McAllister, SM;
Koesoemadinata, RC;
Santoso, P;
Soetedjo, NNM;
Kamil, A;
Permana, H;
Ruslami, R;
Critchley, JA;
van Crevel, R;
Hill, PC;
et al.
McAllister, SM; Koesoemadinata, RC; Santoso, P; Soetedjo, NNM; Kamil, A; Permana, H; Ruslami, R; Critchley, JA; van Crevel, R; Hill, PC; Alisjahbana, B
(2019)
High tuberculosis incidence among people living with diabetes in Indonesia.
Trans R Soc Trop Med Hyg.
ISSN 1878-3503
https://doi.org/10.1093/trstmh/trz100
SGUL Authors: Critchley, Julia
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Abstract
BACKGROUND: Data regarding the incidence of tuberculosis (TB) among people living with diabetes (PLWD) in TB-endemic settings are scarce. We examined TB incidence among PLWD in Indonesia who had previously been screened for latent TB infection (LTBI) and TB disease. METHODS: PLWD (≥18 y of age) in an urban setting were examined a mean 3.4 y after they had been screened for active TB and LTBI. Data on subsequent TB diagnosis were collected by interview and with chest X-ray, sputum smear and Mycobacterium tuberculosis culture. TB incidence rates were stratified for baseline LTBI status, as determined by the QuantiFERON interferon-gamma release assay (IGRA). RESULTS: Of 590 PLWD, 101 had died and 163 could not be contacted or refused. Among the 326 who were re-examined, 6 (1.8%; 95% confidence interval [CI] 0.7 to 4.0) reported being diagnosed already and a further 5 were diagnosed with active TB (1.5%; 95% CI 0.50 to 3.5). The TB incidence rate was 9.85 (95% CI 4.03 to 15.68) per 1000 person-years. TB incidence was higher among PLWD with baseline LTBI (17.13; 95% CI 5.25 to 29.00/1000 person-years) compared with those without LTBI (4.79; 95% CI -0.63 to 10.21), with an incidence rate ratio of 3.57 (95% CI 0.86 to 20.92; p=0.054). CONCLUSIONS: PLWD with LTBI in Indonesia and similar settings are likely to benefit from TB preventive therapy.
Item Type: | Article | ||||||
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Additional Information: | This is a pre-copyedited, author-produced version of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The version of record Susan M McAllister, Raspati C Koesoemadinata, Prayudi Santoso, Nanny N M Soetedjo, Abdul Kamil, Hikmat Permana, Rovina Ruslami, Julia A Critchley, Reinout van Crevel, Philip C Hill, Bachti Alisjahbana, High tuberculosis incidence among people living with diabetes in Indonesia, Transactions of The Royal Society of Tropical Medicine and Hygiene, , trz100 is available online at: https://doi.org/10.1093/trstmh/trz100 | ||||||
Keywords: | diabetes mellitus, incidence, tuberculosis, 0605 Microbiology, 1108 Medical Microbiology, 1117 Public Health And Health Services, Tropical Medicine | ||||||
SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | ||||||
Journal or Publication Title: | Trans R Soc Trop Med Hyg | ||||||
ISSN: | 1878-3503 | ||||||
Language: | eng | ||||||
Dates: |
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Publisher License: | Publisher's own licence | ||||||
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PubMed ID: | 31711230 | ||||||
Go to PubMed abstract | |||||||
URI: | http://sgultest.da.ulcc.ac.uk/id/eprint/111395 | ||||||
Publisher's version: | https://doi.org/10.1093/trstmh/trz100 |
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