Gorgoulis, V;
Adams, PD;
Alimonti, A;
Bennett, DC;
Bischof, O;
Bishop, C;
Campisi, J;
Collado, M;
Evangelou, K;
Ferberyre, G;
et al.
Gorgoulis, V; Adams, PD; Alimonti, A; Bennett, DC; Bischof, O; Bishop, C; Campisi, J; Collado, M; Evangelou, K; Ferberyre, G; Gil, J; Hara, E; Krizhanovsky, V; Jurk, D; Maier, AB; Narita, M; Niedernhofer, L; Passos, JF; Robbins, PD; Schmitt, CA; Sedivy, J; Vougas, K; von Zglinicki, T; Zhou, D; Serrano, M; Demaria, M
(2019)
Cellular senescence: defining a path forward.
CELL, 179 (4).
pp. 813-827.
ISSN 0092-8674
https://doi.org/10.1016/j.cell.2019.10.005
SGUL Authors: Bennett, Dorothy Catherine
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Restricted to Repository staff only until 31 October 2020. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) |
Abstract
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
Item Type: | Article | |||||||||||||||||||||||||||
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Additional Information: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||||||
Keywords: | 06 Biological Sciences, 11 Medical And Health Sciences, Developmental Biology | |||||||||||||||||||||||||||
SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) | |||||||||||||||||||||||||||
Journal or Publication Title: | CELL | |||||||||||||||||||||||||||
ISSN: | 0092-8674 | |||||||||||||||||||||||||||
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Publisher License: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | |||||||||||||||||||||||||||
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URI: | http://sgultest.da.ulcc.ac.uk/id/eprint/111257 | |||||||||||||||||||||||||||
Publisher's version: | https://doi.org/10.1016/j.cell.2019.10.005 |
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