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Decidual cell regulation of trophoblast is altered in pregnancies at risk of pre-eclampsia

James-Allan, LB; Whitley, GS; Leslie, K; Wallace, AE; Cartwright, JE (2018) Decidual cell regulation of trophoblast is altered in pregnancies at risk of pre-eclampsia. J Mol Endocrinol, 60. pp. 239-246. ISSN 1479-6813 https://doi.org/10.1530/JME-17-0243
SGUL Authors: Cartwright, Judith Eleanor Whitley, Guy St John

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Abstract

Successful implantation and placentation are dependent on the interaction between decidual stromal cells (DSC) and extravillous trophoblast (EVT) cells. The extent of trophoblast invasion relies on communication between the placenta and maternal decidua. The cyclical process of decidualisation induces a transformation of endometrial fibroblasts to secretory DSC; these secreted products have many functions including the control of trophoblast invasion. Inadequate trophoblast invasion and remodelling of the uterine vessels (the spiral arteries) are associated with pregnancy disorders such as pre-eclampsia. Uterine artery Doppler resistance index (RI) in the first trimester of pregnancy can be used as a proxy measure of remodelling. DSC were isolated from pregnancies with normal (normal RI) or impaired (high RI) spiral artery remodelling. Following isolation, DSC were re-decidualised using cAMP and MPA and secretion of the decidualisation markers IGFBP-1 and prolactin assessed. We examined the impact of DSC secreted factors on trophoblast cell function, using the EVT cell line SGHPL-4. We demonstrated that DSC exposed to decidual factors were able to re-decidualise in vitro and that the chemoattraction of trophoblasts by DSC is impaired in pregnancies with high RI. This study provides new insights into the role that DSC play in regulating EVT functions during the first trimester of pregnancy. This is the first study to demonstrate that DSC from pregnancies with impaired vascular remodelling in the first trimester secrete factors that inhibit the directional movement of trophoblast cells. This finding may be important in understanding aberrant trophoblast invasion in pregnancies where vascular remodelling is impaired.

Item Type: Article
Additional Information: © 2018 The authors This work is licensed under a Creative Commons Attribution 4.0 Unported License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Endocrinology & Metabolism, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine, 0707 Veterinary Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: J Mol Endocrinol
ISSN: 1479-6813
Language: eng
Dates:
DateEvent
1 April 2018Published
7 February 2018Published Online
7 February 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
091550Wellcome Trusthttp://dx.doi.org/10.13039/100004440
SP4577Action Medical Researchhttp://dx.doi.org/10.13039/501100000317
PubMed ID: 29437882
Go to PubMed abstract
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/109682
Publisher's version: https://doi.org/10.1530/JME-17-0243

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