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Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years.

Elhakeem, A; Cooper, R; Whincup, P; Brage, S; Kuh, D; Hardy, R (2018) Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years. J Am Heart Assoc, 7 (16). e007459. ISSN 2047-9980 https://doi.org/10.1161/JAHA.117.007459
SGUL Authors: Whincup, Peter Hynes

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Abstract

Background We examined associations of objectively measured physical activity ( PA ) and sedentary time with cardiovascular disease biomarkers at age 60 to 64 years. This included investigation of sex differences and the extent to which associations may be mediated by adiposity. Methods and Results Participants were 795 men and 827 women aged 60 to 64 years from the Medical Research Council National Survey of Health and Development. Combined heart rate and movement sensors worn for 5 consecutive days were used to derive overall PA energy expenditure, kJ /kg per day) and time spent sedentary (<1.5 metabolic equivalent of tasks), in light PA (1.5-3 metabolic equivalent of tasks) and moderate-to-vigorous intensity PA (>3 metabolic equivalent of tasks). Linear regression models were used to relate each PA parameter to inflammatory (C-reactive protein, interleukin-6), endothelial (tissue-plasminogen activator, E-selectin) and adipokine (leptin, adiponectin) markers extracted from fasting blood samples. Greater time in light PA and moderate-to-vigorous intensity PA and less sedentary time were associated with more favorable biomarker levels. For C-reactive protein, interleukin-6, and leptin, these differences were greater among women than men. For example, % differences (95% confidence intervals) in leptin for men and women per SD increases in sedentary time: 7.9 (2.7, 13.0) and 20.6 (15.3, 25.8); light intensity PA : -3.8 (-8.9, 12.7) and -17.7 (-23.1, -12.4), moderate-to-vigorous intensity PA : -12.9 (-17.9, -8.0) and -18.3 (-23.4, -13.1). Fat mass mediated a greater proportion of these associations in women than men. Conclusions Greater light PA and moderate-to-vigorous intensity PA and less sedentary time in early old age were associated with more favorable cardiovascular biomarker profiles. Fat mass partially mediated these associations but more strongly in women than men, which explained sex differences.

Item Type: Article
Additional Information: © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: accelerometers, aging, cardiac biomarkers, heart rate, older adults, physical exercise, sedentary time
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: J Am Heart Assoc
ISSN: 2047-9980
Language: eng
Dates:
DateEvent
21 August 2018Published
8 August 2018Published Online
13 June 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
MC_UU_12019/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12019/4Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G1001143Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12015/3Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 30369324
Go to PubMed abstract
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/110361
Publisher's version: https://doi.org/10.1161/JAHA.117.007459

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