NF-KAPPA-B, PLASMODIUM-FALCIPARUM, IN-VITRO, INHIBITS ANGIOGENESIS, PNEUMOCYSTIS-CARINII
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: TRENDS IN PHARMACOLOGICAL SCIENCES
ISSN: 0165-6147
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Dates:
DateEvent
1 October 2008Published
Web of Science ID: WOS:000260552500006
Download EPMC Full text (HTML)
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/34
Publisher's version: https://doi.org/10.1016/j.tips.2008.07.004

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