Turner, P;
Leab, P;
Ly, S;
Sao, S;
Miliya, T;
Heffelfinger, JD;
Batmunkh, N;
Lessa, FC;
Walldorf, JA;
Hyde, TB;
et al.
Turner, P; Leab, P; Ly, S; Sao, S; Miliya, T; Heffelfinger, JD; Batmunkh, N; Lessa, FC; Walldorf, JA; Hyde, TB; Ork, V; Hossain, MS; Gould, KA; Hinds, J; Cooper, BS; Ngoun, C; Turner, C; Day, NPJ
(2019)
Impact of 13-Valent Pneumococcal Conjugate Vaccine on Colonisation and Invasive Disease in Cambodian Children.
Clin Infect Dis.
ISSN 1537-6591
https://doi.org/10.1093/cid/ciz481
SGUL Authors: Gould, Katherine Ann Hinds, Jason
Abstract
BACKGROUND: Cambodia introduced the 13-valent pneumococcal conjugate vaccine (PCV13) in January 2015 using a 3+0 dosing schedule and no catch-up campaign. We investigated the effects of this introduction on pneumococcal colonisation and invasive disease in children aged <5 years. METHODS: Six colonisation surveys were done between January 2014 and January 2018 in children attending the outpatient department of a non-governmental paediatric hospital in Siem Reap. Nasopharyngeal swabs were analysed by phenotypic and genotypic methods to detect pneumococcal serotypes and antimicrobial resistance. Invasive pneumococcal disease (IPD) data for January 2012 - December 2018 were retrieved from hospital databases. Pre-PCV IPD data and pre-/post-PCV colonisation data were modelled to estimate vaccine effectiveness (VE). RESULTS: Comparing 2014 with 2016-2018, and using adjusted prevalence ratios, vaccine effectiveness (VE) estimates for colonisation were 16.6% (95% CI 10.6-21.8) for all pneumococci and 39.2% (26.7-46.1) for vaccine serotype (VT) pneumococci. There was a 26.0% (17.7-33.0) decrease in multi-drug resistant pneumococcal colonisation. IPD incidence was estimated to have declined by 26.4% (14.4-35.8) by 2018, with a decrease of 36.3% (23.8-46.9) for VT IPD and an increase of 101.4% (62.0-145.4) for non-vaccine serotype IPD. CONCLUSIONS: Following PCV13 introduction into the Cambodian immunisation schedule there have been declines in VT pneumococcal colonisation and disease in children aged <5 years. Modelling of dominant serotype colonisation data produced plausible vaccine effectiveness estimates.
Item Type: |
Article
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Additional Information: |
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
Streptococcus pneumoniae, Cambodia, children, colonisation, vaccine, 06 Biological Sciences, 11 Medical And Health Sciences, Microbiology |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Clin Infect Dis |
ISSN: |
1537-6591 |
Language: |
eng |
Dates: |
Date | Event |
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7 June 2019 | Published Online |
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Publisher License: |
Creative Commons: Attribution 4.0 |
Projects: |
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PubMed ID: |
31175819 |
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Go to PubMed abstract |
URI: |
http://sgultest.da.ulcc.ac.uk/id/eprint/110936 |
Publisher's version: |
https://doi.org/10.1093/cid/ciz481 |
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