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Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women

Jefferis, BJ; Lowe, GD; Welsh, P; Rumley, A; Lawlor, DA; Ebrahim, S; Carson, C; Doig, M; Feyerabend, C; McMeekin, L; et al. Jefferis, BJ; Lowe, GD; Welsh, P; Rumley, A; Lawlor, DA; Ebrahim, S; Carson, C; Doig, M; Feyerabend, C; McMeekin, L; Wannamethee, SG; Cook, DG; Whincup, PH (2010) Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women. ATHEROSCLEROSIS, 208 (2). 550 - 556. ISSN 0021-9150 https://doi.org/10.1016/j.atherosclerosis.2009.07.044
SGUL Authors: Cook, Derek Gordon Whincup, Peter Hynes

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Abstract

Aims Secondhand smoke (SHS) exposure is associated with elevated CHD risks. Yet the pathways through which this may operate have not been investigated in epidemiologic studies with objective SHS exposure measures and a wide range of CHD risk factors associated with active smoking. Therefore we investigate associations between SHS exposure and CHD risk factors, to clarify how SHS exposure may raise risk of CHD. Methods Cross-sectional population-based study of 5029 men and women aged 59–80 years from primary care practices in Great Britain. Smoking, behavioural and demographic information was reported in questionnaires; nurses made physical measurements and took blood samples for analysis of serum cotinine and markers of inflammation, hemostasis and endothelial dysfunction. Results Active cigarette smokers had lower albumin and higher triglycerides, CRP, IL-6, white cell count, fibrinogen, blood viscosity, factor VIII, VWF and t-PA than non-smokers. Among non-smokers, serum cotinine levels were independently positively associated with CRP, fibrinogen, factor VIII, VWF and t-PA and inversely associated with albumin, after adjustment for age, gender, social and behavioural factors. The differences in CRP, fibrinogen and albumin between cotinine ≤0.05 and >0.7 ng/ml were one-third to one half the size of differences between cotinine ≤0.05 ng/ml and current smokers, but were of similar magnitude for VWF and t-PA. Conclusions Endothelial, inflammatory and haemostatic markers related to CHD risk showed independent associations with SHS exposure in the same direction as those for active smoking. Results aid understanding of the associations between SHS exposure and elevated CHD risks.

Item Type: Article
Additional Information: Copyright © 2010 Elsevier Ireland Ltd. Under a Creative Commons license CC BY-NC-ND 3.0
Keywords: Aged, Aged, 80 and over, Blood Pressure, Body Mass Index, Cardiovascular Diseases, Cotinine, Female, Hemostasis, Humans, Inflammation, Male, Middle Aged, Regression Analysis, Risk, Sex Factors, Tobacco Smoke Pollution, Science & Technology, Life Sciences & Biomedicine, Peripheral Vascular Disease, Cardiovascular System & Cardiology, Secondhand smoke, CVD risk factors, Inflammation, Epidemiology, ENVIRONMENTAL TOBACCO-SMOKE, CORONARY-HEART-DISEASE, TISSUE-PLASMINOGEN ACTIVATOR, C-REACTIVE PROTEIN, PASSIVE SMOKING, CARDIOVASCULAR-DISEASE, RISK-FACTORS, CIGARETTE-SMOKING, YOUNG-ADULTS, COTININE
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: ATHEROSCLEROSIS
ISSN: 0021-9150
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Dates:
DateEvent
1 February 2010Published
Web of Science ID: WOS:000273989200044
Download EPMC Full text (HTML)
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/2606
Publisher's version: https://doi.org/10.1016/j.atherosclerosis.2009.07.044

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