{"text_format":"2","workbook":"xlsx","n_sheets":26,"sheets":["ST1. Study Design","ST2. Genotyping and QC","ST3. Study Descriptives","ST4. Study Descriptives by SMK","SD 1. BMI All Ancestries","SD 2. WC All Ancestries","SD 3. WHR All Ancestries","SD 4. BMI_EUR Only","SD 5. WC_EUR Only","SD 6. WHR_EUR Only","SD 7A. KnownLoci_BMI","SD 7B. KnownLoci_WCadjBMI","SD 7C. KnownLoci_WHRadjBMI","ST 5. Conditional_App1","ST 6. Conditional_App2","ST 7. Conditional_App3","ST 8. Type I Error Rate","SD 8. Lookups in Previous GWAS","ST 9. VarianceExplained","ST 10. eQTL_Public Databases","ST 11. eQTL_FramHS_SNPadj","ST 12. eQTL_FramHS_SNPjoint","ST 13. GWASCatalog","ST 14. Lookup of Smoking Loci","ST 15. Validation in UKBB","ST 16. Genetic Risk Score"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":8,"comments":1,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"ST1. Study Design","index":0,"n_rows":94,"n_cols":13,"rows_kept":94,"cut":false,"hidden":false,"merged":[[68,5,69,5],[68,6,68,7],[68,8,68,10],[68,11,69,11],[92,0,92,11],[1,0,1,11],[2,0,2,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,2,7],[2,8,2,10],[2,11,3,11],[67,0,67,11],[68,0,68,1],[68,2,69,2],[68,3,69,3],[68,4,69,4]]}
["Supplementary Table 1. Study design, sample size, and data quality control for contributing genome-wide association study and Metabochip cohorts."]
["GWAS DATA"]
["Study",null,"Study design","Ancestry","Region","Total genotyped sample size (N)","Sample QC",null,"Anthropometric assessment method",null,null,"Study References (PMID)"]
["Short name","Full name",{"$nulls":4},"Call rate*","sample exclusion criteria","BMI","WHR","WHR and BMI were assessed at the same time? "]
["AE","Athero-Express Biobank Study","Cohort-study","European","Utrecht, the Netherlands",690,"≥ 97%","1) heterozygosity (Ĥ) ± 3 standard deviations of the mean \n2) ethnic outliers through Principal Component Analysis compared to HapMap 2 (r22) \n3) related individuals and duplicates, π>0.20 \n4) missing body weight and height \n5) gender-discrepancies","Self-reported","NA","NA",15678794]
["AGES"," Age, Gene/Environment Susceptibility-Reykjavik Study","Population based","European","Iceland",3219,">99%","1) missing phenotypes \n2) mismatch previous genotypes","Measured","NA","NA",17351290]
["ARIC","Atherosclerosis Risk in Communities","Population-based","European","USA-North America",9713,">90%","1) first-degree relatives\n2) ancestry outliers\n3) gender mismatch \n4) identity issues \n5) excessive heterozygosity \n6) missing height or weight"," Measured","Measured","Yes",2646917]
["ARIC","Atherosclerosis Risk in Communities","Population-based","African American","USA-North America",3207,">90%","1) first-degree relatives \n2) ancestry outliers \n3) gender mismatch\n4) identity issues\n5) excessive heterozygosity \n6) missing height or weight"," Measured","Measured","Yes",2646917]
["AUSTWIN","Australian Twin-Family Studies","Population-based","European","Australia",2166,0.95,"1) mendelian errors\n2) HWE p < 10-6\n3) sample call rate  96%","Self-reported","NA","NA",21529783]
["BHS","Busselton Health Study","Population-based","European","Australia",1468,0.97,"1) duplicates \n2) sex check \n3) ethnic outliers \n4) relatedness","Measured","Measured","Yes","15486340,                                       19643935 "]
["BioMe (MSSM)","The Charles Bronfman Institute for Personalized Medicine; BioMe Program","EHR-linked clinical care cohort","European American","USA (New York City)",2026,"≥98%","1) sex mismatch\n2) ancestry Outliers \n3) related Individuals (inbreeding coefficient < -0.1 or > 0.3 for common variants (MAF>1%) \n4) inbreeding coefficient < 0.4 or > 0.9 for rare variants (MAF<1%)","Self-reported","NA","NA",25673413]
["BioMe (MSSM)","The Charles Bronfman Institute for Personalized Medicine; BioMe Program","EHR-linked clinical care cohort","African American","USA (New York City)",3495,"≥98%","1) sex mismatch \n2) ancestry Outliers \n3) related Individuals (inbreeding coefficient < -0.1 or > 0.3 for common variants (MAF>1%) \n4) inbreeding coefficient < 0.4 or > 0.9 for rare variants (MAF<1%)","Self-reported","NA","NA",25673413]
["BioMe (MSSM)","The Charles Bronfman Institute for Personalized Medicine; BioMe Program","EHR-linked clinical care cohort","Hispanic / Latinos","USA (New York City)",4711,"≥98%","1) sex mismatch\n2) ancestry Outliers\n3) related Individuals (inbreeding coefficient < -0.1 or > 0.3 for common variants (MAF>1%) \n4) inbreeding coefficient < 0.4 or > 0.9 for rare variants (MAF<1%)","Self-reported","NA","NA",25673413]
["BLSA","Baltimore Longitudinal Study of Aging","Population-based","European","Italy",1230,0.98,"1) Missing Phenotype                                                        2) sex mismatch                                                     3) ethnic outliers","measured","measured","Yes","NA"]
["British 1958 birth cohort (B58C)","British 1958 birth cohort ","Population-based","European","UK",6481,"≥ 97%","1) Contamination\n2) non-European identity \n3) missing height or weight","Measured","Measured","Yes",17255346]
["CHS","The Cardiovascular Health Study","Population-based cohort","European","USA-North America",3271,">95%","1) baseline CHD, CHF, PAD, valvular heart disease, stroke, TIA\n2) lack of available DNA\n3) genotype discordant with known sex or prior genotyping","Measured","Measured","Yes",1669507]
["CLHNS","Cebu Longitudinal Health and Nutrition Survey (Offspring)","Population-based","East Asian (Filipino)","Philippines",1895,"≥97%","1) 1st-degree relatvies\n2) missing phenotypes (age, weight, height, smoking) ","Measured","Measured","Yes",20507864]
["COLAUS","Cohorte Lausannoise","Population-based","European","Switzerland",5435,0.9,"1) PCA outliers","Measured","Measured","Yes","22415877, \n18366642"]
["CROATIA-Korcula","The CROATIA study, Korcula Island cohort","Population-based","European","Croatia",898,">97%","1) duplicates \n2) gender mismatch \n3) identity issues \n4) excess heterozygousity","Measured","Measured","Yes","18952825                                            19798445"]
["CROATIA-Vis","The CROATIA study, Vis Island cohort","Population-based","European","Croatia",924,">97%","1) duplicates \n2) gender mismatch \n3) identity issues \n4) excess heterozygousity","Measured","Measured","Yes","18952825,                                                     19798445"]
["DESIR","Data from an Epidemiological Study on the Insulin Resistance syndrome","Case-control","European","France",731,"≥90%","1) low call rate (none)\n2) ethnic outliers (n=15 dropped using STRUCTURE)","Measured","Measured","Yes",8927780]
["EGCUT ","Estonian Genome Center, University of Tartu","Population-based","European","Estonia",2059,"≥98%","1) call-rate < 95%\n2) related smaller than 2nd degree\n3) duplicated samples\n4) gender mismatch","Measured","Measured","Yes",24518929]
["EPIC-Norfolk","EPIC (European Prospective Investigation into Cancer) Norfolk ","Population-based","European","England",2417,"≥94%","1) relatedness \n2) ethnic outlier \n3) missing height","Measured","Measured","Yes",10466767]
["ERF","Erasmus Rucphen Family Study","Family-based","European","Netherlands",3485,0.95,"1) gender mismatch \n2) ethnic outliers \n3) sex mismatch \n4) excess heterozygosity \n5) duplicates","Measured","Measured","Yes",15845033]
["FamHS","Family Heart Study","Family-based","European","USA - North America",3869,0.98,"1) To assess Mendelian errors, we ran LOKI on our family data and removed 5,035 SNPs with enough Mendelian errors to be considered outlier SNPs. We also removed 2 individuals who had an unacceptable number (greater than 600) of Mendelian errors, making them outliers as compared to the rest of the population","Measured","Measured","Yes",8651220]
["Fenland","Fenland Study","Population-based","European","UK",1500,0.95,"1) sex-check \n2) relatedness check \n3) ethnic ancestry outlying \n4) hetezygosity check ","Measured","Measured","Yes",20519560]
["FramHS","Framingham Heart Study","Population-based","European","USA",8481,">97%","1) Heterozygosity ± 5 SD from the mean\n2) Call rate < 97%\n3) Excessive Mendelian errors","Measured","Measured","Yes","14025561                                         1208363                                                                    17372189"]
["FUSION","Finland-United States Investigation of NIDDM Genetics","Case-control","European","Finland",2333,">99%","1) Missing phenotypes or age<18\n2) Gender discrepancy or anomaly\n3) Unexplained duplicate sample\n4) Relateds","Measured","Measured","Yes",17463248]
["Gendian","Genetics of Diabetic Nephropathy","Cohort study of type 2 diabetes complications","European","Germany",1026,0.95,"1) call-rate < 95%\n2) related smaller than 2nd degree\n3) duplicated samples\n4) gender mismatch\n5) non-european ethnicity","Measured","Measured","Yes","16961167\n21980298"]
["GS","Generation Scotland","Population-based","European","Scotland",9860,">97%","1) duplicates\n2) gender mismatch \n3) identity issues\n4) excess heterozygousity","Measured","Measured","Yes",22786799]
["GENOA","Genetic Epidemiology Network of Arteriopathy","Cohort of sibships enriched for hypertension","European-American","USA- Rochester, MN",1509,"≥ 95%","1) Identical twins\n2) sex mismatch\n3) outliers (±6 SDs) on first 10 PCs from EIGENSTRAT","Measured","Measured","Yes","11799070, 15121494"]
["GOOD","Gothenburg Osteoporosis and Obesity Determinants Study","Population-based","European","Sweden",941,">97%","1) heterozygosity > 33% \n2) ethnic outliers\n3) related individuals \n4) duplicates","Measured","Measured","Yes",22247082]
["GOYA cases","Genetics of Overweight Young Adults","Population-based (case-cohort)","European","Denmark","671 cases,",0.95,"1) heterozygosity \n2) duplicates\n3) sex mismatch \n4) non-caucasians","Measured","Measured","Yes"," 18445669, 21935397"]
["GOYA controls","Genetics of Overweight Young Adults","Population-based (case-cohort)","European","Denmark","790 controls",0.95,"1) heterozygosity \n2) duplicates\n3) sex mismatch \n4) non-caucasians ","Measured","Measured","Yes"," 18445669, 21935397"]
["HERITAGE Family Study","Health, Risk Factors, Training \nand Genetics (HERITAGE) Family Study","Baseline measurements of an exercise intervention","European","USA -North America",499,">99%","None","Measured","Measured","Yes",21183627]
["HRS","Health and Retirement Study","Population-based","European-American","USA-North America",8652,">98%","1) duplicates \n2) gender discrepancy \n3) relatedness \n4) ethnic outliers","Measured","NA","NA",24671021]
["HRS","Health and Retirement Study","Population-based","African American","USA-North America",1519,">98%","1) duplicates \n2) gender discrepancy \n3) relatedness\n4) ethnic outliers","Measured","NA","NA",24671021]
["HYPERGENES","HYPERGENES","Case-Control","European","Europe",3916,">95%","1) first-degree and second-degree relatives \n2) ancestry outliers \n3) gender mismatch \n4) identity issues \n5) excessive heterozygosity \n6) missing height or weight","Measured","Measured","Yes",22184326]
["InCHIANTI","Invecchiare in Chianti","Population-based","European","Italy",1231,0.97,"1) missing Phenotype                      2) sex mismatch                               3) Heterozygosity > 0.3","Measured","Measured","Yes",11129752]
["KORA3","Cooperative Health Research in the Region of Augsburg","Population-based","European","Germany",1644,0.93,"1) german passport\n2) missing height","Measured","Measured","Yes","16032513, 16032514"]
["KORA4","Cooperative Health Research in the Region of Augsburg","Population-based","European","Germany",1814,0.93,"1) german passport\n2) missing height","Measured","Measured","Yes","16032513, 16032514"]
["Lifelines","Lifelines Cohort study","Population-based","European","The Netherlands",9388,0.95,"1) heterozygosity > 4SD from mean \n2) duplicate and MZ samples \n3) first-degree relatives \n4) sex mismatch \n5) non-caucasians","Measured","Measured","Yes","18075776, 25502107, 26333164"]
["LOLIPOP_EW610","London Life Sciences Prospective Population Study","Population-based","European","UK - Lodon",945,0.95,"1) duplicates \n2) gender discrepancy\n3) contaminated samples \n4) relatedness","Measured","Measured","Yes",21909110]
["LOLIPOP_IA317","London Life Sciences Prospective Population Study","Population-based with some enrichment","Indian Asian","UK - Lodon",2694,0.95,"1) duplicates\n2) gender discrepancy\n3) ethnic outliers \n4) contaminated samples \n5) relatedness\n6) samples already in IA610","Measured","Measured","Yes",18454146]
["LOLIPOP_IA610","London Life Sciences Prospective Population Study","CHD case-control study","Indian Asian","UK - Lodon",7032,0.95,"1) duplicates \n2) gender discrepancy \n3) ethnic outliers \n4) contaminated samples \n5) relatedness","Measured","Measured","Yes",19820698]
["LURIC","Ludwigshafen Risk and Cardiovascular Health Study","Case-control","European","Ludwigshafen, Germany",2984,"≥95%","1) related individuals\n2) ambigous sex","Measured","Measured","Yes",11258203]
["MESA","Multi-Ethnic Study of Atherosclerosis","Population-based","European","USA-North America",2399,">95%","1) first-degree relatives\n2) ancestry outliers \n3) gender mismatch, \n4) excessive heterozygosity \n5) missing height or weight","Measured","Measured","Yes",19075250]
["MrOS Sweden","Osteoporotic Fractures in Men (MrOS) Sweden","Population-based","European","Sweden",962,">97%","1) exclusion based on IBD clustering\n2) checked for duplicates \n3) identical twins","Measured","NA","NA",16598372]
["NTR","Netherlands Twin Register","Population-based","European","Netherlands",3331,">90%","1) duplicates\n2) gender discrepancy\n3) contaminated samples\n4) relatedness","Measured","Measured","Yes","18763692, 18197199"]
["NFBC66 ","Northern Finland Birth Cohorts 1966 ","Population-based","European","Finland",5402,"≥95%","(1) duplicates                                               (2) contaminated samples                          (3) excess heterozygosity                             (4) cryptic relatedness                          (5) withdrew consent                      (6) gender mismatch                               (7)  MDS outliers","Measured","Measured","Yes",4911003]
["NHS","The Nurses' Health Study","Population-based","European","USA",2368,0.95,"1) duplicate\n2) samples with misidentified sex, \n3) related samples (siblings or possible first cousins)\n4) samples with evidence of contamination\n5) samples with highly variable intensity data, and \n6) samples with missing call rates >=2% were excluded. ","Measured","Measured","Yes",7860180]
["ORCADES","Orkney Complex Disease Study","Population-based","European","Scotland",889,">97%","1) duplicates\n2) gender mismatch\n3) identity issues\n4) excess heterozygousity","Measured","Measured","Yes",18760389]
["PIVUS","The Prospective Investigation of the Vasculature in Uppsala Seniors ","Prospective cohort","European","Sweden",949,">95%","1) gender mismatch                                2) excess heterozygosity                    3) duplicates","Measured","Measured","Yes",16141402]
["Prevend","Prevention of renal and vascular end-stage disease","Population-based","European","The Netherlands",3649,"≥95%","1) ethnic outliers\n2) related individuals and duplicates\n3) missing phenotype","Measured","Measured","Yes",12356629]
["PROSPER","The PROspective study of Pravastatin in the Elderly at Risk for vascular disease","Population-based","European","Europe",5244,"≥95%","1) sex mismatch\n2) ethnic outliers\n3) heterozygosity (3 SD)","Measured","NA","NA",10569329]
["QFS","Quebec Family Study","Population-based","European","Quebec-Canada",929,0.95,"None","Measured","Measured","Yes",24533236]
["Rotterdam Study I","Rotterdam Study - I","Population-based","European","Netherlands",5974,"≥ 98%","1) sex mismatch                                                       2)excess autosomal heterozygosity >0.336 3) outliers identified by IBS clustering analysis","Measured","Measured","Yes",26386597]
["Rotterdam Study II","Rotterdam Study - II","Population-based","European","Netherlands",2157,"≥98%","1) sex mismatch                                             2)excess autosomal heterozygosity >0.336                                                               3) outliers identified by IBS clustering analysis","Measured","Measured","Yes",26386597]
["Rotterdam Study III","Rotterdam Study - III","Population-based","European","Netherlands",2078,"≥ 98%","1) sex mismatch                                                                           2)excess autosomal heterozygosity >0.336                                                             3) outliers identified by IBS clustering analysis","Measured","Measured","Yes",26386597]
["SardiNIA","SardiNIA Study on Aging","Population-based","European","Ogliastra Region in Sardinia (Italy)",4694,0.95,"1) gender discrepancy with genetic data from X‐linked marker; 2) discrepancy between genetically inferred relationship with other samples and reported pedigree information","Measured","Measured","Yes","16934002, 22291609"]
["SHIP","Study of Health in Pomerania","Population-based","European","Germany - West Pomerania",4081,">92%","1) duplicates\n2) gender discrepancy","Measured","Measured","Yes",20167617]
["THISEAS","The Hellenic study of Interactions between Snps and Eating in Atherosclerosis Susceptibility","CAD case-control","European","Greece",1000,"≥95%","1) sex mismatch\n2) ethnic outliers\n3) heterozygosity (3 SD)","Measured","Measured","Yes",20167083]
["TRAILS","Tracking Adolescents' Individual Lives Survey","Population-based","European","The Netherlands",1354,0.95,"1) heterozygosity\n2) duplicate and MZ samples \n3) sex mismatch \n4) non-caucasians ","Measured","Measured","Yes","18263649, 23021478, 25431468"]
["TwinsUK","TwinsUK","Population-based","European","UK",5654,">98%","1) call-rate < 98%\n2) heterozygosity across all SNPs ≥2 s.d. from the sample mean\n3) duplicated samples\n4) gender mismatch\n5) evidence of non‐European ancestry as assessed by PCA comparison with HapMap3 population\n6) observed pairwise IBD probabilities suggestive of sample identity errors","Measured","Measured","Yes",23088889]
["WGHS","Women's Genome Health Study","Population-based","European","USA ",23294,0.98,"None","Self-reported","Self-reported","No, waist and WHR assessed 6 years after BMI",18070814]
["YFS","The Cardiovascular Risk in Young Finns Study","Population-based","European","Finland",2442,0.95,"1) gender mismatch\n2) excess heterozygosity\n3) duplicates \n4) cryptic relatedness \n5) ethnic outliers","Measured","Measured","Yes",18263651]
[]
["METABOCHIP DATA"]
["Study",null,"Study design","Ancestry","Region","Total sample size (N)","Sample QC",null,"Anthropometric assessment method",null,null,"Study References (PMID)"]
["Short name","Full name",{"$nulls":4},"Call rate*","sample exclusion criteria","BMI","WHR","WHR and BMI were assessed at the same time? "]
["DESIR","Data from an Epidemiological Study on the Insulin Resistance syndrome","Population based","European","France",4993,"≥ 90%","1) missing data\n2) ethnic outliers (n=66 dropped using PCA)","Measured","Measured","Yes",8927780]
["DR's EXTRA","DR's EXTRA","Population-based","European","Finland",1250,">99%","1) missing phenotypes or age<18\n2) gender discrepancy or anomaly\n3) unexplained duplicate sample\n4) relateds across DR's EXTRA, FUSION, and METSIM","Measured","Measured","Yes",8177243]
["EGCUT Metabochip","Estonian Genome Center, University of Tartu","Population-based","European","Estonia",2510,"≥ 98%","1) call-rate < 95%\n2) related smaller than 2nd degree\n3) duplicated samples\n4) gender mismatch","Measured","Measured","Yes",24518929]
["Ely","MRC Ely Study","Population-based","European","UK",1602,0.95,"1) sex-check\n2) relatedness check \n3) ethnic ancestry outlying \n4) hetezygosity check ","Measured","Measured","Yes",17257284]
["EPIC","European Prospective Investigation into Cancer and Nutrition - Obesity Study","Case-cohort design","European","UK",1700,0.95,"1) sex-check\n2) relatedness check \n3) ethnic ancestry outlying \n4) hetezygosity check ","Measured","Measured","Yes","10466767                          12795830"]
["Fenland","Fenland Study","Population-based","European","UK",3217,0.95,"1) sex-check \n2) relatedness check \n3) ethnic ancestry outlying \n4) hetezygosity check ","Measured","Measured","Yes",20519560]
["FUSION2","Finland-United States Investigation of NIDDM Genetics","Case-control","European","Finland",2014,">99%","1) missing phenotypes or age<18\n2) gender discrepancy or anomaly\n3) unexplained duplicate sample\n4) relateds across DR's EXTRA, FUSION, and METSIM","Measured","Measured","Yes",17463248]
["GLACIER","Gene x Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk","Population-based","European","Sweden",6064,"≥95%","1) call-rate < 95%\n2) sex mismatch","Measured","Waist, but not hip circumference ","Yes",25396097," "]
["GXE","Gene By Environment","Population-based","Jamaican","Caribbean",613,"≥95%","1) missing phenotype data                                              2) heterozygosity                                         3) PCA outliers                                    4) IBD cryptic relateds","Measured","Measured","Yes","9103091,  9098179,  20400458"]
["Health2006","Health2006","Population-based","European","Capital region of Denmark",3207,">99%","1) individuals with 1st or 2nd degree familial relationship \n2) extreme inbreeding coefficient \n3) low call rate\n4) mislabelled sex and \n5) high discordance to previous genotypings","Measured","Measured","Yes",23615486]
["HUNT","The Nord-Trøndelag Health Study","Population-based with enrichment for T2D cases","European","Norway",1567,">99%","1) missing phenotypes or age<18\n2) gender discrepancy or anomaly\n3) unexplained duplicate sample\n4) relateds","Measured","Measured","Yes","[No PMID]\nHolmen J, Midthjell K, et al. The Nord-Trøndelag Health Study 1995-97 (HUNT 2):Objectives, contents, methods and participation. Nor J Epidemiol 2003;13(1):19-32.                                                          "]
["IMPROVE","Carotid Intima Media Thickness (IMT) and IMT-PRogression as Predictors of Vascular Events in a High-Risk European Population","Population-based (high CVD-risk)","European","Europe (Italy, France, Netherlands, Sweden, Finland)",3426,"≥ 95%","1) ambiguous sex\n2) cryptic relatedness \n3) non-european descent","Measured","Measured","Yes",22999719]
["Inter99 (I99)","Inter99","Population-based","European","Capital region of Denmark",6127,">99%","1) individuals with 1st or 2nd degree familial relationship\n2) extreme inbreeding coefficient \n3) low call rate\n4) mislabelled sex and \n5) high discordance to previous genotypings","Measured","Measured","Yes","14663300\n12882858\n19898830"]
["KORA S3","Cooperative Health Research in the Region of Augsburg","Population-based","European","Germany",3113,0.93,"none","Measured","Measured","Yes","16032513 16032514"]
["KORA S4","Cooperative Health Research in the Region of Augsburg","Population-based","European","Germany",3028,0.93,"none","Measured","Measured","Yes"]
["MEC","The Multiethnic Cohort Study","Population-based","African","USA-North America","≥ 95%",">95%","1) first-degree relatives \n2) ancestry outliers \n3) gender mismatch \n4) identity issues \n5) excessive heterozygosity \n6) missing height or weight","Self-reported"," Self-measured","Yes",10695593]
["METSIM","Metabolic Syndrome In Men","Population-based with enrichment for T2D cases","European","Finland",2162,">99%","1) missing phenotypes or age<18\n 2) gender discrepancy or anomaly\n 3) unexplained duplicate sample\n 4) relateds across DR's EXTRA, FUSION, and METSIM","Measured","Measured","Yes",19223598]
["NSHD","MRC National Survey of Health & Development ","Birth cohort","European","UK",2476,0.95,"1) sex-check\n2) relatedness check \n3) ethnic ancestry outlying \n4) hetezygosity check ","Measured","Measured","Yes","15814867 \n16204333"]
["SCARFSHEEP","Stockholm Coronary Atherosclerosis Risk Factor-Stockholm Heart Epidemiology Program ","MI case-control","European","Europe (Stockholm, Sweden)",2899,"≥95%","1) ambiguous sex \n2) cryptic relatedness \n3) non-european descent","Measured","Measured","Yes","16238676                                         10447785"]
["SPT","Spanish Town","Population-based","Jamaican","Caribbean",476,"≥95%","1) missing phenotype data                       2) heterozygosity                                        3) PCA outliers                                        4) IBD cryptic relateds","Measured","Measured","Yes","9103091,  9098179,  20400458"]
["WHI","Women's Health Initiative Study","Population-based","African","USA-North America","YR3/YR4 (3508) ; Pilot (2203) ",">95%","1) first-degree relatives\n2) ancestry outliers\n3) gender mismatch \n4) identity issues \n5) excessive heterozygosity\n6) missing height or weight","Measured","Measured","Yes",14575938]
["Whitehall","The Whitehall II study","Cohort of London-based civil servants","European","UK",2413,0.95,"1) missing phenotype data\n2) gender check\n3) duplicates check\n4) relatedness check\n5) ethnic check","Measured","Measured","Yes","15576467 \n21441441"]
["VALIDATION DATA"]
["UKBB","UK Biobank","Population study","White British","UK",120286,"NA, See UKB document on QC http://biobank.ctsu.ox.ac.uk/showcase/refer.cgi?id=155580 ","1) Sex mismatch\n2) HWE P<1x10-6\n3) non British ancestry","Measured","Measured","Yes","DOI: 10.1371/journal.pmed.1001779"]

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["Supplementary Table 2. Information on genotyping methods, quality control of SNPs, imputation, and statistical analysis for GWAS and Metabochip study cohorts. Abbreviations: MAF- minor allele frequency, HWE- Hardy-Weinberg Equilibrium, QC- quality control, SNP- single nucleotide polymorphism, GWAS- genome-wide association study."]
["GWAS DATA"]
["Study","Ancestry","Genotyping",{"$nulls":4},"Imputation",null,null,null,"Statistical Analysis Software"]
[null,null,"Genotyping array","Genotype calling software","SNP QC",null,"No. of SNPs after QC","No. of SNPs used for imputation","Imputation Sofware","Imputation reference panel (NCBI build)","Imputed X chromosome data available? (software, reference)"]
[{"$nulls":4},"Call rate*","p for HWE"]
["AE","European","Affymetrix SNP 5.0","BRLMM-P","≥ 97%","> 10-6",403789,403789,"BEAGLE v3.3.2","HapMap r 22 CEU","No","PLINKv1.07"]
["AGES","European","Illumina Hu370CNV","BeadStudio",">97%","> 10-6",325094,308340,"Mach + MiniMac","HapMap r 22 CEU","Yes, (IMPUTE2)","ProbABEL"]
["ARIC","European","Affymetrix 6.0","Birdseed","≥ 90%","> 10-6",685812,685812,"MACH v1.0.16","HapMap CEU, release 22, build 36","No","ProbABEL"]
["ARIC","African American","Affymetrix 6.0","Birdseed","≥ 90%","> 10-6",685812,685812,"MACH v1.0.16","HapMap YRI, release 22, build 36","No","ProbABEL"]
["AUSTWIN","European","Illumina370, Illumina610","Beadstudio-gencall v3.0",0.95,"> 10-6",269840,269840,"MACH v1.0.15","HapMap r22 (build 36)","No","ProbABEL,R"]
["BHS","European","Illumina 610 Quad","BeadStudio",">95%","> 10-6",529526,529526,"MaCH","HapMap r 22 CEU","No","ProbABEL, mach2qtl"]
["BioMe (MSSM)","European American","Illumina HumanOmniExpressExome-8 v1.0","zCall (GenomeStudio)","≥ 90%","> 10-6",906917,768517,"IMPUTE2","I000G v3 (March 2012)","Yes","SAS, Quicktest"]
["BioMe (MSSM)","African American","Illumina HumanOmniExpressExome-8 v1.0","zCall (GenomeStudio)","≥ 90%","> 10-6",906917,768517,"IMPUTE2","I000G v3 (March 2012)","Yes","SAS, Quicktest"]
["BioMe (MSSM)","Hispanic / Latinos","Illumina HumanOmniExpressExome-8 v1.0","zCall (GenomeStudio)","≥ 90%","> 10-6",906917,768517,"IMPUTE2","I000G v3 (March 2012)","Yes","SAS, Quicktest"]
["BLSA","European","Illumina 450K","BeadStudio","≥ 99%","> 10-6",514027,514027,"MACH","HapMap release22, build 36","No","ProbABEL"]
["British 1958 birth cohort (B58C)","European","Illumina 550k_v1, 550k_v3, 610k (3 non-overlapping subsets)","BeadStudio","≥ 95%","> 10-4",500521,500521,"MACH/Minimac","HapMap r 21 CEU","Yes, (MACH/Minimac)","ProbABEL"]
["CHS","European","Illumina 370CNV BeadChip","Illumina BeadStudio","≥ 97%","> 10-5",306655,306655,"BIMBAM v0.99","HapMap release22, build 36","Yes, (build 36, release 24)","R"]
["CLHNS","East Asian (Filipino)","Affymetrix Genome-Wide Human SNP Array 5.0","Birdseed (version 2)","≥ 90%","> 10-6",352264,352264,"MACH v.1.0","HapMap r22 CHB+JPT+CEU","No","ProbABEL, mach2qtl"]
["COLAUS","European","Affymetrix 500k","APT",0.9,"> 10-7",390631,390631,"IMPUTE","HapMap r 21 CEU","No","Matlab"]
["CROATIA-Korcula","European","Illumina HumanHap370 CNV","BeadStudio",">98%","> 10-6",316730,316730,"MACH","HapMap r 22 CEU","No","ProbABEL"]
["CROATIA-Vis","European","Illumina HumanHap300","BeadStudio",">98%","> 10-6",308996,308996,"MACH","HapMap r 22 CEU","No","ProbABEL"]
["DESIR","European","Illumina Human CNV370-Duo Array and Illumina HAP300 array","BeadStudio","≥ 95%","> 10-4","291 609","291 609","IMPUTE2","HapMap r 22 CEU","No","SNPtest"]
["EGCUT GWAS","European","Illumina OmniExpress","Illumina BeadStudio",0.95,"> 10-6",611549,611549,"IMPUTE2","HapMap r 22 CEU","No","R, Quicktest"]
["EPIC-Norfolk","European","Affymetrix 500K","BRLMM","≥ 90%","> 10-6",382036,382036,"IMPUTE","HapMAP 21 CEU","Yes","Quicktest"]
["ERF","European","Illumina 318K, 370K, 610K, Affymetrix 250K","Genome Studio & Beadstudio, BRLMM",0.95,"> 10-6",649956,635956,"MACH 1.0.16","HapMap release22, build 36","Yes, (build 36, rel 22 (IMPUTE))","GenABEL, ProbABEL"]
["FamHS","European","Illumina HumMap 550k, Human610-Quadv1, Human 1M-Duov3","BeadStudio",0.98,"> 10-6",2543887,499558,"MaCH","HapMap r 22 CEU","Yes","SAS, R"]
["Fenland","European","Affymetrix SNP5.0","BRLMM",0.95,"> 10-6",360602,360602,"IMPUTE2","1000GP Phase1 v3","Yes","SNPtest, Quicktest"]
["FramHS","European","Affymetrix 500K                                           Affymetrix 50K supplemental","BRLMM",">97%","> 10-6",378163,378163,"MACH v1.0.15","HapMap r 22 CEU","Yes","R"]
["FUSION","European","Illumina HumanHap300","BeadStudio",">98%","> 10-6",315635,315635,"MaCH","HapMap r 22 CEU","No","ProbABEL"]
["Gendian","European","Genome-Wide Human SNP Array 6.0 ","Affymetrix - birdseed, (algorithm: BRLMM)","MAF>.1 & callrate<.9\nMAF>.09 & MAF  ≤.1 & callrate <.91\nMAF>.08 & MAF  ≤.09 & callrate<.92\nMAF>.07 & MAF  ≤.08 & callrate<.93\nMAF>.06 & MAF  ≤.07 & callrate<.94\nMAF>.05 & MAF  ≤.06 & callrate<.95\nMAF>.04 & MAF  ≤.05 & callrate<.96\nMAF>.03 & MAF  ≤.04 & callrate<.97\nMAF>.02 & MAF  ≤.03 & callrate<.98\nMAF>.01 & MAF  ≤.02 & callrate<.99  \nMAF ≤.01 & callrate <.99 ","> 10-6",747402,747402,"Mach 1.0.18.c\nMiniMac 2012-10-09","GIANT ALL 1000G v3 ref panel GRCh build 37","Yes, (MaCH/ minimac, GIANT ALL 1000G v3 ref panel GRCh build 37)","ProbAbel, R, Plink"]
["Generation Scotland","European","Illumina HumanOmniPlusExome","BeadStudio",">98%","> 10-6",706980,706980,"ShapeIt2 + IMPUTE2","1000G (ALL)","Yes, (IMPUTE2)","ProbABEL"]
["GENOA","European American","Affymetrix 6.0 & Illumina 1M-Duo Bead Chip","Birdseed and Genome Studio","≥ 95%","NA","Affymetrix: 596,941; Illumina: 804,154","Affymetrix: 596,941; Illumina: 804,154","MACH 1.0.16","HapMap (release 22) CEU","No","MMAP"]
["GOOD","European","Illumina 610","Beadstudio",">98%","> 10-6",553191,521160,"MaCH","HapMap CEU, release 22, build 36","Yes","PLINK, R"]
["GOYA cases","European","Illumina 610K Quad","GenomeStudio","≥ 95%","> 10-7",545349,545349,"Mach 1.0","HapMap r22 (build 36)","No","Quicktest"]
["GOYA controls","European","Illumina 610K Quad","GenomeStudio","≥ 95%","> 10-7",545349,545349,"Mach 1.0","HapMap r22 (build 36)","No","Quicktest"]
["HERITAGE Family Study","European","Illumina 370CNV","GenomeStudio","≥ 98%","> 10-6",324607,324607,"MaCH","HapMap r 22 CEU","No","ProbABEL"]
["HRS","European American","Illumina Omni2.5 Beadchip","BeadStudio",0.98,"> 10-4",1681327,551936,"MaCH","HapMap r 22 CEU","Yes, (MaCH)","PLINK, ProbABEL"]
["HRS","African American","Illumina Omni2.5 Beadchip","BeadStudio",0.98,"> 10-4",1681327,909595,"MaCH","HapMap r 22 CEU+YRI","No","PLINK, ProbABEL"]
["HYPERGENES","European","Illumina 1M-Duo","Genome-Studio","≥ 99%","> 10-8",882854,882854,"Minimac","HapMap r 22 CEU","No","PLINK"]
["InCHIANTI","European","Illumina 450K","BeadStudio","≥ 99%"," 10-4",498838,498838,"MACH","HapMap release22, build 36","No","ProbABEL"]
["KORA3","European","Affymetrix 500K","BRLMM","none","none","No",490032,"MACH v1.0.9","HapMap r 22 CEU","No","ProbABEL, R"]
["KORA4","European","Affymetrix 6.0","Birdseed","none","none",909622,909622,"IMPUTE v0.4.2","HapMap r 22 CEU","No","ProbABEL, R"]
["Lifelines","European","Illumina Cyto SNP12 v2","GenomeStudio",">95%","> 10-4",257581,257581,"BEAGLE v3.3.2","HapMap r24 CEU (build 36)","No","PLINKv1.07"]
["LOLIPOP_EW610","European","Illumina Human610","BeadStudio",0.95,"> 10-6",544620,544620,"IMPUTE2","HapMap r 22 CEU","No","Quicktest"]
["LOLIPOP_IA317","Indian Asian","Illumina HumanHap300","BeadStudio",0.95,"> 10-6",307303,307303,"IMPUTE2","HapMap r 22 population combined","No","Quicktest"]
["LOLIPOP_IA610","Indian Asian","Illumina Human610","BeadStudio",0.95,"> 10-6",544390,544390,"IMPUTE2","HapMap r 22 population combined","No","Quicktest"]
["LURIC","European","Affymetrix 6.0","Birdseed v2","≥ 98%","> 10-4",686195,686195,"MaCH","HapMap r 22 CEU","No","ProbABEL"]
["MESA","European","Affymetrix 6.0","Birdseed v2",">95%","NA",854755,854755,"IMPUTE v2.1.0","HapMap r24 CEU","No","ProbABEL"]
["MrOS Sweden","European","Illumina 1M","Beadstudio",0.97,"> 10-4",739477,714543,"Minimac","HapMap CEU, release 22, build 36","No","PLINK, R"]
["Netherlands Twin Register","European","Affymetrix 6.0 + affymetrix perlegen 5.0 + Illumina 370 + Illumina 660 + Illumina Omni Express 1 M","Beadstudio",">95%","> 10-6","311,567-932,824","311567-932824","IMPUTE 2","Hapmap 2 build 36 release 24 CEU reference set","No","Quicktest"]
["NFBC66 ","European","Illumina HumanCNV370DUO Analysis BeadChip","Beadstudio","  ≥ 95%, MAF< 5%, call rate ≥ 99%","≥ 10-7",324896,324896,"IMPUTE2","HapMap r 22 CEU","No","SNPTEST2, Quicktest"]
["NHS","European","Affymetrix 6.0","BeadStudio",0.95,"> 10-6",704409,704409,"MaCH","HapMap r 22 CEU","No","ProbABEL, R"]
["ORCADES","European","Illumina HumanHap300","BeadStudio",">98%","> 10-6",293687,293687,"MACH","HapMap r 22 CEU","No","ProbABEL"]
["PIVUS","European","Human Omni Express and Metabochip","GenCall",0.95,">10-6",738879,738879,"IMPUTE2","HapMap r 22 CEU","NA","SNPTEST, Quicktest"]
["Prevend","Euopean","Illumina Cyto SNP12 v2","GenomeStudio",">95%","> 10-4",232571,232571,"BEAGLE v3.3.2","phased CEU haplotypes, HapMap release 22 (build 36)","No","PLINK, ProbABEL"]
["PROSPER","European","Illumina 660K Quad","Beadstudio","≥ 98%","> 10-6",557192,557192,"MACH 1.0.15","HapMap r 22 CEU","No","PROBABEL"]
["QFS","European","Illumina 610-Quad chip","BeadStudio",0.95,"> 10-4",543713,525406,"MACH","HapMap r 22 CEU","No","GWAF 2.0, R"]
["Rotterdam Study I","European","Version 3 Illumina Infinium II, HumanHap 550 SNP chip array","BeadStudio",">98 %","> 10-6",512349,512349,"MACH","HapMap release22, build 36","No","SPSS, ProbABEL, R"]
["Rotterdam Study II","European","Version 3 Illumina Infinium II, HumanHap 550 SNP chip array","BeadStudio",">98 %","> 10-6",466389,466389,"MACH","HapMap release22, build 36","No","SPSS, ProbABEL, R"]
["Rotterdam Study III","European","Version 3 Illumina Infinium II, HumanHap 550 SNP chip array","BeadStudio",">98 %","> 10-6",514073,514073,"MACH","HapMap release22, build 36","No","SPSS, ProbABEL, R"]
["SardiNIA","European","Affymetrix 10K, 500K, 6.0","BRLMM, Birdseed",0.95,"≥ 10-6",759213,731209,"MACH","HapMap r 22 CEU","No","ProbABEL, R"]
["SHIP","European","Affymetrix 6.0","Birdseed2",">92%","NA",869224,869224,"IMPUTE v0.5.0","Hapmap r22 CEU","No","Quicktest"]
["THISEAS","European","Illumina OmniExpress","Illuminus","≥98%","> 10-6",733202,"NA","NA","NA","No","Plink, Quicktest"]
["TRAILS","European","Illumina Cyto SNP12 v2","GenomeStudio",0.95,"> 10-4",260127,260127,"IMPUTE2","HapMap r 22 CEU","Yes","Quicktest"]
["TwinsUK","European","Illumina 318K, 610K","Illluminus","MAF≥.05 & callrate <.97\nMAF≥.01 & MAF <.05 & callrate<.99\n","> 10-6","Illumina 318K: 303,940, 610K: 553,487","Illumina 318K: 303,940, 610K: 553,487","IMPUTE2","HapMap r 22 CEU","No","Quicktest"]
["WGHS","European","Illumina Human Hap Duo 300 +","BeadStudio",0.98,"> 10-6",339596,333470,"MaCH","HapMap r 22 CEU","Yes","ProbABEL, R"]
["YFS","European","Illumina 670k custom","Illuminus",0.95,"> 10-6",546674,534047,"MACH 1.0","HapMap release22, build 36","No","ProbABEL"]
[]
["METABOCHIP DATA"]
["Study","Ancestry","Genotyping",{"$nulls":4},"Imputation",null,null,null,"Statistical Analysis Software"]
[null,null,"Genotyping array","Genotype calling software","SNP QC",null,"No. of SNPs after QC","No. of SNPs used for imputation","Imputation Sofware","Imputation reference panel (NCBI build)","Imputed X chromosome data available? (software, reference)"]
[{"$nulls":4},"Call rate*","p for HWE"]
["DESIR","European","Illumina Metabochip","BeadStudio","≥ 95%","> 10-4",194763,"NA","NA","NA","No","PLINK, SNPtest, Quicktest"]
["DR's EXTRA","European","Illumina Metabochip","BeadStudio",">98%","> 10-6",188072,"NA","NA","NA","No","Quicktest"]
["EGCUT Metabochip","European","Illumina Metabochip"," BeadStudio",0.95,"> 10-6",138179,"No","No","No","No","R, Quicktest"]
["Ely","European","Illumina Metabochip","GeneCall",0.95,"> 10-6",144581,"NA","NA","NA","No","PLINK, Quicktest"]
["EPIC-Norfolk","European","Illumina Metabochip","GeneCall",0.95,"> 10-6",140943,"NA","NA","NA","No","PLINK, Quicktest"]
["Fenland","European","Illumina Metabochip","GeneCall",0.95,"> 10-6",149819,"NA","NA","NA","No","PLINK, Quicktest"]
["FUSION2","European","Illumina Metabochip","BeadStudio",">98%","> 10-6",188072,"NA","NA","NA","No","Quicktest"]
["GLACIER","European","Illumina Metabochip","Illuminus","≥ 95%","> 10-5",149782,"NA","NA","NA","No","SAS, Quicktest"]
["GXE","Jamaican","Illumina Metabochip","Birdseed","≥ 90%","> 10-6",195531,"NA","NA","NA","NA","R, PLINK"]
["Health2006","European","Illumina Metabochip","GenomeStudio","none","none",196725,"NA","NA","NA","No","PLINK"]
["HUNT","European","Illumina Metabochip","BeadStudio",">98%","> 10-6",188573,"NA","NA","NA","No","Quicktest"]
["IMPROVE","European","Metabochip","GeneCall","≥ 95%","> 10-6",185704,"NA","NA","NA","No","PLINK"]
["Inter99 (I99)","European","Illumina Metabochip","GenomeStudio","none","none",196725,"NA","NA","NA","No","PLINK"]
["KORA S3","European","Illumina Metabochip","Genome Studio","none","none",185781,"NA","NA","NA","No","ProbABEL, R"]
["KORA S4","European","Illumina Metabochip","Genome Studio","none","none",185781,"NA","NA","NA","No","ProbABEL, R"]
["MEC","African","Illumina Metabochip","GenomeStudio with the GenCall 2.0 algorithm","≥ 95%","> 10-6",196725,"NA","NA","NA","No","PLINK"]
["METSIM","European","Illumina Metabochip","BeadStudio",">98%","> 10-6",188072,"NA","NA","NA","No","Quicktest"]
["NSHD","European","Illumina Metabochip","GeneCall",0.95,"> 10-6",147949,"NA","NA","NA","No","PLINK, Quicktest"]
["SCARFSHEEP","European","Metabochip","GeneCall","≥ 95%","> 10-6",185704,"NA","NA","NA","No","PLINK"]
["SPT","Jamaican","Illumina Metabochip","Birdseed","≥ 90%","> 10-6",195567,"NA","NA","NA","NA","R, Plink"]
["WHI","African","Illumina Metabochip","GenomeStudio with the GenCall 2.0 algorithm","≥ 95%","> 10-6",196725,"NA","NA","NA","No","PLINK"]
["WHITEHALL","European","Illumina Metabochip","GeneCall",0.95,"> 10-6",151534,"NA","NA","NA","No","Plink, Quicktest"]
["VALIDATION DATA"]
["UKBB","White British","UK Biobank Axiom Array and UK BiLEVE array","Affymetrix Power Tools","NA","NA","NA","NA","NA","NA","NA","STATA"]

{"sheet":"ST3. Study Descriptives","index":2,"n_rows":221,"n_cols":22,"rows_kept":221,"cut":false,"hidden":false,"merged":[[2,16,3,17],[2,18,2,21],[3,8,3,9],[3,10,3,11],[3,12,3,13],[3,18,3,19],[3,20,3,21],[1,0,1,21],[2,0,4,0],[2,1,4,1],[2,2,4,2],[2,3,4,3],[2,4,3,5],[2,6,3,7],[2,8,2,13],[2,14,3,15],[5,1,7,1],[8,0,10,0],[8,1,10,1],[11,0,13,0],[11,1,13,1],[31,0,32,0],[31,1,32,1],[33,0,34,0],[33,1,34,1],[14,0,16,0],[14,1,16,1],[18,0,19,0],[18,1,19,1],[20,0,22,0],[20,1,22,1],[5,0,7,0],[36,0,37,0],[36,1,37,1],[23,0,25,0],[23,1,25,1],[26,0,28,0],[26,1,28,1],[29,0,30,0],[29,1,30,1],[47,0,48,0],[47,1,48,1],[49,0,50,0],[49,1,50,1],[51,0,52,0],[51,1,52,1],[38,0,40,0],[38,1,40,1],[41,0,43,0],[41,1,43,1],[44,0,46,0],[44,1,46,1],[62,0,64,0],[62,1,64,1],[65,0,66,0],[65,1,68,1],[67,0,68,0],[69,0,71,0],[69,1,71,1],[54,0,55,0],[54,1,55,1],[56,0,58,0],[56,1,58,1],[59,0,61,0],[59,1,61,1],[84,0,85,0],[84,1,85,1],[86,0,87,0],[86,1,87,1],[88,0,89,0],[88,1,91,1],[90,0,91,0],[72,0,74,0],[72,1,74,1],[75,0,77,0],[75,1,77,1],[79,1,80,1],[81,0,83,0],[81,1,83,1],[98,0,99,0],[98,1,99,1],[100,0,101,0],[100,1,101,1],[103,0,104,0],[103,1,106,1],[105,0,106,0],[92,0,93,0],[92,1,93,1],[94,0,95,0],[94,1,95,1],[96,0,97,0],[96,1,97,1],[114,0,115,0],[114,1,115,1],[116,0,118,0],[116,1,118,1],[119,1,120,1],[121,0,123,0],[121,1,123,1],[107,0,108,0],[107,1,108,1],[109,0,110,0],[109,1,110,1],[111,0,112,0],[111,1,112,1],[132,0,134,0],[132,1,134,1],[135,0,136,0],[135,1,136,1],[137,0,138,0],[137,1,138,1],[124,0,126,0],[124,1,126,1],[127,0,128,0],[127,1,128,1],[129,0,131,0],[129,1,131,1],[146,0,147,0],[146,1,149,1],[148,0,149,0],[150,0,151,0],[150,1,151,1],[156,0,157,0],[156,1,157,1],[139,0,140,0],[139,1,140,1],[141,0,142,0],[141,1,142,1],[143,0,144,0],[143,1,144,1],[160,18,160,21],[161,8,161,9],[161,10,161,11],[161,12,161,13],[161,18,161,19],[161,20,161,21],[159,0,159,21],[160,0,162,0],[160,1,162,1],[160,2,162,2],[160,3,162,3],[160,4,161,5],[160,6,161,7],[160,8,160,13],[160,14,161,15],[160,16,161,17],[170,0,171,0],[170,1,171,1],[172,0,173,0],[172,1,175,1],[174,0,175,0],[176,0,177,0],[176,1,177,1],[163,0,165,0],[163,1,165,1],[166,0,167,0],[166,1,167,1],[168,0,169,0],[168,1,169,1],[186,0,187,0],[186,1,187,1],[188,0,189,0],[188,1,191,1],[190,0,191,0],[192,0,193,0],[192,1,193,1],[178,0,179,0],[178,1,181,1],[180,0,181,0],[182,0,183,0],[182,1,183,1],[184,0,185,0],[184,1,185,1],[200,0,202,0],[200,1,202,1],[203,0,205,0],[203,1,205,1],[206,1,207,1],[208,0,209,0],[208,1,209,1],[194,0,195,0],[194,1,195,1],[196,0,197,0],[196,1,197,1],[198,0,199,0],[198,1,199,1],[220,0,220,21],[216,0,217,0],[216,1,217,1],[210,0,211,0],[210,1,211,1],[212,0,213,0],[212,1,213,1],[214,0,215,0],[214,1,215,1],[218,0,218,21]]}
["Supplementary Table 3. Study-specific descriptives for total sample from contributing studies. Abbreviations: BMI- body mass index, WHR- waist to hip ratio."]
[" GWAS Data"]
["Study","Ancestry","Groups","N","Age",null,"BMI (kg/m2)",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)",null,"Current Smoking Status"]
[{"$nulls":8},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)",{"$nulls":5}," Smoker",null,"Non-Smoker"]
[{"$nulls":4},"mean","sd","mean","sd","n","%","n","%","n","%","mean","sd","mean","sd","n","%","n","%"]
["AE","EU","Overall",627,67.7,8.84,26.3,3.65,242,38.6,307,49,78,12.4,"NA","NA","NA","NA",228,36.4,397,63.3]
[null,null,"women ",190,67.64,9.6300000000000008,26.32,4.6900000000000004,77,12.299999999999999,82,13.1,31,4.9000000000000004,"NA","NA","NA","NA",80,12.8,110,17.599999999999998]
[null,null,"men ",435,67.72,8.5,26.26,3.19,165,26.3,225,35.9,47,7.5,"NA","NA","NA","NA",148,23.7,287,45.9]
["AGES","EU","Overall",3214,76.41,5.45,27.11,4.43,1008,31.688148381012258,1465,31.688148381012258,708,22.257151839044326,100.8,12.18,"NA","NA",409,12.729999999999999,2805,87.27]
[null,null,"women ",1863,76.33,5.55,27.19,4.8499999999999996,602,32.788671023965144,788,32.788671023965144,446,24.291938997821347,99.54,13.14,"NA","NA",247,13.26,1616,86.74]
[null,null,"men ",1351,76.52,5.32,26.99,3.78,406,30.185873605947954,677,30.185873605947954,262,19.479553903345725,102.54,10.48,"NA","NA",162,11.99,1189,88.009999999999991]
["ARIC","AF","Overall",2618,53.31,5.79,29.67,6.08,547,20.89,1007,38.46,1064,40.64,99.3,15.01,0.92,0.08,781,29.799999999999997,1837,70.199999999999989]
[null,null,"women ",1649,53.18,5.67,30.66,6.51,290,17.59,581,35.229999999999997,778,47.18,100.17,16.190000000000001,0.91,0.08,416,25.23,1233,74.77]
[null,null,"men ",969,53.52,5.99,27.99,4.82,257,26.52,426,43.96,286,29.509999999999998,97.82,12.64,0.94,0.05,365,37.669999999999995,604,62.33]
["ARIC ","EU","Overall",7930,54.27,5.69,27.02,4.88,2942,37.1,3179,40.089999999999996,1809,22.81,96.19,13.39,0.93,0.08,1996,25.169999999999998,5934,74.83]
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["ORCADES","EU","Overall",889,53.49,15.73,27.67,4.84,257,29.749999999999996,377,43.63,230,26.619999999999997,93.51,13.88,0.91,0.09,373,42.730000000000004,500,57.269999999999996]
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[null,null,"women ",2720,75.66,3.4,27.07,4.66,899,33.1,1122,41.3,668,24.599999999999998,"NA","NA","NA","NA",578,21.3,2142,78.8]
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["TRAILS","EU","women ",609,19.13,0.56999999999999995,23.09,3.8,451,74.099999999999994,108,17.7,35,5.7,75.47,8.92,0.75,0.05,212,34.799999999999997,397,65.2]
[null,null,"men ",532,19.190000000000001,0.54,22.61,3.77,416,78.2,65,12.2,30,5.6,81.73,9.6999999999999993,0.82,0.05,205,38.5,326,61.5]
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["WGHS","EU","women ",22870,54.69,7.11,25.91,4.96,11695,51.1,7056,30.9,3996,17.5,88.87,14.33,0.83,0.08,2648,11.6,20222,88.4]
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[null,null,"men ",900,37.69,5.04,26.75,4.29,327,36.299999999999997,405,45,166,18.399999999999999,94.44,12.01,0.94,7.0000000000000007E-2,206,22.900000000000002,694,77.099999999999994]
[]
["METBOCHIP  Data"]
["Study","Ancestry","Groups","N","Age",null,"BMI (kg/m2)",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)",null,"Current Smoking Status"]
[{"$nulls":8},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)",{"$nulls":5}," Smoker",null,"Non-Smoker"]
[{"$nulls":4},"mean","sd","mean","sd","n","%","n","%","n","%","mean","sd","mean","sd","n","%","n","%"]
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[null,null,"women ",1968,46.38,10.32,24.79,4.29,1160,58.999999999999993,565,28.74,241,12.26,78.87,10.72,0.8,7.0000000000000007E-2,362,18.39,1606,81.61]
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["DR's EXTRA","EU","women ",621,66.47,5.25,27.57,5.04,215,34.599999999999994,246,39.6,160,25.8,88.71,13.1,0.87,6.7000000000000004E-2,44,7.1,577,92.9]
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["INTER99","EU","women ",3036,45.94,7.9,25.76,5.07,1582,52.1,919,30.299999999999997,505,16.600000000000001,80.3,12.33,0.8,0.06,1075,35.4,1961,64.599999999999994]
[null,null,"men ",2907,46.66,7.72,26.82,4.0199999999999996,996,34.300000000000004,1403,48.199999999999996,503,17.299999999999997,93.26,11.04,0.92,0.06,1070,36.799999999999997,1837,63.2]
["KORAS3","EU","women ",659,40.89,12.66,25.18,4.72,387,58.699999999999996,173,26.3,98,14.899999999999999,79.12,11.24,0.78,0.06,473,71.8,186,28.199999999999996]
[null,null,"men ",599,40.58,13.14,26.54,3.43,207,34.599999999999994,305,50.9,87,14.499999999999998,92.8,9.33,0.9,0.06,392,65.400000000000006,207,34.599999999999994]
["KORAS4","EU","women ",624,41.35,14.82,25.94,5.09,294,47.099999999999994,223,35.699999999999996,107,17.100000000000001,82.16,12,0.79,0.06,476,76.3,148,23.7]
[null,null,"men ",582,42.49,15.74,26.64,3.59,197,33.800000000000004,295,50.7,90,15.5,94.34,10,0.9,0.06,389,66.8,193,33.200000000000003]
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[null,null,"men ",258,71.260000000000005,7.97,26.91,4.9000000000000004,87,33.720930232558139,116,44.961240310077521,52,20.155038759689923,97.37,12.82,0.94,0.09,42,16.279069767441861,216,83.720930232558146]
["METSIM-controls","EU","men ",899,53.94,4.99,26.4,3.39,313,34.799999999999997,468,52.1,118,13.1,95.83,9.6999999999999993,0.95399999999999996,5.8999999999999997E-2,145,16.100000000000001,754,83.899999999999991]
["METSIM-T2D cases",null,"men ",1143,60.53,6.63,30.17,5.15,150,13.1,480,42,513,44.9,107.14,13.33,1.0189999999999999,7.0000000000000007E-2,181,15.8,962,84.199999999999989]
["NSHD","EU","women ",1213,53,0,27.35,5.23,454,37.4,459,37.799999999999997,300,24.7,85.59,12.53,0.81,7.0000000000000007E-2,295,24.299999999999997,918,75.7]
[null,null,"men ",1216,53,0,27.36,3.93,340,28.000000000000004,612,50.3,264,21.7,97.66,10.44,0.94,0.06,298,24.5,918,75.5]
["SCARSHEEP cases","EU","women ",402,60.03,7.35,27.02,4.97,148,36.9,149,37.199999999999996,104,25.9,90.3,13.52,0.87,0.08,142,35.299999999999997,260,64.7]
[null,null,"men ",1120,56.76,7.13,26.92,3.63,341,30.7,569,51.3,199,17.899999999999999,99,9.92,0.97,0.06,442,39.5,678,60.5]
["SCARSHEEP controls","EU","women ",554,60.72,7.07,25.57,4.0599999999999996,275,50.199999999999996,199,36.299999999999997,74,13.5,86.32,11.86,0.85,0.09,176,31.8,378,68.2]
[null,null,"men ",1334,57.55,7.05,25.86,3.48,567,42.6,612,46,151,11.4,95.98,9.77,0.96,7.0000000000000007E-2,371,27.8,963,72.2]
["SPT","JAMAICA","women ",553,45.59,13.06,28.41,6.06,157,28.389999999999997,193,34.9,203,36.699999999999996,84.24,12.47,1,0,66,11.93,487,88.070000000000007]
[null,null,"men ",351,47.95,14.81,24.29,4.34,251,71.5,103,29.34,33,9.4,82.77,12.53,0.85399999999999998,0.88300000000000001,116,33.050000000000004,235,66.95]
["WHITEHALL","EU","women ",708,61.01,6.12,27.12,5.63,277,39.1,255,36,176,24.9,83.69,13.22,0.81,7.0000000000000007E-2,69,9.6999999999999993,639,90.3]
[null,null,"men ",2345,60.64,5.91,26.62,3.67,793,33.800000000000004,1179,50.3,373,15.9,94.35,10.49,0.94,7.0000000000000007E-2,152,6.5,2193,93.5]
["VALIDATION  Data"]
["UKBB","EU","combined",118634,56.93,7.93,27.536200000000001,4.8278249999999998,37551,31.7,50468,42.5,29680,25,90.81,13.6,0.87503569999999997,9.0556800000000007E-2,13416,11.3,105218,88.69]
["* BMI categories will not add up to the total sample size (N) in studies that excluded underweight (BMI<18.5) individuals. "]

{"sheet":"ST4. Study Descriptives by SMK","index":3,"n_rows":226,"n_cols":34,"rows_kept":226,"cut":false,"hidden":false,"merged":[[219,0,219,33],[220,0,220,17],[220,20,220,33],[221,0,223,0],[221,1,223,1],[221,2,223,2],[221,3,223,3],[221,4,222,5],[221,6,222,7],[221,8,221,13],[221,14,222,15],[221,16,222,17],[221,19,223,19],[221,20,222,21],[221,22,222,23],[221,24,221,29],[221,30,222,31],[221,32,222,33],[222,8,222,9],[222,10,222,11],[222,12,222,13],[222,24,222,25],[222,26,222,27],[222,28,222,29],[1,0,1,33],[2,3,2,17],[2,20,2,33],[3,0,5,0],[3,1,5,1],[3,2,5,2],[3,3,5,3],[3,4,4,5],[3,6,4,7],[3,24,3,29],[3,30,4,31],[3,32,4,33],[4,8,4,9],[4,10,4,11],[4,12,4,13],[4,24,4,25],[4,26,4,27],[4,28,4,29],[3,8,3,13],[3,14,4,15],[3,16,4,17],[3,19,5,19],[3,20,4,21],[3,22,4,23],[15,0,17,0],[15,1,17,1],[19,0,20,0],[19,1,20,1],[21,0,23,0],[21,1,23,1],[6,0,8,0],[6,1,8,1],[9,0,11,0],[9,1,11,1],[12,0,14,0],[12,1,14,1],[32,0,33,0],[32,1,33,1],[34,0,35,0],[34,1,35,1],[37,0,38,0],[37,1,38,1],[24,0,26,0],[24,1,26,1],[27,0,29,0],[27,1,29,1],[30,0,31,0],[30,1,31,1],[48,0,49,0],[48,1,49,1],[50,0,51,0],[50,1,51,1],[52,0,53,0],[52,1,53,1],[39,0,41,0],[39,1,41,1],[42,0,44,0],[42,1,44,1],[45,0,47,0],[45,1,47,1],[63,0,65,0],[63,1,65,1],[66,0,67,0],[66,1,69,1],[68,0,69,0],[70,0,72,0],[70,1,72,1],[55,0,56,0],[55,1,56,1],[57,0,59,0],[57,1,59,1],[60,0,62,0],[60,1,62,1],[85,0,86,0],[85,1,86,1],[87,0,88,0],[87,1,88,1],[89,0,90,0],[89,1,92,1],[91,0,92,0],[73,0,75,0],[73,1,75,1],[76,0,78,0],[76,1,78,1],[80,1,81,1],[82,0,84,0],[82,1,84,1],[99,0,100,0],[99,1,100,1],[101,0,102,0],[101,1,102,1],[104,0,105,0],[104,1,107,1],[106,0,107,0],[93,0,94,0],[93,1,94,1],[95,0,96,0],[95,1,96,1],[97,0,98,0],[97,1,98,1],[115,0,116,0],[115,1,116,1],[117,0,119,0],[117,1,119,1],[120,1,121,1],[122,0,124,0],[122,1,124,1],[108,0,109,0],[108,1,109,1],[110,0,111,0],[110,1,111,1],[112,0,113,0],[112,1,113,1],[133,0,135,0],[133,1,135,1],[136,0,137,0],[136,1,137,1],[138,0,139,0],[138,1,139,1],[125,0,127,0],[125,1,127,1],[128,0,129,0],[128,1,129,1],[130,0,132,0],[130,1,132,1],[146,0,147,0],[146,1,149,1],[148,0,149,0],[150,0,151,0],[150,1,151,1],[156,0,157,0],[156,1,157,1],[140,0,141,0],[140,1,141,1],[142,0,143,0],[142,1,143,1],[144,0,145,0],[144,1,145,1],[159,0,159,33],[160,0,160,17],[160,20,160,33],[161,0,163,0],[161,1,163,1],[161,2,163,2],[161,3,163,3],[161,4,162,5],[161,6,162,7],[161,8,161,13],[164,0,166,0],[164,1,166,1],[167,0,168,0],[167,1,168,1],[169,0,170,0],[169,1,170,1],[161,30,162,31],[161,32,162,33],[162,8,162,9],[162,10,162,11],[162,12,162,13],[162,24,162,25],[162,26,162,27],[162,28,162,29],[161,14,162,15],[161,16,162,17],[161,19,163,19],[161,20,162,21],[161,22,162,23],[161,24,161,29],[179,0,180,0],[179,1,182,1],[181,0,182,0],[183,0,184,0],[183,1,184,1],[185,0,186,0],[185,1,186,1],[171,0,172,0],[171,1,172,1],[173,0,174,0],[173,1,176,1],[175,0,176,0],[177,0,178,0],[177,1,178,1],[195,0,196,0],[195,1,196,1],[197,0,198,0],[197,1,198,1],[199,0,200,0],[199,1,200,1],[187,0,188,0],[187,1,188,1],[189,0,190,0],[189,1,192,1],[191,0,192,0],[193,0,194,0],[193,1,194,1],[217,0,218,0],[217,1,218,1],[211,0,212,0],[211,1,212,1],[213,0,214,0],[213,1,214,1],[215,0,216,0],[215,1,216,1],[201,0,203,0],[201,1,203,1],[204,0,206,0],[204,1,206,1],[207,1,208,1],[209,0,210,0],[209,1,210,1]]}
["Supplementary Table 4. Study-specific descriptives from contributing studies stratified by smoking status. Abbreviations: BMI- body mass index, WHR- waist to hip ratio."]
["GWAS Data"]
[null,null,null,"SMOKERS",{"$nulls":16},"NON-SMOKERS"]
["Study","Ancestry","Groups","N","Age",null,"BMI",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)",null,null,"N","Age",null,"BMI",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)"]
[{"$nulls":8},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)",{"$nulls":11},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)"]
[{"$nulls":4},"mean","sd","mean","sd","n","%","n","%","n","%","mean","sd","mean","sd",null,null,"mean","sd","mean","sd","n","%","n","%","n","%","mean","sd","mean","sd"]
["AE","EU","Overall",228,64.58,8.4459999999999997,25.576699999999999,3.6026099999999999,107,46.9,101,44.3,20,8.8000000000000007,"NA","NA","NA","NA",null,397,69.45,8.5670000000000002,26.689299999999999,3.71712,133,33.5,206,51.9,58,14.6,"NA","NA","NA","NA"]
[null,null,"women ",80,64.75,9.1519999999999992,25.171800000000001,3.9867400000000002,39,48.8,33,41.3,8,10,"NA","NA","NA","NA",null,110,69.739999999999995,9.4649999999999999,26.2134,4.99491,38,34.5,49,44.5,23,20.9,"NA","NA","NA","NA"]
[null,null,"men ",148,64.48,8.0779999999999994,25.795500000000001,3.3708999999999998,68,46,68,45.9,12,8.1,"NA","NA","NA","NA",null,287,69.34,8.2140000000000004,26.509899999999998,3.0832000000000002,95,33.1,157,54.7,35,12.2,"NA","NA","NA","NA"]
["AGES","EU","Overall",409,74.5,4.9000000000000004,25.8,4.4000000000000004,167,40.83,166,40.590000000000003,65,15.89,98.1,12.4,"NA","NA",null,2805,76.680000000000007,5.48,27.29,4.4000000000000004,841,30.21918792669781,1299,46.676248652533232,643,23.104563420768951,101.19,12.1,"NA","NA"]
[null,null,"women ",247,74.599999999999994,4.9000000000000004,25.9,4.8,98,39.68,94,38.06,46,18.62,97.2,13.3,"NA","NA",null,1616,76.59,5.59,27.39,4.83,504,31.539424280350435,694,43.429286608260327,400,25.031289111389238,99.89,13.07,"NA","NA"]
[null,null,"men ",162,74.5,4.9000000000000004,25.7,3.8,69,42.59,72,44.44,19,11.73,99.5,10.7,"NA","NA",null,1189,76.8,5.31,27.16,3.75,337,28.43881856540084,605,51.054852320675103,243,20.50632911392405,102.96,10.38,"NA","NA"]
["ARIC","AF","Overall",781,53,5.7,27.8,5.5,245,31.4,308,39.4,228,29.2,96.1,13.8,0.92,7.0000000000000007E-2,null,1837,53.45,5.85,30.48,6.13,302,16.439999999999998,699,38.049999999999997,836,45.51,100.68,15.3,0.92,0.08]
[null,null,"women ",416,52.7,5.4,28.6,6,115,27.6,154,37,147,35.299999999999997,96.8,15.1,0.91,0.08,null,1233,53.35,5.74,31.35,6.52,175,14.19,427,34.629999999999995,631,51.18,101.31,16.38,0.9,0.08]
[null,null,"men ",365,53.3,5.9,26.8,4.5999999999999996,130,35.599999999999994,154,42.199999999999996,81,22.2,95.2,12,0.94,0.06,null,604,53.65,6.05,28.71,4.8,127,21.029999999999998,272,45.029999999999994,205,33.94,99.41,12.76,0.95,0.05]
["ARIC ","EU","Overall",1996,53.6,5.5,25.8,4.5999999999999996,951,47.699999999999996,713,35.699999999999996,332,16.600000000000001,94,13.1,0.93,0.08,null,5934,54.51,5.73,27.43,4.92,1991,33.550000000000004,2466,41.56,1477,24.89,96.94,13.42,0.93,0.08]
[null,null,"women ",1091,53.3,5.6,25.2,4.9000000000000004,617,56.599999999999994,295,27,179,16.399999999999999,90.5,13.9,0.89,0.08,null,3097,54.16,5.69,27.11,5.64,1330,42.94,972,31.39,795,25.669999999999998,93.92,15.08,0.89,0.08]
[null,null,"men ",905,53.9,5.5,26.6,4,334,36.9,418,46,153,16.900000000000002,98.2,10.6,0.97,0.05,null,2831,54.89,5.76,27.77,3.96,661,23.3,1494,52.66,682,24.04,100.23,10.37,0.97,0.05]
["AUSTWIN","EU","Overall",448,42.6,11.4,25.8,4.5999999999999996,205,45.800000000000004,166,37.1,72,16.100000000000001,"NA","NA","NA","NA",null,1718,53.06,15.47,27.05,5.16,658,38.5,663,38.799999999999997,387,22.7,"NA","NA","NA","NA"]
["BHS","EU","women ",55,45.8,16.7,27,4.5999999999999996,22,40,19,34.5,14,25.5,84.2,12,0.81,7.0000000000000007E-2,null,590,55.23,16.63,25.44,4.38,316,53.6,177,30,93,15.8,80.66,11.5,0.8,7.0000000000000007E-2]
[null,null,"men ",54,45.1,15.5,26.2,3.9,26,33.300000000000004,18,33.300000000000004,10,18.5,91.8,10.5,0.93,7.0000000000000007E-2,null,359,54.75,16.78,26.63,3.64,124,34.5,171,47.599999999999994,61,17,93.62,10.46,0.93,0.06]
["BIOME","AF","Overall",905,50.8,12.7,29.5,7.7,264,29.2,266,29.4,358,39.6,"NA","NA","NA","NA",null,2587,52.24,15.56,30.78,8.07,598,23.119999999999997,787,30.42,1170,45.23,"NA","NA","NA","NA"]
[null,null,"women ",478,51.9,12.8,30.9,8.1,106,22.2,126,26.400000000000002,233,48.699999999999996,"NA","NA","NA","NA",null,1771,52.28,15.92,31.7,8.68,379,21.4,479,27.05,885,49.97,"NA","NA","NA","NA"]
[null,null,"men ",427,49.5,12.4,27.9,6.8,158,37,140,32.799999999999997,125,29.299999999999997,"NA","NA","NA","NA",null,816,52.14,14.77,28.78,6.1,219,26.840000000000003,308,37.75,285,34.93,"NA","NA","NA","NA"]
["BIOME","EU","Overall",168,64.400000000000006,8,27.6,5.5,48,28.599999999999998,74,44.1,44,26.2,"NA","NA","NA","NA",null,1849,68.069999999999993,9.34,26.85,5.43,727,39.32,668,36.130000000000003,435,23.53,"NA","NA","NA","NA"]
[null,null,"women ",55,63.6,8.9,26.7,6,22,40,17,30.9,15,27.3,"NA","NA","NA","NA",null,913,67.47,9.06,25.93,5.7,441,48.3,264,28.92,191,20.919999999999998,"NA","NA","NA","NA"]
[null,null,"men ",113,64.7,7.5,28,5.3,26,23,57,50.4,29,25.7,"NA","NA","NA","NA",null,936,68.66,9.58,27.74,5,286,30.56,404,43.16,244,26.069999999999997,"NA","NA","NA","NA"]
["BIOME","HS","Overall",921,49.2,13.3,29.2,6.5,239,26,315,34.200000000000003,358,38.9,"NA","NA","NA","NA",null,3787,55.55,16.47,29.44,6.67,967,25.53,1310,34.589999999999996,1484,39.190000000000005,"NA","NA","NA","NA"]
[null,null,"women ",475,49.1,13.5,29.9,6.8,119,25.099999999999998,140,29.499999999999996,212,44.6,"NA","NA","NA","NA",null,2469,55.19,16.62,29.7,6.98,639,25.879999999999995,782,31.669999999999998,1028,41.64,"NA","NA","NA","NA"]
[null,null,"men ",446,49.4,13.2,28.6,6.1,120,26.900000000000002,175,39.200000000000003,146,32.700000000000003,"NA","NA","NA","NA",null,1318,56.22,16.149999999999999,28.96,6.01,328,24.89,528,40.06,456,34.599999999999994,"NA","NA","NA","NA"]
["BLSA","EU","women ","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA",null,372,66.760000000000005,17.03,25.92,4.84,193,51.88,109,29.3,70,18.82,84.49,11.67,0.82,7.3999999999999996E-2]
[null,null,"men ","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA","NA",null,441,71.53,15.7,27.54,4.5599999999999996,139,31.52,191,43.31,111,25.17,98.54,12.17,0.95,6.5000000000000002E-2]
["B58C","EU","women ",809,45.2,0.4,26.7,5.5,366,45.2,249,30.8,186,23,85.7,13,0.83,0.06,null,2446,45.16,0.38,27,5.52,1060,43.3,814,33.300000000000004,565,23.1,85.19,12.47,0.81,0.06]
[null,null,"men ",732,45.2,0.4,27.3,4.3,230,31.4,312,42.6,185,25.3,97.9,11.2,0.94,0.06,null,2494,45.17,0.38,28.05,4.24,561,22.5,1282,51.4,649,26,98.85,11.08,0.93,0.06]
["CHS","EU","women ",229,70.099999999999994,3.8,25.4,4.5,127,55.500000000000007,67,29.299999999999997,35,15.299999999999999,89.4,12.8,0.89,0.08,null,1656,72.14,5.26,26.63,4.78,681,41.12,646,39.01,329,19.869999999999997,91.08,13.51,0.89,9.5000000000000001E-2]
[null,null,"men ",119,71,4.9000000000000004,25.4,3.2,54,45.4,59,49.6,6,5,96,9.4,0.96,0.06,null,1111,73.16,5.62,26.52,3.51,391,35.19,545,49.05,175,15.75,97.82,9.73,0.96,5.8000000000000003E-2]
["CLHNS","AS","women ",267,49.6,7.1,23.1,4.8,181,67.8,59,22.1,27,10.1,78.3,11.6,0.88,0.05,null,1526,48.25,5.9,24.53,4.25,848,55.569999999999993,522,34.21,156,10.219999999999999,81.59,10.67,0.88,0.05]
["COLAUS","EU","women ",699,52.04,9.8699999999999992,23.98,4.34,444,63.519313304721024,168,24.034334763948497,87,12.446351931330479,64.05,11.84,0.65,6.8000000000000005E-2,null,2176,54.49,10.91,25.545000000000002,5.0049999999999999,1146,52.665441176470587,653,30.009191176470591,377,17.325367647058819,67.23,13.195,0.65700000000000003,7.0000000000000007E-2]
[null,null,"men ",734,51.18,10.39,26.23,3.77,292,39.782016348773844,331,45.095367847411445,111,15.12261580381471,80.349999999999994,12.68,0.78500000000000003,7.9600000000000004E-2,null,1826,53.64,10.84,26.785,4.0970000000000004,646,35.377875136911278,839,45.947426067907998,341,18.674698795180724,82,13.48,0.78900000000000003,0.08]
["CROATIA-KORCULA","EU","Overall",203,48.3,12,26.9,4.4000000000000004,72,35.799999999999997,89,44.3,40,19.900000000000002,90.8,12.7,0.89,0.09,null,683,58.45,13.6,28.29,4.0199999999999996,133,19.850000000000001,323,48.209999999999994,214,31.94,95.27,11.81,0.91,0.08]
[null,null,"women ",140,47.7,"11,14",26.4,4.4000000000000004,57,41.3,58,42,23,16.7,87.8,12,0.86,0.08,null,425,57.89,13.48,27.87,4.2699999999999996,107,25.48,190,45.24,123,29.29,91.95,11.7,0.88,0.08]
[null,null,"men ",63,49.6,13.7,27.9,4.0999999999999996,15,23.799999999999997,31,49.199999999999996,17,26,97.4,11.6,0.94,0.08,null,258,59.36,13.76,28.99,3.46,26,10.399999999999999,133,53.2,91,36.4,100.84,9.73,0.96,7.0000000000000007E-2]
["CROTIA-VIS","EU","Overall",255,47.6,14.5,26.1,4.5,105,42.199999999999996,98,39.4,46,18.5,92.2,12.5,0.91,0.08,null,660,59.69,14.57,27.78,4.1100000000000003,165,25.19,297,45.34,193,29.470000000000002,97.21,11.24,0.94,0.08]
[null,null,"women ",136,46.5,13.7,25.9,4.9000000000000004,62,46.999999999999993,43,32.6,27,20.5,89.8,13.3,0.88,0.08,null,393,60.15,15.19,27.63,4.47,117,30.080000000000002,151,38.82,121,31.11,95.64,12.23,0.92,0.09]
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[]
["METABOCHIP Data"]
["SMOKERS",{"$nulls":19},"NON-SMOKERS"]
["Study","Ancestry","Groups","N","Age",null,"BMI",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)",null,null,"N","Age",null,"BMI",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)"]
[{"$nulls":8},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)",{"$nulls":11},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)"]
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["VALIDATION Data"]
["SMOKERS",{"$nulls":19},"NON-SMOKERS"]
["Study","Ancestry","Groups","N","Age",null,"BMI",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)",null,null,"N","Age",null,"BMI",null,"BMI Categories*",{"$nulls":5},"Waist (cm)",null,"WHR (ratio)"]
[{"$nulls":8},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)",{"$nulls":11},"Normal weight                        (18 to < 25 kg/m2)",null,"Overweight                           (25 to 30 kg/m2)",null,"Obese                                    ( ≥ 30 kg/m2)"]
[{"$nulls":4},"mean","sd","mean","sd","n","%","n","%","n","%","mean","sd","mean","sd",null,null,"mean","sd","mean","sd","n","%","n","%","n","%","mean","sd","mean","sd"]
["UKBB","EU","combined",13416,54.914059999999999,8.0028880000000004,26.996169999999999,4.8998299999999997,4800,35.78,5384,40.130000000000003,3007,22.42,90.866050000000001,13.59,0.88950890000000005,8.8024599999999995E-2,null,105218,57.188009999999998,7.888795,27.60493,4.8142649999999998,32751,31.1,45084,42.85,26673,25.35,90.800820000000002,13.611800000000001,0.87319150000000001,9.0708999999999998E-2]
[null,null,null,"*BMI categories will not add up to the total sample size (N) in studies that excluded underweight (BMI<18.5) individuals. "]

{"sheet":"SD 1. BMI All Ancestries","index":4,"n_rows":104,"n_cols":59,"rows_kept":104,"cut":false,"hidden":false,"merged":[[2,5,2,8],[2,9,2,10],[2,48,2,52],[2,54,2,58],[1,43,1,58],[2,43,2,47],[1,11,1,26],[1,27,1,42],[2,11,2,15],[2,16,2,20],[2,22,2,26],[2,27,2,31],[2,32,2,36],[2,38,2,42],[2,21,3,21],[2,37,3,37],[2,53,3,53]]}
["Supplementary Data 1. BMI association results for all ancestries meta-analyses. Significant SNPs for BMI across all approaches (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only) for combined ancestries meta-analyses. Summary statistics are presented from stage1 plus stage 2 results."]
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[]
[]
[]
[{"$nulls":12},{"$f":"-LOG10(5E-20)","v":19.301029995663981}]

{"sheet":"SD 2. WC All Ancestries","index":5,"n_rows":123,"n_cols":59,"rows_kept":123,"cut":false,"hidden":false,"merged":[[2,5,2,8],[2,27,2,31],[1,11,1,26],[1,27,1,42],[1,43,1,58],[2,9,2,10],[2,11,2,15],[2,16,2,20],[2,22,2,26],[2,32,2,36],[2,38,2,42],[2,43,2,47],[2,48,2,52],[2,54,2,58],[2,37,3,37],[2,53,3,53],[2,21,3,21]]}
["Supplementary Data 2. Significant SNPs for WCadjBMI across all approaches (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only) for combined ancestries meta-analyses. Summary statistics are presented from stage1 plus stage 2 results."]
[{"$nulls":11},"SMOKERS",{"$nulls":15},"NON-SMOKERS",{"$nulls":15},"Main and Interaction Effects"]
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{"sheet":"SD 3. WHR All Ancestries","index":6,"n_rows":76,"n_cols":59,"rows_kept":76,"cut":false,"hidden":false,"merged":[[2,5,2,8],[1,11,1,26],[1,27,1,42],[1,43,1,58],[2,9,2,10],[2,11,2,15],[2,16,2,20],[2,22,2,26],[2,54,2,58],[2,27,2,31],[2,32,2,36],[2,38,2,42],[2,43,2,47],[2,48,2,52],[2,37,3,37],[2,53,3,53],[2,21,3,21]]}
["Supplementary TData 3. Significant SNPs for WHRadjBMI across all approaches (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only) for combined ancestries meta-analyses. Summary statistics are presented from stage1 plus stage 2 results."]
[{"$nulls":11},"SMOKERS",{"$nulls":15},"NON-SMOKERS",{"$nulls":15},"Main and Interaction Effects"]
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{"sheet":"SD 4. BMI_EUR Only","index":7,"n_rows":93,"n_cols":59,"rows_kept":93,"cut":false,"hidden":false,"merged":[[2,5,2,8],[1,11,1,26],[1,27,1,42],[1,43,1,58],[2,9,2,10],[2,11,2,15],[2,16,2,20],[2,22,2,26],[2,27,2,31],[2,32,2,36],[2,38,2,42],[2,43,2,47],[2,48,2,52],[2,54,2,58],[2,37,3,37],[2,53,3,53],[2,21,3,21]]}
["Supplementary Data 4. Significant SNPs for BMI across all approaches (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only) for European-only analyses. Summary statistics are presented from stage1 plus stage 2 results."]
[{"$nulls":11},"SMOKERS",{"$nulls":15},"NON-SMOKERS",{"$nulls":15},"Main and Interaction Effects"]
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{"sheet":"SD 5. WC_EUR Only","index":8,"n_rows":113,"n_cols":59,"rows_kept":113,"cut":false,"hidden":false,"merged":[[3,5,3,8],[2,11,2,26],[2,27,2,42],[2,43,2,58],[3,9,3,10],[3,11,3,15],[3,16,3,20],[3,22,3,26],[3,27,3,31],[3,32,3,36],[3,38,3,42],[3,43,3,47],[3,48,3,52],[3,54,3,58],[3,37,4,37],[3,53,4,53],[3,21,4,21]]}
[]
["Supplementary Data 5. Significant SNPs for WCadjBMI across all approaches (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only) for European-only analyses. Summary statistics are presented from stage1 plus stage 2 results."]
[{"$nulls":11},"SMOKERS",{"$nulls":15},"NON-SMOKERS",{"$nulls":15},"Main and Interaction Effects"]
[{"$nulls":5},"Approaches",null,null,null,"Alleles",null,"WOMEN",{"$nulls":4},"MEN",{"$nulls":4},"PSexdiff","COMBINED",{"$nulls":4},"WOMEN",{"$nulls":4},"MEN",{"$nulls":4},"PSexdiff","COMBINED",{"$nulls":4},"WOMEN",{"$nulls":4},"MEN",{"$nulls":4},"PSexdiff","COMBINED"]
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{"sheet":"SD 6. WHR_EUR Only","index":9,"n_rows":79,"n_cols":59,"rows_kept":79,"cut":false,"hidden":false,"merged":[[2,54,2,58],[2,21,3,21],[2,37,3,37],[2,53,3,53],[0,0,0,52],[1,11,1,26],[1,27,1,42],[1,43,1,58],[2,5,2,8],[2,9,2,10],[2,11,2,15],[2,16,2,20],[2,22,2,26],[2,27,2,31],[2,32,2,36],[2,38,2,42],[2,43,2,47],[2,48,2,52]]}
["Supplementary Data 6. Significant SNPs for WHRadjBMI across all approaches (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only) for European-only analyses. Summary statistics are presented from stage1 plus stage 2 results."]
[{"$nulls":11},"SMOKERS",{"$nulls":15},"NON-SMOKERS",{"$nulls":15},"Main and Interaction Effects"]
[{"$nulls":5},"Approaches",null,null,null,"Alleles",null,"WOMEN",{"$nulls":4},"MEN",{"$nulls":4},"PSexdiff","COMBINED",{"$nulls":4},"WOMEN",{"$nulls":4},"MEN",{"$nulls":4},"PSexdiff","COMBINED",{"$nulls":4},"WOMEN",{"$nulls":4},"MEN",{"$nulls":4},"PSexdiff","COMBINED"]
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["Supplementary Data 7. Lookups of previously identified BMI main effects loci in the current combined ancestries meta-analyses results for BMI."]
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{"sheet":"SD 7B. KnownLoci_WCadjBMI","index":11,"n_rows":81,"n_cols":47,"rows_kept":81,"cut":false,"hidden":false,"merged":[[1,32,1,46],[2,0,3,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,6],[2,7,3,7],[2,32,2,36],[2,37,2,41],[2,42,2,46],[2,8,2,11],[2,12,2,15],[2,16,2,19],[2,20,2,23],[2,24,2,27],[2,28,2,31],[1,8,1,19],[1,20,1,31]]}
["Supplementary Data 7B. Lookups of previously identified WCadjBMI main effects loci in current combined ancestries meta-analyses results for WCadjBMI."]
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{"sheet":"SD 7C. KnownLoci_WHRadjBMI","index":12,"n_rows":70,"n_cols":47,"rows_kept":70,"cut":false,"hidden":false,"merged":[[1,32,1,46],[2,0,3,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,6],[2,7,3,7],[2,32,2,36],[2,37,2,41],[2,42,2,46],[2,8,2,11],[2,12,2,15],[2,16,2,19],[2,20,2,23],[2,24,2,27],[2,28,2,31],[1,8,1,19],[1,20,1,31]]}
["Supplementary Data 7C. Lookups of previously identified WHRadjBMI main effects loci in the current combined ancestries meta-analyses results for WHRadjBMI."]
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["rs2925979",16,80092291,"CMIP","W","T","C",0.30649999999999999,18218,8.3999999999999995E-3,6.6E-3,0.2072,19463,6.8999999999999999E-3,5.4000000000000003E-3,0.19889999999999999,37681,7.4000000000000003E-3,4.1999999999999997E-3,7.3760000000000006E-2,68707.899999999994,1.67E-2,3.8E-3,1.0879999999999999E-5,59507.9,6.8999999999999999E-3,5.3E-3,0.18770000000000001,128216,1.32E-2,3.2000000000000002E-3,3.5429999999999998E-5,3.5700000000000003E-2,5.4999999999999997E-3,1.0110000000000001E-10,0.26510935000000002,2.847E-5,1.1999999999999999E-3,5.5999999999999999E-3,0.82469999999999999,1,0.18941543,1.9300000000000001E-2,4.0000000000000001E-3,1.649E-6,0.25643428000000001,4.2759999999999997E-5]
["rs8066985",17,65964940,"KCNJ2","W","A","G",0.48570000000000002,20611.3,2.8E-3,5.4000000000000003E-3,0.61209999999999998,19576.099999999999,9.1000000000000004E-3,5.1000000000000004E-3,7.2889999999999996E-2,40187.4,6.1000000000000004E-3,3.8E-3,0.1071,85301.3,1.2999999999999999E-2,3.3E-3,8.8949999999999994E-5,60657.7,3.3999999999999998E-3,4.7999999999999996E-3,0.48099999999999998,145959,9.9000000000000008E-3,2.8E-3,4.2430000000000001E-4,2.81E-2,4.4999999999999997E-3,6.3369999999999999E-10,9.9116060000000006E-2,3.7303E-4,1.2699999999999999E-2,5.1999999999999998E-3,1.374E-2,0.40796153000000002,0.15838036,2.1499999999999998E-2,3.3999999999999998E-3,2.5459999999999998E-10,0.40570487,5.3189000000000003E-4]
["rs12454712",18,58996864,"BCL2","W","T","C",0.61529999999999996,13634,1.9E-2,6.4000000000000003E-3,3.1979999999999999E-3,15049,-6.7000000000000002E-3,5.1999999999999998E-3,0.19400000000000001,28683,3.5999999999999999E-3,4.1000000000000003E-3,0.38190000000000002,53417,4.0000000000000001E-3,3.7000000000000002E-3,0.27939999999999998,48621,-7.0000000000000001E-3,5.5999999999999999E-3,0.2049,102038,5.9999999999999995E-4,3.0999999999999999E-3,0.85699999999999998,3.04E-2,6.7999999999999996E-3,6.6850000000000004E-6,3.7998110000000002E-2,6.7981400000000003E-3,-3.3E-3,6.7000000000000002E-3,0.624,0.96816254000000002,0.19962462,1.38E-2,4.7999999999999996E-3,4.071E-3,0.54653837000000005,0.66750038]

{"sheet":"ST 5. Conditional_App1","index":13,"n_rows":56,"n_cols":19,"rows_kept":56,"cut":false,"hidden":false,"merged":[[50,4,52,4],[50,5,52,5],[53,1,54,1],[53,2,54,2],[53,3,54,3],[53,4,54,4],[53,5,54,5],[2,0,14,0],[8,1,8,18],[10,1,10,18],[15,0,54,0],[16,1,17,1],[16,2,16,5],[16,6,16,7],[16,10,16,12],[16,13,16,15],[16,16,16,18],[18,1,18,18],[19,1,20,1],[19,2,20,2],[50,1,52,1],[50,2,52,2],[50,3,52,3],[33,1,36,1],[33,2,36,2],[33,3,36,3],[33,4,36,4],[33,5,36,5],[37,1,38,1],[37,2,38,2],[37,3,38,3],[37,4,38,4],[37,5,38,5],[3,16,3,18],[2,16,2,18],[44,1,49,1],[44,2,49,2],[44,3,49,3],[44,4,49,4],[44,5,49,5],[19,3,20,3],[19,4,20,4],[19,5,20,5],[21,1,21,18],[40,1,43,1],[40,2,43,2],[40,3,43,3],[40,4,43,4],[40,5,43,5],[22,5,31,5],[3,1,4,1],[3,2,3,5],[3,10,3,12],[3,13,3,15],[22,1,31,1],[0,0,1,18],[15,13,15,15],[2,13,2,15],[5,1,5,18],[32,1,32,18],[13,1,14,1],[13,2,14,2],[13,3,14,3],[13,4,14,4],[13,5,14,5],[13,6,14,6],[13,7,14,7],[15,16,15,18],[22,2,31,2],[22,3,31,3],[22,4,31,4]]}
["Supplementary Table 5. Results for approximate conditional analyses to identify secondary signals and to determine independence from previously-identified anthropometric-associated SNPs for novel loci identified in Approach 1 (SNPadjSMK). *The top variant after conditioning differed between ARIC and FHS for rs6012558."]
[]
["Secondary Signals",{"$nulls":12},"ARIC reference panel",null,null,"FHS reference panel"]
[null,"Chr","Tag SNP (TS)",null,null,null,"Condition on","Most Significant\nafter conditioning",null,null,"Before Conditioning",null,null,"After Conditioning",null,null,"After Conditioning"]
[null,null,"Marker","β","SE","P","TS Marker","Marker","Distance","r2","β","SE","P","β","SE","P","β","SE","P"]
[null,"BMI"]
[null,3,"rs6794880",2.81E-2,5.1000000000000004E-3,4.3219999999999999E-8,"rs6794880","rs7627971",962779,5.5639799999999996E-3,1.6899999999999998E-2,4.3E-3,7.9499999999999994E-5,1.62145E-2,4.29839E-3,1.61793E-4,1.5362199999999999E-2,4.2911199999999998E-3,3.4360100000000002E-4]
[null,6,"rs4498364",-2.3099999999999999E-2,4.0000000000000001E-3,7.2049999999999998E-9,"rs4498364","rs13213457",945919,5.3425100000000002E-4,-2.0400000000000001E-2,4.8999999999999998E-3,3.0300000000000001E-5,-2.04599E-2,4.9002000000000004E-3,2.97569E-5,-1.9836199999999998E-2,4.89924E-3,5.1475799999999999E-5]
[null,"WHRadjBMI"]
[null,6,"rs1049281",-2.4799999999999999E-2,4.1999999999999997E-3,2.16E-9,"rs1049281","rs2261033",367024,{"$f":" 0.129334","v":0.129334},-1.9300000000000001E-2,3.3999999999999998E-3,1.92E-8,-1.32347E-2,3.24136E-3,4.4444599999999998E-5,-1.43517E-2,3.2953499999999998E-3,1.32986E-5]
[null,"WCadjBMI"]
[null,3,"rs4378999",3.5799999999999998E-2,6.4999999999999997E-3,4.1199999999999998E-8,"rs4378999","rs4256170 ",16520,6.4000000000000001E-2,9.2799999999999994E-2,1.9199999999999998E-2,1.37E-6,8.0132400000000006E-2,1.9064600000000001E-2,2.6299999999999999E-5,8.57261E-2,1.9159900000000001E-2,7.6680599999999992E-6]
[null,9,"rs9409082",2.6800000000000001E-2,4.7000000000000002E-3,1.4899999999999999E-8,"rs9409082","rs902143",280862,5.0000000000000001E-3,1.6400000000000001E-2,3.5999999999999999E-3,6.4899999999999997E-6,1.53019E-2,3.5899999999999999E-3,2.0800000000000001E-5,1.60521E-2,3.5996600000000002E-3,8.2217999999999998E-6]
[null,20,"rs6012558",1.9699999999999999E-2,3.5000000000000001E-3,1.9099999999999999E-8,"rs6012558","rs4810880/\nrs237724*",100357,0.125,0.216,4.1999999999999997E-3,2.96E-7,0.14344000000000001,3.9975999999999996E-3,3.3300000000000002E-4,"-","-","-"]
[{"$nulls":8},406146,9.4E-2,2.4E-2,5.4999999999999997E-3,1.17E-5,"-","-","-",1.9780300000000001E-2,5.4489899999999999E-3,2.8333200000000002E-4]
["Independence of known loci",{"$nulls":12},"ARIC reference panel",null,null,"FHS reference panel"]
[null,"Chr","Tag SNP (TS) Before Conditioning",null,null,null,"Condition On",null,null,null,"Known SNP",null,null,"TS After Conditioning",null,null,"TS After Conditioning"]
[null,null,"Marker","β","SE","P","Known Marker","Trait","Distance","r2","β","SE","P","β","SE","P","β","SE","P"]
[null,"BMI"]
[null,2,"rs10929925",-0.02,3.3E-3,1.0629999999999999E-9,"rs10495537","Visceral fat",538962,3.3205000000000001E-7,1.9E-3,4.4000000000000003E-3,0.65910000000000002,-1.99756E-2,3.2997600000000001E-3,1.4160000000000001E-9,-1.99983E-2,3.3002399999999999E-3,1.3642200000000001E-9]
[{"$nulls":6},"rs7586540","coronary artery calcification",102806,2.03897E-2,1.8E-3,6.4999999999999997E-3,0.77890000000000004,-1.9873700000000001E-2,3.26859E-3,1.20024E-9,-1.99983E-2,3.3002399999999999E-3,1.3642200000000001E-9]
[null,"WHRadjBMI"]
[null,6,"rs1049281",-2.4799999999999999E-2,4.1999999999999997E-3,2.16E-9,"rs6457374","height",35694,{"$f":" 0.713296","v":0.71329600000000004},2.3199999999999998E-2,4.4000000000000003E-3,1.37E-7,-7.0092399999999999E-3,2.5014999999999998E-3,5.0784100000000002E-3,-8.0378099999999994E-3,2.7451899999999998E-3,3.4118899999999999E-3]
[{"$nulls":6},"rs2247056","height/triglycerides",28923,0.71419699999999997,-2.12E-2,4.0000000000000001E-3,1.4100000000000001E-7,-8.4499999999999992E-3,2.8509999999999998E-3,3.0300000000000001E-3,-9.3893499999999994E-3,3.0312199999999998E-3,1.9512799999999999E-3]
[{"$nulls":6},"rs2844479","height",336389,9.0098399999999995E-2,-1.6400000000000001E-2,3.8999999999999998E-3,2.94E-5,-1.9970000000000002E-2,4.0400000000000002E-3,7.7199999999999998E-7,-2.0591600000000002E-2,4.0795099999999997E-3,4.4746200000000001E-7]
[{"$nulls":6},"rs2857693","height",351817,0.11167199999999999,1.5299999999999999E-2,3.7000000000000002E-3,3.7599999999999999E-5,-1.9539999999999998E-2,4.0029999999999996E-3,1.0499999999999999E-6,-2.0150999999999999E-2,4.0472099999999999E-3,6.3923599999999999E-7]
[{"$nulls":6},"rs2256183","height",143962,0.2225,-1.12E-2,4.0000000000000001E-3,5.7580000000000001E-3,-1.9380000000000001E-2,3.728E-3,2.0100000000000001E-7,-1.9760699999999999E-2,3.7953599999999998E-3,1.9240300000000001E-7]
[{"$nulls":6},"rs7741091","HIPadjBMI",116064,0.14949200000000001,-0.01,3.7000000000000002E-3,6.5579999999999996E-3,-2.1049999999999999E-2,3.9649999999999998E-3,1.1000000000000001E-7,-2.1024500000000002E-2,3.9613799999999996E-3,1.11224E-7]
[{"$nulls":6},"rs13437082","height",117993,0.10173,9.7000000000000003E-3,4.1999999999999997E-3,2.2290000000000001E-2,-2.1999999999999999E-2,4.0220000000000004E-3,4.4999999999999999E-8,-2.18982E-2,4.0081600000000002E-3,4.6709099999999997E-8]
[{"$nulls":6},"rs1265097","height",130108,5.5663200000000003E-2,1.21E-2,7.3000000000000001E-3,9.7680000000000003E-2,-2.3441900000000002E-2,4.1197999999999999E-3,1.26989E-8,-2.3408399999999999E-2,4.1157199999999998E-3,1.28874E-8]
[{"$nulls":6},"rs12175489","VATadjBMI",141020,9.5643900000000007E-3,8.0999999999999996E-3,5.7999999999999996E-3,0.16719999999999999,-2.4240000000000001E-2,4.182E-3,6.72E-9,-2.4474699999999999E-2,4.1940199999999997E-3,5.35936E-9]
[{"$nulls":6},"rs879882","height",97115,9.3024599999999999E-2,-2.0999999999999999E-3,3.8999999999999998E-3,0.59279999999999999,-2.4168200000000001E-2,4.0332600000000003E-3,2.0700600000000002E-9,-2.4133000000000002E-2,4.0137000000000003E-3,1.8250399999999999E-9]
[null,"WCadjBMI"]
[null,2,"rs6743226",-2.24E-2,3.5000000000000001E-3,1.2E-10,"rs4344931","Height",418445,4.2999999999999997E-2,-7.9000000000000008E-3,4.4000000000000003E-3,6.9139999999999993E-2,-2.2457499999999998E-2,3.5001899999999998E-3,1.3982800000000001E-10,-2.25249E-2,3.49965E-3,1.22396E-10]
[{"$nulls":6},"rs6739772","HIPadjBMI",396261,4.2999999999999997E-2,-6.4999999999999997E-3,4.0000000000000001E-3,0.105,-2.2425500000000001E-2,3.5003E-3,1.48671E-10,-2.25122E-2,3.4996599999999999E-3,1.2537400000000001E-10]
[{"$nulls":6},"rs11687941","Height",45562,0.34100000000000003,1.9E-2,4.7999999999999996E-3,6.7399999999999998E-5,-6.1933099999999996E-3,3.9992700000000001E-3,0.121475,"-","-","-"]
[{"$nulls":6},"rs12694997","Height",26014,0.375,-1.6500000000000001E-2,4.1000000000000003E-3,6.9599999999999998E-5,-1.453E-2,2.9030599999999998E-3,5.5847799999999995E-7,-1.4361000000000001E-2,2.87434E-3,5.8442299999999997E-7]
[null,3,"rs4378999",-3.5799999999999998E-2,6.4999999999999997E-3,4.1199999999999998E-8,"rs13088462","Height",136933,0.43230499999999999,-3.4799999999999998E-2,8.3000000000000001E-3,2.58E-5,-2.2605500000000001E-2,5.6881299999999996E-3,7.0631199999999996E-5,-1.223E-2,1.2290000000000001E-2,0.31969999999999998]
[{"$nulls":6},"rs4256170","Height",16520,1.03903E-2,9.2799999999999994E-2,1.9199999999999998E-2,1.37E-6,-3.20369E-2,6.4539000000000003E-3,6.9070400000000002E-7,-3.3698600000000002E-2,6.4799999999999996E-3,2.0410000000000001E-7]
[null,4,"rs7697556*",2.0500000000000001E-2,3.5000000000000001E-3,5.21E-9,"rs9993613","HipadjBMI, Height",39299,1,2.0500000000000001E-2,4.0000000000000001E-3,3.0400000000000002E-7,"-","-","-",6.14885E-3,2.0998700000000002E-3,3.4093000000000001E-3]
[null,6,"rs615672ⱡ",-2.3400000000000001E-2,4.1999999999999997E-3,3.3099999999999999E-8,"rs2076529","WHRadjBMI",210216,0.17399999999999999,-1.3299999999999999E-2,3.5999999999999999E-3,2.0320000000000001E-4,-1.6865999999999999E-2,3.8098899999999998E-3,9.5596400000000002E-6,-1.6876800000000001E-2,3.81125E-3,9.5039000000000006E-6]
[{"$nulls":6},"rs7759742","WHRadjBMI",192435,0.124,1.32E-2,3.5999999999999999E-3,2.2560000000000001E-4,-1.7094100000000001E-2,3.8321700000000002E-3,8.1699100000000002E-6,-1.6486399999999998E-2,3.7534000000000001E-3,1.1210600000000001E-5]
[{"$nulls":6},"rs6457620","Height",89828,3.9E-2,4.1999999999999997E-3,4.0000000000000001E-3,0.29060000000000002,-2.2990500000000001E-2,4.1822600000000001E-3,3.8598300000000002E-8,-2.3143899999999999E-2,4.1933200000000004E-3,3.4048299999999998E-8]
[{"$nulls":6},"rs13196329","Visceral fat",248800,2E-3,2.1899999999999999E-2,1.67E-2,0.1893,-2.3499900000000001E-2,4.1997099999999997E-3,2.1986799999999999E-8,-2.3592399999999999E-2,4.1978400000000004E-3,1.9082600000000001E-8]
[null,7,"rs10269774",2.29E-2,4.1000000000000003E-3,2.8699999999999999E-8,"rs2888877","Height",25572,0.51400000000000001,2.0400000000000001E-2,5.1000000000000004E-3,6.1799999999999998E-5,1.2811899999999999E-2,3.2329199999999998E-3,7.4025900000000006E-5,1.2976100000000001E-2,3.2645299999999999E-3,7.0413299999999999E-5]
[{"$nulls":6},"rs42039","Height",9550,0.66300000000000003,2.4799999999999999E-2,4.7000000000000002E-3,1.01E-7,7.4723200000000002E-3,2.8745300000000001E-3,9.3361099999999999E-3,7.7586599999999997E-3,2.9287100000000002E-3,8.0688900000000004E-3]
[{"$nulls":6},"rs42235","HipadjBMI, Height",5896,0.85699999999999998,1.5800000000000002E-2,4.1000000000000003E-3,1.383E-4,9.1280700000000003E-3,2.01009E-3,5.5953399999999999E-6,9.0457000000000003E-3,1.9716E-3,4.4752300000000003E-6]
[{"$nulls":6},"rs2040494","Height",2933,0.55700000000000005,1.6299999999999999E-2,3.8999999999999998E-3,3.2700000000000002E-5,1.2045500000000001E-2,3.17294E-3,1.4684999999999999E-4,1.18937E-2,3.14285E-3,1.54098E-4]
[{"$nulls":6},"rs2282978","Height",10438,1,-1.77E-2,3.7000000000000002E-3,2.4399999999999999E-6,"-","-","-","-","-","-"]
[{"$nulls":6},"rs2188177","Height",405188,3.5000000000000003E-2,8.0999999999999996E-3,4.1999999999999997E-3,5.5070000000000001E-2,2.2851E-2,4.1002900000000004E-3,2.5034399999999999E-8,2.2828299999999999E-2,4.1002E-3,2.58259E-8]
[null,9,"rs9409082*",-2.6800000000000001E-2,4.7000000000000002E-3,1.4899999999999999E-8,"rs9408815","Lead SNP for Pjoint",10528,0.83399999999999996,2.5899999999999999E-2,4.5999999999999999E-3,2.2799999999999999E-8,"-","-","-",-5.1605399999999999E-3,2.7056599999999999E-3,5.6480000000000002E-2]
[{"$nulls":6},"rs902143","Height SNP",280862,5.0000000000000001E-3,1.6400000000000001E-2,3.5999999999999999E-3,6.4899999999999997E-6,-2.56545E-2,4.6937400000000001E-3,4.6112600000000002E-8,-2.6437100000000002E-2,4.6997999999999996E-3,1.8534700000000001E-8]
[{"$nulls":6},"rs10120372","Visceral adipose tissue/subcutaneous adipose tissu",460507,0.161,1.4E-2,8.6E-3,0.1021,-2.60612E-2,4.6785100000000003E-3,2.5414600000000001E-8,-2.5763600000000001E-2,4.6571599999999996E-3,3.1652300000000001E-8]
[null,20,"rs6012558",1.9699999999999999E-2,3.5000000000000001E-3,1.9099999999999999E-8,"rs17450430","Height SNP",240978,0.55500000000000005,-2.1399999999999999E-2,4.7000000000000002E-3,4.3000000000000003E-6,1.10283E-2,2.9366700000000002E-3,1.73086E-4,1.11647E-2,2.9558900000000001E-3,1.5866599999999999E-4]
[{"$nulls":6},"rs237743","Height SNP",371733,0.441,2.41E-2,4.7999999999999996E-3,5.7599999999999997E-7,1.1356099999999999E-2,3.0805099999999998E-3,2.27426E-4,1.1289799999999999E-2,3.0733599999999998E-3,2.3929600000000001E-4]
["ⱡ - ld calculated in HapMap r22"]

{"sheet":"ST 6. Conditional_App2","index":14,"n_rows":42,"n_cols":35,"rows_kept":42,"cut":false,"hidden":false,"merged":[[22,9,25,9],[22,2,25,2],[3,10,4,10],[6,1,6,34],[8,1,8,34],[10,1,10,34],[4,34,5,34],[3,12,5,12],[3,13,5,13],[3,11,5,11],[3,1,5,1],[4,2,5,2],[17,7,20,7],[17,8,20,8],[22,5,25,5],[22,6,25,6],[32,9,41,9],[21,1,21,34],[17,9,20,9],[31,1,31,34],[32,1,41,1],[32,2,41,2],[32,3,41,3],[32,4,41,4],[32,5,41,5],[32,6,41,6],[32,7,41,7],[32,8,41,8],[22,7,25,7],[22,8,25,8],[22,3,25,3],[22,4,25,4],[17,6,20,6],[14,2,15,2],[14,3,14,5],[14,6,14,8],[14,10,15,10],[14,9,15,9],[14,14,14,16],[13,12,15,12],[13,13,15,13],[13,28,13,34],[14,17,14,19],[14,34,15,34],[14,20,15,20],[14,21,14,23],[14,24,14,26],[14,27,15,27],[14,28,14,30],[14,31,14,33],[4,28,4,30],[4,31,4,33],[12,0,41,0],[12,21,12,26],[13,1,15,1],[13,2,13,9],[13,10,13,11],[13,14,13,20],[13,21,13,27],[16,1,16,34],[17,1,20,1],[17,2,20,2],[17,3,20,3],[17,4,20,4],[17,5,20,5],[14,11,15,11],[12,28,12,34],[0,0,1,34],[2,0,11,0],[2,21,2,27],[2,28,2,34],[3,2,3,9],[3,14,3,19],[3,21,3,27],[3,28,3,34],[4,3,4,5],[4,6,4,8],[4,14,4,16],[4,17,4,19],[4,21,4,23],[4,24,4,26],[4,27,5,27]]}
["Supplementary Table 6. Results for approximate conditional analyses to identify secondary signals and to determine independence from previously-identified anthropometric-associated SNPs for novel loci identified in Approach 2 (SNPjoint). *IndexSNP is also a previously identified height SNP."]
[]
["Secondary Signals",{"$nulls":20},"ARIC reference panel",{"$nulls":6},"FHS reference panel"]
[null,"Chr","Tag SNP (TS)",{"$nulls":7},"Condition on","Most Significant\nMarker After Conditioning","Distance","r2","Before Conditioning",{"$nulls":6},"After Conditioning",{"$nulls":6},"After Conditioning (FHS)"]
[null,null,"Marker","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint",{"$nulls":4},"SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint"]
[null,null,null,"β","SE","P","β","SE","P",null,"Lead SNP",null,null,null,"β","SE","P","β","SE","P",null,"β","SE","P","β","SE","P",null,"β","SE","P","β","SE","P"]
[null,"BMI"]
[null,3,"rs13069244",6.0999999999999999E-2,1.4200000000000001E-2,1.8E-5,3.0700000000000002E-2,7.7000000000000002E-3,6.5640000000000002E-5,3.4753825244312302E-8,"rs13069244","rs6443750",888510,1.06E-4,-6.0000000000000001E-3,0.01,0.54790000000000005,-1.78E-2,5.3E-3,8.1139999999999999E-4,4.6379999999999998E-2,"-","-","-","-","-","-","-",-5.7002199999999998E-3,9.9996700000000004E-3,0.56864999999999999,-1.7652600000000001E-2,5.3000599999999997E-3,8.6644900000000004E-4,3.315789E-3]
[null,"WHRadjBMI"]
[null,6,"rs1049281",-2.1499999999999998E-2,8.6E-3,1.2659999999999999E-2,-2.7099999999999999E-2,4.7999999999999996E-3,1.9799999999999999E-8,5.2599999999999996E-9,"rs1049281","rs9262169",508863,{"$f":" 0.00388707","v":3.8870699999999998E-3},1.4E-2,2.98E-2,0.63839999999999997,5.7000000000000002E-2,1.5900000000000001E-2,3.3799999999999998E-4,1.4501E-3,1.2186000000000001E-2,2.9790000000000001E-2,0.68200000000000005,5.4370300000000003E-2,1.58955E-2,6.2508599999999996E-4,2.6491171348340301E-3,-7.6188000000000002E-3,3.7653399999999998E-3,4.3031399999999997E-2,-9.7865299999999999E-3,2.75537E-3,3.8261099999999999E-4,2.35281E-4]
[null,"WCadjBMI"]
[null,9,"rs9408815",1.18E-2,9.7999999999999997E-3,0.2283,2.9899999999999999E-2,5.1000000000000004E-3,4.2199999999999999E-9,1.6700000000000001E-8,"rs9408815","rs902143",10528,0.83399999999999996,1.5599999999999999E-2,7.4000000000000003E-3,3.6540000000000003E-2,1.78E-2,4.1000000000000003E-3,1.1600000000000001E-5,8.7521411205359894E-6,1.5136999999999999E-2,7.3899999999999999E-3,4.0536999999999997E-2,1.6393999999999999E-2,4.0940000000000004E-3,6.2100000000000005E-5,4.0397356725868198E-5,1.52262E-2,7.39378E-3,3.9462900000000002E-2,1.6664399999999999E-2,4.0958699999999997E-3,4.72978E-5,3.0520640000000003E-5]
["Independence of known loci",{"$nulls":20},"ARIC reference panel",{"$nulls":6},"FHS reference panel"]
[null,"Chr","Tag SNP (TS)",{"$nulls":7},"Condition on",null,"Distance","r2","Known SNP",{"$nulls":6},"Tag SNP After Conditioning",{"$nulls":6},"Tag SNP After Conditioning"]
[null,null,"Marker","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint","Marker","Trait",null,null,"SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pjoint"]
[null,null,null,"β","SE","P","β","SE","P",{"$nulls":5},"β","SE","P","β","SE","P",null,"β","SE","P","β","SE","P",null,"β","SE","P","β","SE","P"]
[null,"BMI"]
[null,15,"rs12902602",4.7199999999999999E-2,7.0000000000000001E-3,1.7740000000000002E-11,-2.3E-3,3.8E-3,0.54710000000000003,1.1158516893702699E-10,"rs16969968","smoking",84476,0.40771800000000002,-3.8800000000000001E-2,7.6E-3,3.2800000000000003E-7,1.1999999999999999E-3,4.1999999999999997E-3,0.76649999999999996,2.0999999999999998E-6,2.6176999999999999E-2,5.6634800000000003E-3,3.7994800000000001E-6,-1.6680499999999999E-3,3.0899500000000002E-3,0.589314,6.6980360319015604E-5,2.6527800000000001E-2,5.7128400000000003E-3,3.4249800000000001E-6,-1.67859E-3,3.11604E-3,0.59009699999999998,1.7978638271518801E-5]
[{"$nulls":10},"rs6495309","smoking",52156,8.9366399999999999E-2,3.5299999999999998E-2,8.6E-3,4.0099999999999999E-5,-8.0000000000000002E-3,4.5999999999999999E-3,8.0530000000000004E-2,4.8399999999999997E-5,4.0045600000000001E-2,6.7825000000000003E-3,3.5423499999999999E-9,-6.6242700000000005E-4,3.68148E-3,0.85720399999999997,7.8687571833611302E-8,3.9787400000000001E-2,6.7660100000000003E-3,4.0908299999999996E-9,-6.0331999999999996E-4,3.6726200000000001E-3,0.86951500000000004,3.05614197790445E-8]
[{"$nulls":10},"rs899997","stroke",52177,0.20719299999999999,-2.2800000000000001E-2,8.0000000000000002E-3,4.4650000000000002E-3,2.2000000000000001E-3,4.1999999999999997E-3,0.61080000000000001,1.4999999999999999E-2,3.8263499999999999E-2,6.2616099999999999E-3,9.9126399999999998E-10,-1.3817199999999999E-3,3.3714499999999998E-3,0.68193099999999995,1.84440129935238E-9,3.9793799999999997E-2,6.5028600000000001E-3,9.3911999999999996E-10,-1.53896E-3,3.5112799999999999E-3,0.66117499999999996,6.7093471327314902E-9]
[{"$nulls":10},"rs3825807","CHD",121710,0.56434799999999996,3.7699999999999997E-2,7.4999999999999997E-3,5.6599999999999996E-7,1E-3,4.0000000000000001E-3,0.79669999999999996,3.1599999999999998E-6,2.3218099999999998E-2,5.1251600000000001E-3,5.8921099999999997E-6,-2.95641E-3,2.7470200000000002E-3,0.28182699999999999,1.5417613011934401E-5,2.3545199999999999E-2,5.1850000000000004E-3,5.5982299999999996E-6,-2.9474499999999999E-3,2.7807999999999999E-3,0.28917700000000002,1.8979222219243599E-5]
[null,"WCadjBMI"]
[null,2,"rs6743226",-1.8200000000000001E-2,7.3000000000000001E-3,1.2919999999999999E-2,-2.29E-2,3.8E-3,2.6139999999999999E-9,5.8107506595836201E-10,"rs4344931 \n(rs4311055, rsquare=1.00)","Height SNP",418445,4.2999999999999997E-2,-7.4999999999999997E-3,9.1999999999999998E-3,0.41449999999999998,-8.5000000000000006E-3,4.8999999999999998E-3,8.4400000000000003E-2,0.159315124678613,-1.8264099999999998E-2,7.3000000000000001E-3,1.2351900000000001E-2,-2.2968700000000002E-2,3.8001699999999999E-3,1.5023000000000001E-9,5.1054100308542803E-10,-1.8280399999999999E-2,7.2989800000000001E-3,1.2262E-2,null,"-",null,"-"]
[{"$nulls":10},"rs6739772 \n(rs3936203,rsquare = 0.9885)","Hipadj",396261,4.2999999999999997E-2,-4.1999999999999997E-3,9.4999999999999998E-3,0.65659999999999996,-8.6999999999999994E-3,5.3E-3,0.1011,0.23574486417596099,-1.8236499999999999E-2,7.2999600000000003E-3,1.24838E-2,-2.29654E-2,3.8001699999999999E-3,1.5104500000000001E-9,5.1808390130579604E-10,-1.8473799999999999E-2,7.29899E-3,1.13735E-2,null,"-",null,"-"]
[{"$nulls":10},"rs11687941","Height SNP",45562,0.34100000000000003,2.24E-2,9.9000000000000008E-3,2.375E-2,1.7500000000000002E-2,5.3E-3,8.6899999999999998E-4,3.3180371052610099E-4,-1.01426E-2,6.3728500000000002E-3,0.11149000000000001,-1.6936300000000001E-2,3.3437200000000001E-3,4.08165E-7,7.5681766673939902E-7,-9.9150699999999998E-3,6.3156100000000001E-3,0.11643100000000001,-1.6767899999999999E-2,3.3156700000000002E-3,4.2549599999999999E-7,8.1521419275315996E-7]
[{"$nulls":10},"rs12694997","Height SNP",26014,0.375,-2.5399999999999999E-2,8.6E-3,3.0590000000000001E-3,-1.38E-2,4.5999999999999999E-3,2.7789999999999998E-3,1.4173566034734501E-4,-6.3449200000000004E-3,6.0976800000000003E-3,0.29808600000000002,-1.6734800000000001E-2,3.1967800000000002E-3,1.6507799999999999E-7,6.5187115904959097E-7,-6.0904599999999998E-3,6.0400799999999998E-3,0.31329000000000001,-1.6602499999999999E-2,3.1679799999999999E-3,1.5996799999999999E-7,6.5347917563230303E-7]
[null,4,"rs7697556*",3.5999999999999999E-3,7.4000000000000003E-3,0.62549999999999994,2.5000000000000001E-2,4.0000000000000001E-3,7.3000000000000006E-11,2.9261316249199101E-9,"rs9993613","HipadjBMI, Height",39299,1,3.0000000000000001E-3,8.3999999999999995E-3,0.71950000000000003,2.53E-2,4.4000000000000003E-3,7.3010000000000003E-9,6.2068606315528506E-8,"-","-","-","-","-","-","-","-","-","-","-","-","-","-"]
[null,9,"rs9408815",1.18E-2,9.7999999999999997E-3,0.2283,0.03,5.0000000000000001E-3,4.2199999999999999E-9,7.3769446431850502E-9,"rs9409082","lead SNP for PadjSMK",10528,0.83399999999999996,-1.7399999999999999E-2,0.01,8.1269999999999995E-2,-2.9399999999999999E-2,5.3E-3,2.5629999999999999E-8,4.5783299236623802E-8,"-","-","-","-","-","-","-",-2.1583100000000001E-3,5.6289E-3,0.70139799999999997,8.1967800000000007E-3,3.09093E-3,8.0044399999999998E-3,2.7605275683934501E-2]
[{"$nulls":10},"rs9409082","Height SNP",10528,0.83399999999999996,-1.7399999999999999E-2,0.01,8.1269999999999995E-2,-2.9399999999999999E-2,5.3E-3,2.5629999999999999E-8,4.5783299236623802E-8,"-","-","-","-","-","-","-","-","-","-","-","-","-","-"]
[{"$nulls":10},"rs902143","Height SNP",291390,1.6E-2,1.5599999999999999E-2,7.4000000000000003E-3,3.6540000000000003E-2,1.78E-2,4.1000000000000003E-3,1.1569999999999999E-5,8.7521411205359894E-6,1.07268E-2,9.7868299999999998E-3,0.27306200000000003,2.87589E-2,4.9924699999999997E-3,8.3887399999999997E-9,3.4164492692973197E-8,1.0933399999999999E-2,9.7914400000000002E-3,0.26415499999999997,2.8997800000000001E-2,4.9953200000000001E-3,6.4365700000000002E-9,2.58125737268371E-8]
[{"$nulls":10},"rs10120372","VAT/SAT",449979,0.128,-4.1000000000000003E-3,1.83E-2,0.82369999999999999,1.5599999999999999E-2,9.5999999999999992E-3,0.10489999999999999,0.26043283208879098,1.19904E-2,9.76314E-3,0.21939700000000001,2.9280799999999999E-2,4.9810200000000001E-3,4.1408900000000002E-9,1.4744682267634E-8,1.2045999999999999E-2,9.7383799999999996E-3,0.21610299999999999,2.9071E-2,4.9678600000000002E-3,4.86241E-9,1.70535255248924E-8]
[null,"WHRadjBMI"]
[null,6,"rs1049281",-2.1499999999999998E-2,8.6E-3,1.2659999999999999E-2,-2.7099999999999999E-2,4.7999999999999996E-3,1.9799999999999999E-8,5.2599999999999996E-9,"rs1265097","Height",130108,5.5663200000000003E-2,4.4999999999999997E-3,1.47E-2,0.75949999999999995,1.3299999999999999E-2,8.6E-3,0.12130000000000001,0.28860259999999999,-2.0990000000000002E-2,8.4349999999999998E-3,1.285E-2,-2.5700000000000001E-2,4.7149999999999996E-3,4.9999999999999998E-8,1.5945847004964599E-8,-2.0973200000000001E-2,8.4267700000000001E-3,1.2814799999999999E-2,-2.5668E-2,4.7104699999999996E-3,5.0614900000000001E-8,1.61102946542074E-8]
[{"$nulls":10},"rs879882","Height",97115,9.3024599999999999E-2,8.0000000000000004E-4,4.0000000000000001E-3,0.84430000000000005,6.9999999999999999E-4,2.8999999999999998E-3,0.8125,0.95205550000000005,-2.1739999999999999E-2,8.5159999999999993E-3,1.0689000000000001E-2,-2.7310000000000001E-2,4.7200000000000002E-3,7.1799999999999996E-9,2.0585302753667698E-9,-2.1753499999999999E-2,8.5068100000000001E-3,1.05524E-2,-2.73236E-2,4.7104E-3,6.6037499999999997E-9,1.8769073216931501E-9]
[{"$nulls":10},"rs6457374","Height",35694,{"$f":" 0.713296","v":0.71329600000000004},4.7999999999999996E-3,4.4000000000000003E-3,0.26929999999999998,1.2699999999999999E-2,3.3E-3,1.3439999999999999E-4,3.3530000000000002E-4,-1.78E-2,7.9039999999999996E-3,2.4315E-2,-1.7330000000000002E-2,4.0740000000000004E-3,2.1100000000000001E-5,9.3453167364367995E-6,-1.8014200000000001E-2,7.9851000000000002E-3,2.4072400000000001E-2,-1.78922E-2,4.1618699999999998E-3,1.7152200000000002E-5,7.6122824086437896E-6]
[{"$nulls":10},"rs2247056","Height/triglycerides",28923,0.71419699999999997,-3.8999999999999998E-3,4.3E-3,0.36570000000000003,-1.29E-2,3.2000000000000002E-3,6.2399999999999999E-5,1.961E-4,-1.8499999999999999E-2,7.9389999999999999E-3,1.9795E-2,-1.7149999999999999E-2,4.1180000000000001E-3,3.1099999999999997E-5,1.1302290831783601E-5,-1.8671199999999999E-2,8.0152599999999997E-3,1.9834899999999999E-2,-1.7723900000000001E-2,4.1995299999999999E-3,2.4382299999999999E-5,8.9910886860778102E-6]
[{"$nulls":10},"rs13437082","Height",117993,0.10173,2.7000000000000001E-3,4.3E-3,0.52929999999999999,5.7999999999999996E-3,3.3E-3,7.3370000000000005E-2,0.17522760000000001,-2.0719999999999999E-2,8.5100000000000002E-3,1.4909E-2,-2.5420000000000002E-2,4.7039999999999998E-3,6.5499999999999998E-8,2.36467040910556E-8,-2.0690900000000002E-2,8.5036299999999999E-3,1.49666E-2,-2.5355900000000001E-2,4.6969300000000002E-3,6.7242000000000001E-8,2.4330222425696099E-8]
[{"$nulls":10},"rs2256183","Height",143962,0.2225,-9.9000000000000008E-3,8.3999999999999995E-3,0.23719999999999999,-1.0999999999999999E-2,4.7000000000000002E-3,1.8249999999999999E-2,3.22799E-2,-1.695E-2,7.6870000000000003E-3,2.7421999999999998E-2,-2.206E-2,4.2909999999999997E-3,2.7300000000000002E-7,1.59760864590523E-7,-1.7273199999999999E-2,7.8172899999999993E-3,2.7131700000000002E-2,-2.2418299999999999E-2,4.3639799999999999E-3,2.78981E-7,1.61912002760638E-7]
[{"$nulls":10},"rs2857693","Height",351817,0.11167199999999999,6.3E-3,3.8999999999999998E-3,0.1036,1.1900000000000001E-2,2.8999999999999998E-3,4.5099999999999998E-5,5.9799999999999997E-5,-1.933E-2,8.4950000000000008E-3,2.2882E-2,-2.3009999999999999E-2,4.6959999999999997E-3,9.6200000000000006E-7,4.6082225999562398E-7,-1.9580899999999998E-2,8.5182599999999997E-3,2.1522199999999998E-2,-2.3479799999999999E-2,4.7188500000000001E-3,6.4999700000000005E-7,2.99536526756347E-7]
[{"$nulls":10},"rs2844479","Height",336389,9.0098399999999995E-2,-4.7000000000000002E-3,4.1000000000000003E-3,0.25180000000000002,-1.11E-2,3.0000000000000001E-3,2.2800000000000001E-4,5.5199999999999997E-4,-2.0109999999999999E-2,8.515E-3,1.8171E-2,-2.383E-2,4.718E-3,4.4299999999999998E-7,1.78537421632606E-7,-2.0292999999999999E-2,8.5360100000000001E-3,1.7438100000000002E-2,-2.4247700000000001E-2,4.7383199999999999E-3,3.0982800000000001E-7,1.21960135743454E-7]
[{"$nulls":10},"rs12175489","VATadjBMI",141020,9.5643900000000007E-3,1E-3,5.3E-3,0.85429999999999995,-5.0000000000000001E-4,4.1999999999999997E-3,0.90990000000000004,0.97542099999999998,-2.1430000000000001E-2,8.5920000000000007E-3,1.264E-2,-2.71367E-2,4.7907000000000002E-3,1.4749500000000001E-8,4.8105362418195703E-9,-2.14564E-2,8.5976000000000004E-3,1.25734E-2,-2.71215E-2,4.7972199999999996E-3,1.5713400000000002E-8,5.0919828604061403E-9]
[{"$nulls":10},"rs7741091","HIPadjBMI",116064,0.14949200000000001,-2.5000000000000001E-3,4.0000000000000001E-3,0.53259999999999996,-5.8999999999999999E-3,3.0000000000000001E-3,4.7669999999999997E-2,0.1189322,-2.0559999999999998E-2,8.4690000000000008E-3,1.5183E-2,-2.4879999999999999E-2,4.666E-3,9.6999999999999995E-8,3.5132206240632398E-8,-2.0554699999999999E-2,8.4666700000000008E-3,1.51941E-2,-2.4863699999999999E-2,4.6639999999999997E-3,9.7687799999999997E-8,3.5398531063489498E-8]

{"sheet":"ST 7. Conditional_App3","index":15,"n_rows":17,"n_cols":36,"rows_kept":17,"cut":false,"hidden":false,"merged":[[23,9,24,9],[23,10,24,10],[25,9,26,9],[25,10,26,10],[13,7,16,7],[13,8,16,8],[13,9,16,9],[19,9,20,9],[19,10,20,10],[21,9,22,9],[21,10,22,10],[4,27,5,27],[13,5,16,5],[13,6,16,6],[10,14,10,16],[10,17,10,19],[10,20,11,20],[3,11,5,11],[10,2,11,2],[10,3,10,5],[10,6,10,8],[10,9,11,9],[10,10,11,10],[2,0,7,0],[2,21,2,26],[6,1,6,35],[8,0,16,0],[8,21,8,26],[9,1,11,1],[9,2,9,9],[9,10,9,11],[9,14,9,20],[9,21,9,27],[9,29,9,35],[10,32,10,34],[10,35,11,35],[12,1,12,35],[13,1,16,1],[13,2,16,2],[4,24,4,26],[3,1,5,1],[3,2,3,9],[3,10,4,10],[3,14,3,20],[4,2,5,2],[4,3,4,5],[4,6,4,8],[4,9,5,9],[4,14,4,16],[4,17,4,19],[0,0,1,35],[4,35,5,35],[4,20,5,20],[13,3,16,3],[13,4,16,4],[2,29,2,35],[3,21,3,27],[3,29,3,35],[4,32,4,34],[4,29,4,31],[10,29,10,31],[10,11,11,11],[10,21,10,23],[10,24,10,26],[10,27,11,27],[4,21,4,23]]}
["Supplementary Table 7. Results for approximate conditional analyses to identify secondary signals and to determine independence from previously-identified anthropometric-associated SNPs for novel loci identified in Approach 3 (SNPint)."]
[]
["Secondary Signals",{"$nulls":20},"ARIC reference panel",{"$nulls":7},"FHS reference panel"]
[null,"Chr","Tag SNP (TS)",{"$nulls":7},"Condition on","Most Significant\nMarker After Conditioning",null,null,"Before Conditioning",{"$nulls":6},"After Conditioning",{"$nulls":7},"After Conditioning (FHS)"]
[null,null,"Marker","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint",{"$nulls":4},"SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint","Most Significant","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint"]
[null,null,null,"β","SE","P","β","SE","P",null,"Lead SNP",null,"Distance","r2","β","SE","P","β","SE","P",null,"β","SE","P","β","SE","P",null,null,"β","SE","P","β","SE","P"]
[null,"BMI"]
[null,4,"rs336396",6.3E-2,1.15E-2,4.8189999999999997E-8,-5.8999999999999999E-3,6.1999999999999998E-3,0.34300000000000003,2.1322271483824598E-8,"rs336396","rs10857395",389724,1.0329600000000001E-3,3.4599999999999999E-2,1.2500000000000001E-2,5.7219999999999997E-3,1E-3,7.0000000000000001E-3,0.85299999999999998,1.2914200000000001E-2,3.6274599999999997E-2,1.24978E-2,3.7022499999999998E-3,8.3795699999999996E-4,6.9980900000000002E-3,0.90468899999999997,8.6425800000000004E-3,"rs10857395",3.6103700000000002E-2,1.2498499999999999E-2,3.8691300000000001E-3,"-","-","-","-"]
["Independence of known SNPs",{"$nulls":20},"ARIC reference panel"]
[null,"Chr","Tag SNP (TS)",{"$nulls":7},"Condition on",null,null,null,"Known SNP",{"$nulls":6},"Tag SNP After Conditioning",{"$nulls":7},"Tag SNP After Conditioning"]
[null,null,"Marker","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint","Marker","Trait",null,null,"SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint","SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint",null,"SMOKERS",null,null,"NON-SMOKERS",null,null,"Pint"]
[null,null,null,"β","SE","P","β","SE","P",null,null,null,"Distance","r2","β","SE","P","β","SE","P",null,"β","SE","P","β","SE","P",null,null,"β","SE","P","β","SE","P"]
[null,"BMI"]
[null,15,"rs12902602",4.7199999999999999E-2,7.0000000000000001E-3,1.7740000000000002E-11,-2.3E-3,3.8E-3,0.54710000000000003,4.0577765412530901E-11,"rs16969968","smoking",84476,0.40771800000000002,-3.8800000000000001E-2,7.6E-3,3.2800000000000003E-7,1.1999999999999999E-3,4.1999999999999997E-3,0.76649999999999996,9.7499999999999998E-7,2.6176999999999999E-2,5.6634800000000003E-3,3.7994800000000001E-6,-1.6680499999999999E-3,3.0899500000000002E-3,0.589314,4.2232200000000002E-6,"smoking",2.6527800000000001E-2,5.7128400000000003E-3,3.4249800000000001E-6,-1.67859E-3,3.11604E-3,0.59009699999999998,7.1799430000000002E-7]
[{"$nulls":10},"rs6495309","smoking",52156,8.9366399999999999E-2,3.5299999999999998E-2,8.6E-3,4.0099999999999999E-5,-8.0000000000000002E-3,4.5999999999999999E-3,8.0530000000000004E-2,2.43E-6,4.0045600000000001E-2,6.7825000000000003E-3,3.5423499999999999E-9,-6.6242700000000005E-4,3.68148E-3,0.85720399999999997,1.9554999999999999E-8,"smoking",3.9787400000000001E-2,6.7660100000000003E-3,4.0908299999999996E-9,-6.0331999999999996E-4,3.6726200000000001E-3,0.86951500000000004,9.5052240000000008E-10]
[{"$nulls":10},"rs899997","stroke",52177,0.20719299999999999,-2.2800000000000001E-2,8.0000000000000002E-3,4.4650000000000002E-3,2.2000000000000001E-3,4.1999999999999997E-3,0.61080000000000001,3.3271049999999999E-3,3.8263499999999999E-2,6.2616099999999999E-3,9.9126399999999998E-10,-1.3817199999999999E-3,3.3714499999999998E-3,0.68193099999999995,3.3414099999999999E-9,"stroke",3.9793799999999997E-2,6.5028600000000001E-3,9.3911999999999996E-10,-1.53896E-3,3.5112799999999999E-3,0.66117499999999996,1.6653679999999999E-10]
[{"$nulls":10},"rs3825807","CHD",121710,0.56434799999999996,3.7699999999999997E-2,7.4999999999999997E-3,5.6599999999999996E-7,1E-3,4.0000000000000001E-3,0.79669999999999996,4.5700000000000003E-6,2.3218099999999998E-2,5.1251600000000001E-3,5.8921099999999997E-6,-2.95641E-3,2.7470200000000002E-3,0.28182699999999999,2.0046499999999999E-6,"CHD",2.3545199999999999E-2,5.1850000000000004E-3,5.5982299999999996E-6,-2.9474499999999999E-3,2.7807999999999999E-3,0.28917700000000002,3.832459E-7]

{"sheet":"ST 8. Type I Error Rate","index":16,"n_rows":12,"n_cols":5,"rows_kept":12,"cut":false,"hidden":false,"merged":[[2,0,3,0],[2,1,3,1],[2,2,3,2],[2,3,3,3],[0,0,1,4]]}
["Supplementary Table 8. Simulation-based type 1 error rates. Shown are the simulation-based type 1 error rates of Approach 1 (adjusted effect), Approach 2 (joint effect), Approach 3 and 4 (interaction effects). For two different MAFs, the approaches were applied to 10,000 simulated stratum-specific effect sizes that were generated under stratum-specific null hypotheses of “no stratum-specific effects” and under the assumption of 50,000 smokers and 180,000 nonsmokers. The type 1 error rates shown reflect the proportion of nominally significant simulation results for the respective approach.  "]
[]
["Approach","MAF","#Variants tested","#Variants with P<0.05","Type 1 Error Rate"]
[{"$nulls":4}," [%]"]
["Approach 1",0.05,10000,515,5.15]
["(adjusted effect)",0.3,10000,486,4.8600000000000003]
["Approach 2",0.05,10000,492,4.92]
["(joint effect)",0.3,10000,487,4.87]
["Approach 3",0.05,10000,490,4.9000000000000004]
["(Interaction)",0.3,10000,514,5.14]
["Approach 4",0.05,515,27,5.24]
["(Interaction)",0.3,486,22,4.53]

{"sheet":"SD 8. Lookups in Previous GWAS","index":17,"n_rows":29,"n_cols":42,"rows_kept":29,"cut":false,"hidden":false,"merged":[[1,40,1,41],[1,36,1,37],[1,38,1,39],[1,18,1,20],[1,21,1,23],[1,24,1,26],[1,27,1,29],[1,30,1,32],[1,33,1,35]]}
["Supplementary Data 8. Look up of novel loci from the current analyses in previous GWAS of BMI, WC, WCadjBMI, WHR, WHRadjBMI, height and three smoking behavior traits (Ever/Never smoker, Current/Not Current Smoker, and Smoking Qantity)."]
[{"$nulls":18},"BMI",null,null,"WHRadjBMI",null,null,"WCadjBMI",null,null,"WHR",null,null,"WC ",null,null,"Height",null,null,"Ever vs. Never Smokers",null,"Current vs. Not Current Smokers",null,"Smoking Quantity"]
["Trait","Marker","Chr","Pos","Gene","Focus","Approach","Analysis\nLookup","Novel","A1","A2","N","BadjSMK","SEadjSMK","PadjSMK","Bint","Pint","Pjoint","Beta","P","N","Beta","P","N","Beta","P","N","Beta","P","N","Beta","P","N","Beta","P","N","Beta","P","Beta","P","Beta","P"]
["BMI","rs10929925",2,6155557,"SOX11","Primary","1-Adj, 2-Joint","AC","YES","C","A",225067,0.02,3.0000000000000001E-3,1.0999999999999999E-9,-2E-3,0.82,1.6000000000000001E-8,1.5699999999999999E-2,9.4339999999999996E-8,333579,2.8999999999999998E-3,0.39,218979,6.1999999999999998E-3,0.06,240253,1.0999999999999999E-2,5.1999999999999995E-4,221190,1.7999999999999999E-2,1.1999999999999999E-7,239009,-1.2999999999999999E-3,0.65,252923,4.9412299999999999E-2,1.4854600000000001E-2,-2.20121E-2,0.35254099999999999,1.87177E-2,0.11135299999999999]
["BMI","rs12629427",3,89145340,"EPHA3","Secondary","1-Adj:AW","EW","YES","C","T",137961,2.7E-2,5.0000000000000001E-3,4.8E-8,-3.0000000000000001E-3,0.8,1.9999999999999999E-7,1.29E-2,4.9569999999999996E-3,171694,2.5000000000000001E-3,0.64,116157,4.4000000000000003E-3,0.39,126878,1.0999999999999999E-2,2.9000000000000001E-2,117897,1.6E-2,1.6999999999999999E-3,127883,-8.0000000000000002E-3,2.1000000000000001E-2,250940,-3.0221700000000001E-2,0.192381,-3.7506299999999999E-2,0.17108100000000001,2.7787799999999998E-3,0.84146399999999999]
["BMI","rs12902602",15,78967401,"CHRNB4","Primary","3 - Int","AC","NO","A","G",240135,8.9999999999999993E-3,3.0000000000000001E-3,8.6E-3,0.05,4.1000000000000001E-11,1.0999999999999999E-10,7.4999999999999997E-3,1.3939999999999999E-2,338951,-1.8E-3,0.59,223972,-4.1000000000000003E-3,0.23,245249,2.5000000000000001E-3,0.46,226460,3.2000000000000002E-3,0.35,244283,-8.9999999999999998E-4,0.76,253020,3.9751300000000003E-2,5.0365199999999999E-2,3.40494E-2,0.15618099999999999,7.1470099999999995E-2,1.44629E-9]
["BMI","rs13069244",3,180441172,"CCDC39","Primary","2-Joint","AC","YES","A","G",233776,3.5000000000000003E-2,7.0000000000000001E-3,1.1999999999999999E-7,0.03,4.5999999999999999E-2,3.5000000000000002E-8,2.41E-2,4.7660000000000001E-5,335956,-6.8999999999999999E-3,0.31,222020,-3.0999999999999999E-3,0.64,243303,0.01,0.13,224192,2.7E-2,3.4999999999999997E-5,242023,-8.8000000000000005E-3,0.13,253031,2.7565699999999999E-2,0.47406199999999998,7.1073600000000001E-3,0.86953899999999995,-1.89205E-2,0.40380199999999999]
["BMI","rs2173039",3,89142175,"EPHA3","Secondary","1-Adj:EW","EW","YES","C","G",117942,3.1E-2,5.0000000000000001E-3,7.3E-9,-7.0000000000000001E-3,0.56999999999999995,6.5E-8,1.2999999999999999E-2,4.8580000000000003E-3,171692,2.3999999999999998E-3,0.64,116151,4.4000000000000003E-3,0.39,126878,1.0999999999999999E-2,0.03,117895,1.6E-2,1.6000000000000001E-3,127888,-7.9000000000000008E-3,2.1999999999999999E-2,250933,-2.7542500000000001E-2,0.23471600000000001,-3.45677E-2,0.207595,5.7952300000000002E-3,0.67493800000000004]
["BMI","rs2481665",1,62594677,"INADL","Secondary","1-Adj:EC","EC","YES","T","C",209453,1.9E-2,3.0000000000000001E-3,3.5000000000000002E-8,-7.0000000000000001E-3,0.4,6.7000000000000004E-8,1.5900000000000001E-2,1.903E-7,321790,2.5999999999999999E-3,0.46,209766,3.8999999999999998E-3,0.26,231028,0.01,3.0000000000000001E-3,212047,1.4999999999999999E-2,6.6000000000000003E-6,231935,-1.9E-3,0.52,252921,-2.1064699999999999E-2,0.28858899999999998,2.10149E-2,0.37511299999999997,-2.3900000000000001E-4,0.98363699999999998]
["BMI","rs336396",4,143062811," INPP4B","Primary","3 - Int","AC","YES","T","C",169646,7.0000000000000001E-3,6.0000000000000001E-3,0.23,6.9000000000000006E-2,2.0999999999999999E-8,1.9000000000000001E-7,9.4999999999999998E-3,7.8530000000000003E-2,230181,1.2999999999999999E-3,0.84,140451,-3.2000000000000002E-3,0.61,151171,6.7999999999999996E-3,0.28000000000000003,142338,8.3000000000000001E-3,0.2,151690,6.9999999999999999E-4,0.88,247778,2.4464900000000001E-2,0.32531399999999999,-2.70396E-2,0.35902600000000001,-2.9244200000000001E-2,4.98136E-2]
["BMI","rs6794880",3,84451512,"SRRM1P2","Primary","1-Adj","AC","YES","A","G",186968,2.8000000000000001E-2,5.0000000000000001E-3,4.3000000000000001E-8,-2E-3,0.85,1.7999999999999999E-6,1.61E-2,1.9599999999999999E-3,236170,-8.8999999999999999E-3,0.14000000000000001,142700,-1.2999999999999999E-2,3.2000000000000001E-2,152024,2E-3,0.74,144595,1.2E-2,5.8999999999999997E-2,153947,-1E-3,0.81,253174,2.3289600000000001E-2,0.40369100000000002,-1.0068499999999999E-2,0.75968100000000005,7.9218299999999995E-3,0.63769799999999999]
["WCadjBMI","rs10269774",7,92253972,"CDK6","Primary","1-Adj","AC","YES","A","G",157552,2.3E-2,4.0000000000000001E-3,2.9000000000000002E-8,1E-3,0.88,1.6E-7,-3.3999999999999998E-3,0.38329999999999997,236138,-4.4000000000000003E-3,0.32,142736,0.02,6.8000000000000001E-6,153456,-4.5999999999999999E-3,0.3,144574,8.8000000000000005E-3,5.0999999999999997E-2,153926,6.0999999999999999E-2,1.7999999999999998E-86,253197,2.50026E-2,0.22699900000000001,-1.49108E-2,0.54323699999999997,-1.1965699999999999E-2,0.32833499999999999]
["WCadjBMI","rs1545348",5,34718343,"RAI14","Secondary","1-Adj:EM","EM","YES","T","G",77677,3.4000000000000002E-2,6.0000000000000001E-3,1.7999999999999999E-8,1.4E-2,0.32,1.6999999999999999E-7,-3.5999999999999999E-3,0.44009999999999999,152815,1.4999999999999999E-2,8.8999999999999999E-3,93082,1.0999999999999999E-2,4.5999999999999999E-2,103263,1.0999999999999999E-2,4.2999999999999997E-2,94326,4.5999999999999999E-3,0.39,104335,-1.9E-3,0.57999999999999996,253031,-4.2013200000000001E-2,7.2722700000000001E-2,1.7454599999999999E-3,0.95151799999999997,3.0139599999999999E-2,2.4753500000000001E-2]
["WCadjBMI","rs17396340",1,10286176,"KIF1B","Primary","1-Adj, 2-Joint","AC","YES","A","G",206485,2.8000000000000001E-2,5.0000000000000001E-3,2.9999999999999997E-8,-1.9E-2,9.8000000000000004E-2,9.0999999999999996E-10,-5.3E-3,0.22620000000000001,339122,7.9000000000000008E-3,0.11,224326,0.02,4.8000000000000001E-5,245619,3.7000000000000002E-3,0.45,226555,5.7000000000000002E-3,0.24,244396,2.3E-2,2.6E-7,252105,7.5642600000000004E-2,1.49509E-2,1.38175E-2,0.697959,8.74722E-3,0.628108]
["WCadjBMI","rs4141488",16,9629067,"GRIN2A","Primary","3 - Int","AC","YES","T","C",153892,-3.0000000000000001E-3,4.0000000000000001E-3,0.441,5.2999999999999999E-2,2.6799999999999998E-8,4.9699999999999996E-7,6.1999999999999998E-3,0.1119,229967,-3.0999999999999999E-3,0.49,138296,2.5999999999999999E-3,0.56000000000000005,147618,6.9999999999999999E-4,0.88,140695,6.1000000000000004E-3,0.18,150046,-1E-3,0.75,246940,-1.02798E-2,0.61462799999999995,-6.2852999999999997E-3,0.79420900000000005,-7.0779399999999996E-3,0.55202899999999999]
["WCadjBMI","rs4378999",3,51208646,"DOCK3","Primary","1-Adj","AC","YES","T","A",156566,3.5999999999999997E-2,7.0000000000000001E-3,4.1000000000000003E-8,-1E-3,0.97,4.0999999999999999E-7,-1.66E-2,4.8999999999999998E-3,234838,0.02,3.0999999999999999E-3,142324,3.4000000000000002E-2,6.7000000000000004E-7,153043,9.1999999999999998E-3,0.18,144245,1.1000000000000001E-3,0.87,153597,3.4000000000000002E-2,5.9999999999999997E-13,250094,-6.2447299999999997E-2,5.5339899999999997E-2,3.5342999999999999E-2,0.35570499999999999,3.06336E-2,0.10509400000000001]
["WCadjBMI","rs6012558",20,47531286,"ARFGEF2","Primary","1-Adj","AC","YES","A","G",208004,0.02,4.0000000000000001E-3,1.9099999999999999E-8,8.0000000000000002E-3,0.33,1.2599999999999999E-7,-7.7999999999999996E-3,9.11E-3,338618,4.4000000000000003E-3,0.19,224021,1.0999999999999999E-2,1.4E-3,243901,1.1000000000000001E-3,0.75,226436,-6.9999999999999999E-4,0.83,244111,2.3E-2,1.1E-14,250902,-1.9613800000000001E-2,0.34448699999999999,-2.7174899999999998E-2,0.26572000000000001,1.0087E-3,0.93869100000000005]
["WCadjBMI","rs6076699",20,4566688,"PRNP","Secondary","3-Int:EW","EW","YES","A","G",76930,-3.4000000000000002E-2,1.6E-2,3.5000000000000003E-2,0.23899999999999999,1.4E-8,4.8E-8,-1.7299999999999999E-2,0.26129999999999998,123722,-2.3E-2,0.19,78256,-4.2000000000000003E-2,1.4E-2,84075,-2.1999999999999999E-2,0.21,79447,-2.8000000000000001E-2,0.11,84382,4.5999999999999999E-3,0.64,236684,-0.14168700000000001,2.9140599999999999E-2,-8.7040800000000002E-2,0.28107500000000002,-4.3319200000000002E-2,0.27316600000000002]
["WCadjBMI","rs6470765",8,130736697,"GSDMC","Primary","1-Adj","AC","YES","A","C",157450,2.5999999999999999E-2,5.0000000000000001E-3,4.8E-8,8.9999999999999993E-3,0.43,9.5000000000000001E-7,-5.1000000000000004E-3,0.2676,236055,-5.4999999999999997E-3,0.28999999999999998,142630,1.6E-2,2.0999999999999999E-3,153349,-7.3000000000000001E-3,0.17,144469,2.0999999999999999E-3,0.7,153821,4.7E-2,1.4E-38,253054,-8.3658099999999998E-4,0.97214299999999998,1.0486199999999999E-2,0.71480999999999995,1.4065599999999999E-2,0.32613799999999998]
["WCadjBMI","rs6743226",2,242236972,"HDLBP","Primary","1-Adj, 2-Joint","AC","YES","C","T",200666,2.1999999999999999E-2,4.0000000000000001E-3,1.2E-10,-5.0000000000000001E-3,0.55000000000000004,5.7999999999999996E-10,-1E-3,0.72640000000000005,339162,0.01,2.2000000000000001E-3,224364,1.4999999999999999E-2,1.3999999999999999E-6,245653,5.5999999999999999E-3,8.5000000000000006E-2,226541,5.1999999999999998E-3,0.11,244379,1.4E-2,3.4999999999999999E-6,253212,-3.3703299999999999E-2,9.4453400000000007E-2,1.1119499999999999E-2,0.63734900000000005,-3.3344E-3,0.78082300000000004]
["WCadjBMI","rs7697556",4,73515313,"ADAMTS3","Primary","1-Adj, 2-Joint","AC","YES","T","C",206017,2.1000000000000001E-2,4.0000000000000001E-3,5.2000000000000002E-9,-2.1999999999999999E-2,6.7000000000000002E-3,7.5999999999999996E-10,-5.0000000000000001E-3,8.9330000000000007E-2,338325,5.0000000000000001E-4,0.87,224091,1.6E-2,8.9999999999999996E-7,245383,-1.1000000000000001E-3,0.74,226232,6.7000000000000002E-3,4.2000000000000003E-2,244070,0.03,9.9999999999999996E-24,252350,1.6321199999999999E-3,0.93417099999999997,-7.9486599999999998E-3,0.73521800000000004,-7.2288500000000002E-3,0.53840699999999997]
["WCadjBMI","rs9408815",9,108890521,"TMEM38B","Primary","2-Joint","AC","YES","C","G",156427,2.5999999999999999E-2,5.0000000000000001E-3,2.3000000000000001E-8,-1.7999999999999999E-2,8.5000000000000006E-2,1.7E-8,-1.0500000000000001E-2,1.242E-2,235920,1.4999999999999999E-2,2.3999999999999998E-3,142168,2.3E-2,2.5000000000000002E-6,152888,7.7000000000000002E-3,0.11,144350,3.8E-3,0.45,153702,2.5999999999999999E-2,4.8999999999999999E-14,248585,6.5581199999999997E-3,0.77949800000000002,6.2937799999999997E-3,0.81903000000000004,-5.6947600000000001E-3,0.67001500000000003]
["WCadjBMI","rs9409082",9,108901049,"TMEM38B","Primary","1-Adj","AC","YES","C","T",157785,2.7E-2,5.0000000000000001E-3,1.4999999999999999E-8,-1.2E-2,0.27,4.6000000000000002E-8,-1.24E-2,3.9300000000000003E-3,235748,1.6E-2,1.2999999999999999E-3,142133,2.4E-2,9.5999999999999991E-7,151459,8.0000000000000002E-3,0.11,144496,3.3E-3,0.52,153848,2.8000000000000001E-2,8.7000000000000002E-15,252750,1.08278E-2,0.64534100000000005,1.9059799999999998E-2,0.487479,-5.9529200000000004E-3,0.65889699999999995]
["WHRadjBMI","rs1049281",6,31236567,"HLA-C","Primary","1-Adj, 2-Joint","AC","YES","C","T",149285,2.5000000000000001E-2,4.0000000000000001E-3,2.1999999999999998E-9,-6.0000000000000001E-3,0.56000000000000005,5.3000000000000003E-9,-7.1000000000000004E-3,4.7820000000000001E-2,275574,1.7999999999999999E-2,1.1E-5,176499,4.4999999999999997E-3,0.26,191086,1.2999999999999999E-2,1.5E-3,178527,-2.8E-3,0.48,189706,-3.4000000000000002E-2,8.9000000000000006E-27,245614,-1.0484E-2,0.61707800000000002,2.0539100000000001E-2,0.407163,-8.1291699999999998E-3,0.50888299999999997]
["WHRadjBMI","rs17065323",13,44627788,"SMIM2","Secondary","1-Adj:EC","EC","YES","T","C",69968,-0.18099999999999999,3.2000000000000001E-2,9.1999999999999997E-9,0.38300000000000001,1.4E-3,3.9E-10,3.0000000000000001E-3,0.91979999999999995,180159,-4.8000000000000001E-2,0.12,120802,-4.8000000000000001E-2,0.12,135293,-3.2000000000000001E-2,0.28999999999999998,118736,-3.2000000000000001E-2,0.31,132379,-1.2999999999999999E-2,0.67,136736,-2.98345E-2,0.81701500000000005,4.6450699999999998E-2,0.74573,1.8491299999999999E-2,0.80193899999999996]
["WHRadjBMI","rs1856293",6,133480940,"EYA4","Secondary","2-Joint:EC","EC","YES","A","C",127431,-1.9E-2,4.0000000000000001E-3,6.4999999999999996E-6,3.4000000000000002E-2,5.4000000000000001E-4,4.6999999999999997E-8,-2.2000000000000001E-3,0.55210000000000004,233912,-1.4E-2,1.1999999999999999E-3,142728,0,1,153447,-1.2E-2,4.3E-3,144563,-1.1999999999999999E-3,0.78,153915,1.0999999999999999E-2,2.9999999999999997E-4,253117,-4.8732200000000003E-2,1.5823400000000001E-2,-7.26437E-3,0.75956599999999996,1.9642700000000002E-3,0.86779200000000001]
["WHRadjBMI","rs2001945",8,126477978,"TRIB1","Secondary","1-Adj:AW","EW","YES","G","C",103446,2.5000000000000001E-2,5.0000000000000001E-3,4.6999999999999997E-8,-4.0000000000000001E-3,0.59,1.2999999999999999E-4,-6.1000000000000004E-3,0.1153,171910,1.6E-2,2.9E-4,116678,1.8E-3,0.68,127398,1.2999999999999999E-2,3.8999999999999998E-3,117970,-1.9E-3,0.66,127956,-1.0999999999999999E-2,2.5000000000000001E-4,252645,2.26232E-2,0.24759999999999999,1.07952E-2,0.64361699999999999,1.33513E-2,0.25013299999999999]
["WHRadjBMI","rs589428",6,31848220,"EHMT2","Secondary","1-Adj:EC","EC","YES","G","T",162918,2.1999999999999999E-2,4.0000000000000001E-3,2.7999999999999999E-8,-5.0000000000000001E-3,0.35,6.9999999999999999E-4,-8.8000000000000005E-3,7.9159999999999994E-3,314617,1.4999999999999999E-2,7.2000000000000002E-5,202669,4.7000000000000002E-3,0.2,223893,8.5000000000000006E-3,1.9E-2,204877,-5.3E-3,0.15,224745,-2.9000000000000001E-2,4.7000000000000003E-21,251566,3.1766200000000001E-2,0.135772,1.0367900000000001E-3,0.96683799999999998,1.3871400000000001E-2,0.26385399999999998]
["WHRadjBMI","rs670752",3,107312980,"BBX","Secondary","1-Adj:AW","EW","YES","A","G",107569,2.7E-2,5.0000000000000001E-3,4.9000000000000002E-8,3.0000000000000001E-3,0.68,7.7999999999999996E-3,-2.3E-3,0.59619999999999995,171843,1.4E-2,5.7000000000000002E-3,116567,1.2999999999999999E-2,8.0000000000000002E-3,127295,9.2999999999999992E-3,5.1999999999999998E-2,117944,3.0999999999999999E-3,0.51,127937,2.9999999999999997E-4,0.92,252979,-2.70572E-3,0.89936499999999997,2.5228199999999999E-2,0.32059700000000002,2.7470799999999998E-3,0.82736600000000005]

{"sheet":"ST 9. VarianceExplained","index":18,"n_rows":47,"n_cols":15,"rows_kept":47,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 9. Variance explained in smoking strata for significant variants from Approach 1 (SNPadjSMK) at varying thresholds."]
["Trait","Number of SNPs ","Approach 2 PJoint threshold ","Variance smokers ","Variance error Smokers","Variance nonsmokers","Variance error Nonsmokers","Difference in Variance (Smokers-Nonsmokers)","Error for difference in Variance","Pvalue"]
["BMI",44,1E-8,1.8401803496334398E-2,1.25303832472E-3,1.27864234203605E-2,5.3854298915145696E-4,5.6153800759738796E-3,1.3636838999733401E-3,3.8250336715141197E-5]
["BMI",50,3.1622776601683799E-8,1.9068888555858698E-2,1.2790167895475699E-3,1.3676321517321699E-2,5.5736475101803397E-4,5.3925670385370304E-3,1.39499078224197E-3,1.10786920892917E-4]
["BMI",65,9.9999999999999995E-8,2.0340521886701601E-2,1.3261390035562599E-3,1.5829046867362601E-2,6.0118624754759904E-4,4.5114750193389801E-3,1.4558293689199201E-3,1.9423814313887899E-3]
["BMI",84,3.1622776601683802E-7,2.37400242705425E-2,1.4461652676552399E-3,1.8093183612725099E-2,6.4699398310301295E-4,5.6468406578173598E-3,1.5840423557086599E-3,3.64093021960706E-4]
["BMI",105,9.9999999999999995E-7,2.61641355454388E-2,1.53253858827487E-3,2.0676249786059E-2,6.9868141804505098E-4,5.4878857593797497E-3,1.68399847603816E-3,1.1186776425472699E-3,{"$nulls":4}," "]
["BMI",132,3.16227766016838E-6,3.0110599337440001E-2,1.66376774679131E-3,2.3429342181127199E-2,7.4953107787753505E-4,6.6812571563128597E-3,1.8244681890127901E-3,2.5022459407948001E-4]
["BMI",190,1.0000000000000001E-5,3.79697627813608E-2,1.89332498917834E-3,2.88472289621272E-2,8.4217067536153595E-4,9.1225338192335893E-3,2.0717472540115701E-3,1.0661440380301E-5]
["BMI",271,3.1622776601683802E-5,4.67879433992857E-2,2.1373643720733401E-3,3.5676473353563803E-2,9.4717097796045003E-4,1.11114700457219E-2,2.33728244200428E-3,1.9941865752351101E-6]
["BMI",436,1E-4,6.2373663647215298E-2,2.5261599697743902E-3,4.8064404099268099E-2,1.11727110062101E-3,1.4309259547947199E-2,2.7614390142278E-3,2.1973990405088699E-7]
["BMI",708,3.1622776601683799E-4,8.6330327252839498E-2,3.0417610390705298E-3,6.5894432367146302E-2,1.33078447047384E-3,2.0435894885693199E-2,3.3190359463863102E-3,7.4052634597211101E-10]
["BMI",1147,1E-3,0.115914973279601,3.6053821415971601E-3,9.0365526378069397E-2,1.5822289948320301E-3,2.5549446901531499E-2,3.9357379318955598E-3,8.4899349299097605E-11]
["BMI",1841,3.1622776601683798E-3,0.15124428194448,4.2216467420707598E-3,0.122354704726244,1.8709231597463501E-3,2.8889577218236699E-2,4.6155011963669402E-3,3.8683259047892802E-10]
["BMI",2687,0.01,0.18356014961602099,4.7495959847331497E-3,0.152436689911427,2.1109479845125199E-3,3.1123459704594E-2,5.1948502239611699E-3,2.0828027291747999E-9]
["BMI",3407,3.1622776601683798E-2,0.20449349195344901,5.10314056572645E-3,0.17062092765195599,2.2501289854745502E-3,3.3872564301492901E-2,5.5740786452376798E-3,1.2260408266230501E-9]
["BMI",3793,0.1,0.21136628452065001,5.2365674244240499E-3,0.17641670891544101,2.2968726971995999E-3,3.4949575605208998E-2,5.7148858787889802E-3,9.6234508897291003E-10]
["WCadjBMI",50,1E-8,1.43E-2,1.1999999999999999E-3,1.3299999999999999E-2,5.9999999999999995E-4,8.9999999999999998E-4,1.4E-3,0.498]
["WCadjBMI",59,3.1599999999999998E-8,1.5299999999999999E-2,1.2999999999999999E-3,1.5100000000000001E-2,5.9999999999999995E-4,2.0000000000000001E-4,1.4E-3,0.90500000000000003]
["WCadjBMI",69,9.9999999999999995E-8,1.7000000000000001E-2,1.2999999999999999E-3,1.67E-2,6.9999999999999999E-4,2.9999999999999997E-4,1.5E-3,0.83799999999999997]
["WCadjBMI",77,3.1600000000000002E-7,1.8499999999999999E-2,1.4E-3,1.77E-2,6.9999999999999999E-4,8.0000000000000004E-4,1.6000000000000001E-3,0.61399999999999999]
["WCadjBMI",94,9.9999999999999995E-7,2.0899999999999998E-2,1.5E-3,2.01E-2,6.9999999999999999E-4,8.0000000000000004E-4,1.6999999999999999E-3,0.65100000000000002]
["WCadjBMI",115,3.1599999999999998E-6,2.3E-2,1.6000000000000001E-3,2.3E-2,8.0000000000000004E-4,0,1.8E-3,0.98699999999999999]
["WCadjBMI",148,1.0000000000000001E-5,2.6700000000000002E-2,1.6999999999999999E-3,2.6800000000000001E-2,8.9999999999999998E-4,-1E-4,1.9E-3,0.95899999999999996]
["WCadjBMI",206,3.1600000000000002E-5,3.0200000000000001E-2,1.9E-3,3.3500000000000002E-2,1E-3,-3.3E-3,2.0999999999999999E-3,0.11700000000000001]
["WCadjBMI",322,1E-4,3.7999999999999999E-2,2.2000000000000001E-3,4.4900000000000002E-2,1.1999999999999999E-3,-6.8999999999999999E-3,2.5000000000000001E-3,4.9100000000000003E-3]
["WCadjBMI",538,3.1599999999999998E-4,5.0500000000000003E-2,2.5999999999999999E-3,6.3399999999999998E-2,1.4E-3,-1.29E-2,2.8999999999999998E-3,1.19E-5]
["WCadjBMI",926,1E-3,6.4899999999999999E-2,3.0000000000000001E-3,9.1999999999999998E-2,1.6999999999999999E-3,-2.7099999999999999E-2,3.5000000000000001E-3,8.5099999999999998E-15]
["WCadjBMI",1603,3.16E-3,8.6199999999999999E-2,3.5999999999999999E-3,0.13170000000000001,2.0999999999999999E-3,-4.5499999999999999E-2,4.1999999999999997E-3,3.8100000000000003E-27]
["WCadjBMI",2505,0.01,0.10589999999999999,4.1999999999999997E-3,0.17249999999999999,2.5000000000000001E-3,-6.6500000000000004E-2,4.8999999999999998E-3,2.0399999999999999E-42]
["WCadjBMI",3303,3.1600000000000003E-2,0.1129,4.4999999999999997E-3,0.1991,2.7000000000000001E-3,-8.6199999999999999E-2,5.1999999999999998E-3,1.4000000000000001E-60]
["WCadjBMI",3781,0.1,0.1174,4.7000000000000002E-3,0.2079,2.7000000000000001E-3,-9.0499999999999997E-2,5.4000000000000003E-3,4.1100000000000003E-62]
["WHRadjBMI",50,1E-8,1.5447634779295E-3,4.8746750933657102E-4,2.82466933637366E-3,3.0153584053154998E-4,-1.27990585844416E-3,5.7317219840357595E-4,2.5547524723796199E-2]
["WHRadjBMI",59,3.1622776601683799E-8,2.1266361896216902E-3,5.5797912235269905E-4,3.5637552976744099E-3,3.4103268722255697E-4,-1.4371191080527199E-3,6.5392002793058298E-4,2.79705937747089E-2]
["WHRadjBMI",69,9.9999999999999995E-8,2.4250907139498098E-3,5.9886230240874705E-4,4.1440087086950404E-3,3.7105456159983402E-4,-1.7189179947452299E-3,7.04468979923194E-4,1.46864722061078E-2]
["WHRadjBMI",77,3.1622776601683802E-7,2.6608943637277901E-3,6.2642211731945901E-4,4.3481908140578299E-3,3.7996453456970799E-4,-1.68729645033004E-3,7.32619985790205E-4,2.12732663750172E-2]
["WHRadjBMI",94,9.9999999999999995E-7,2.6919044267078901E-3,6.5495399686553999E-4,5.0014726901725899E-3,4.1223491627981101E-4,-2.3095682634646998E-3,7.7385246609296902E-4,2.8403550866357898E-3]
["WHRadjBMI",115,3.16227766016838E-6,2.6811609196698699E-3,6.8749867196335197E-4,6.0119734095837197E-3,4.60491185872977E-4,-3.3308124899138502E-3,8.2742851343416395E-4,5.6854669827038902E-5]
["WHRadjBMI",148,1.0000000000000001E-5,2.9366786711952099E-3,7.5003571560618805E-4,6.9734617690525502E-3,5.0171292017101E-4,-4.0367830978573398E-3,9.0231950787981996E-4,7.6847165471912696E-6]
["WHRadjBMI",206,3.1622776601683802E-5,2.9440108338840798E-3,8.34602269518084E-4,9.4832475179263305E-3,5.9617129497063998E-4,-6.5392366840422598E-3,1.0255961685518801E-3,1.8173185330138401E-10]
["WHRadjBMI",321,1E-4,3.4216095636796099E-3,1.0059522046862899E-3,1.4525293730907499E-2,7.4935082900558496E-4,-1.1103684167227901E-2,1.25428021371061E-3,8.54773056507157E-19]
["WHRadjBMI",537,3.1622776601683799E-4,4.4391073686725303E-3,1.2782870316087199E-3,2.3014690582487202E-2,9.5969057883715802E-4,-1.8575583213814702E-2,1.59828350914989E-3,3.1781512340788398E-31]
["WHRadjBMI",923,1E-3,4.6692651748813903E-3,1.6207550827525201E-3,3.6270687295859201E-2,1.2354590723025901E-3,-3.1601422120977898E-2,2.0376794202986402E-3,3.03731092385631E-54]
["WHRadjBMI",1598,3.1622776601683798E-3,5.2886954610652298E-3,2.1137749554617398E-3,5.4072320397188497E-2,1.53614354241861E-3,-4.8783624936123302E-2,2.6125771722828898E-3,8.27159835176129E-78]
["WHRadjBMI",2496,0.01,6.48615139480731E-3,2.6469082287514899E-3,7.2068418570863005E-2,1.8047029593810601E-3,-6.5582267176055697E-2,3.2029780166654099E-3,3.56781465355006E-93]
["WHRadjBMI",3293,3.1622776601683798E-2,6.8288448700107897E-3,3.0448549616639499E-3,8.3593364489391697E-2,1.9685940649856802E-3,-7.6764519619380897E-2,3.6250258790761001E-3,1.58070393607212E-99]
["WHRadjBMI",3773,0.1,6.5419002930494101E-3,3.2504916586212902E-3,8.8189592470624106E-2,2.0382537816254001E-3,-8.1647692177574602E-2,3.8358203211838401E-3,1.5439712455639201E-100]

{"sheet":"ST 10. eQTL_Public Databases","index":19,"n_rows":189,"n_cols":11,"rows_kept":189,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 10. Association of cis-acting expression quantitative trait loci (cis-eQTLs) for novel loci using publicly available databases."]
["Trait","IndexSNP","Proxy SNP","r2 CEU\nIndexSNP vs ProxySNP","P ProxySNP","Tissue","Transcript","Best\nE-SNP","Best\nE-SNP P","r2 CEU\nIndexSNP vs BestESNP","PMID"]
["BMI","rs12629427","rs9860797",0.90542800000000001,2.23E-5,"Cerebellum (all samples)","EPHA3","rs9860797",2.23E-5,0.86499999999999999,23622250]
["BMI","rs12629427","rs9860797",0.90542800000000001,3.7100000000000001E-5,"Prefrontal cortex (Alzheimer's)","EPHA3","rs9860797",3.7100000000000001E-5,0.86499999999999999,23622250]
["BMI","rs13069244","rs13069244","IndexSNP",2.09E-5,"Peripheral blood mononuclear cells","TTC14","rs1921678",6.4600000000000005E-109,"unavailable",26019233]
["BMI","rs2481665","rs2481665","IndexSNP",7.3100000000000003E-6,"Prefrontal cortex (Huntington's)","INADL","rs2481665",7.3100000000000003E-6,"SameSNP",23622250]
["WCadjBMI","rs10269774","rs2282978",0.92062699999999997,2.616E-5,"Cerebellum (normal samples)","CDK6","rs2282978",2.616E-5,1,23622250]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",1.8500000000000001E-15,"B-lymphoblastoid cell lines (collected at age 8)","ENSG00000054523","rs17396340",1.8500000000000001E-15,"SameSNP",25010687]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",8.2700000000000006E-118,"Peripheral blood mononuclear cells","KIF1B","rs17396340",8.2700000000000006E-118,"SameSNP",26019233]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",1.2100000000000001E-7,"Peripheral blood mononuclear cells","KIF1B","rs17396340",8.2700000000000006E-118,"SameSNP",26019233]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",3.8500000000000004E-6,"Whole blood (PAX) in individuals without asthma","KIF1B","rs17396340",3.8500000000000004E-6,"SameSNP",25816334]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",9.8100000000000005E-198,"Whole blood (CHARGE)","KIF1B","rs12139158",9.8100000000000005E-198,1,24013639]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",2.6400000000000001E-11,"Whole blood (CHARGE)","KIF1B","rs12139158",9.8100000000000005E-198,1,24013639]
["WCadjBMI","rs17396340","rs17396340","IndexSNP",9.0100000000000005E-29,"LCL (MuTHER)","KIF1B","rs6693965",7.6600000000000001E-29,0.92,22941192]
["WCadjBMI","rs17396340","rs17397129",1,4.6399999999999999E-113,"Peripheral blood mononuclear cells","KIF1B","rs17396340",8.2700000000000006E-118,"SameSNP",26019233]
["WCadjBMI","rs17396340","rs17397129",1,3.3200000000000001E-7,"Peripheral blood mononuclear cells","KIF1B","rs17396340",8.2700000000000006E-118,"SameSNP",26019233]
["WCadjBMI","rs17396340","rs17397129",1,9.8100000000000005E-198,"Whole blood (CHARGE)","KIF1B","rs12139158",9.8100000000000005E-198,1,24013639]
["WCadjBMI","rs17396340","rs17397129",1,6.9899999999999996E-10,"Whole blood (CHARGE)","KIF1B","rs12139158",9.8100000000000005E-198,1,24013639]
["WCadjBMI","rs17396340","rs17397129",1,1.08E-26,"LCL (MuTHER)","KIF1B","rs6693965",7.6600000000000001E-29,0.92,22941192]
["WCadjBMI","rs4378999","rs10212250",0.99401799999999996,1.622065E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs10212250",0.99401799999999996,5.4199999999999999E-14,"CD14+ monocytes (24h LPS stimulated)","MAPKAPK3","rs7614881",9.3900000000000001E-18,0.8,24604202]
["WCadjBMI","rs4378999","rs10212250",0.99401799999999996,1.66312E-4,"CD14+ monocytes (2h LPS stimulated)","MAPKAPK3","rs7614881",7.3699999999999997E-6,0.8,24604202]
["WCadjBMI","rs4378999","rs10212250",0.99401799999999996,2.2593E-4,"CD14+ monocytes (2h LPS stimulated)","TEX264","rs1055429",8.0200000000000001E-7,0.8,24604202]
["WCadjBMI","rs4378999","rs10212250",0.99401799999999996,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs11130274",0.98805900000000002,2.39E-6,"Liver(Greenawalt)","AK093691","rs11130274",2.39E-6,1,21602305]
["WCadjBMI","rs4378999","rs11130274",0.98805900000000002,3.18091E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs11130274",0.98805900000000002,9.2799999999999997E-8,"Prefrontal cortex (all samples)","C3orf18","rs11130274",9.2799999999999997E-8,1,23622250]
["WCadjBMI","rs4378999","rs11130274",0.98805900000000002,1.13E-25,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs11130274",0.98805900000000002,3.6900000000000002E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs11130282",0.99401799999999996,1.6214300000000001E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs11130282",0.99401799999999996,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs11919932",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs13324500",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs1383252",0.99401799999999996,1.6280209999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs1383252",0.99401799999999996,1.03E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs1480357",0.96481899999999998,1.810503E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs1480357",0.96481899999999998,1.29E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs1480358",0.99401799999999996,1.810524E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs1480358",0.99401799999999996,8.5300000000000005E-11,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs1480358",0.99401799999999996,1.3E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs1480363",0.99401799999999996,1.628238E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs1480363",0.99401799999999996,1.03E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs1552072",0.99401799999999996,1.809773E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs1552072",0.99401799999999996,1.3E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs2061951",0.99401799999999996,1.6280960000000001E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs2061951",0.99401799999999996,1.03E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs2355941",0.99401799999999996,1.6280979999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs2355941",0.99401799999999996,1.03E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4244696",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4244697",1,9.2095199999999995E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4244697",1,1.7600000000000001E-25,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4244704",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4263323",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4286453",0.90468400000000004,1.8899999999999998E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4301044",0.98805900000000002,1.6262609999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4301044",0.98805900000000002,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4328835",0.98805900000000002,7.9600000000000004E-26,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4328835",0.98805900000000002,4.0000000000000003E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs4367101",0.99401799999999996,1.6207870000000001E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4367101",0.99401799999999996,1.0100000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4373098",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4377512",0.90468400000000004,2.5400000000000001E-11,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs4377512",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4378999","IndexSNP",9.1460900000000004E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4378999","IndexSNP",1.72E-25,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4446244",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4453876",0.99401799999999996,1.6212830000000001E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4453876",0.99401799999999996,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4478114",0.90468400000000004,4.7599999999999999E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs4478114",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4505743",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4511933",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4528983",1,1.6202619999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4528983",1,1.0100000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4530566",0.90468400000000004,6.43E-11,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs4530566",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4532165",0.98805900000000002,3.1963800000000002E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4532165",0.98805900000000002,1.05E-25,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4532165",0.98805900000000002,3.8899999999999997E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs4555554",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4568177",0.99401799999999996,1.621482E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4568177",0.99401799999999996,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4582086",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4589968",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4615113",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4927978",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4927983",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4974095",0.98232399999999997,1.8094299999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4974095",0.98232399999999997,1.3E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs4974109",0.97632099999999999,1.809976E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs4974109",0.97632099999999999,1.3E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6445455",0.98805900000000002,5.4198099999999997E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs6445455",0.98805900000000002,4.7900000000000002E-26,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6445455",0.98805900000000002,4.1499999999999999E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs6445551",0.99401799999999996,1.6277119999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs6445551",0.99401799999999996,1.03E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6445600",0.90468400000000004,2.9099999999999999E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs6445600",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6445717",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6445750",0.90468400000000004,4.6800000000000003E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs6445750",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6445779",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6446011",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6446118",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6446167",0.90468400000000004,5.8599999999999997E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs6446167",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6768601",0.90468400000000004,3.8399999999999998E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs6768601",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6772664",1,1.618614E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs6772664",1,1.0100000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6777719",0.98805900000000002,8.5399999999999996E-6,"Lung","TEX264","rs6777719",8.5399999999999996E-6,1,23209423]
["WCadjBMI","rs4378999","rs6777719",0.98805900000000002,5.4571299999999997E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs6777719",0.98805900000000002,4.8400000000000001E-26,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6777719",0.98805900000000002,4.1699999999999997E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs6779658",1,1.509278E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs6779658",1,4.1199999999999998E-25,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6793613",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs6809080",0.99401799999999996,1.627014E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs6809080",0.99401799999999996,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7611873",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7614171",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7615291",0.90468400000000004,3.1899999999999999E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs7615291",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7619584",0.99401799999999996,1.623467E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs7619584",0.99401799999999996,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7628533",0.99401799999999996,5.4199999999999999E-14,"CD14+ monocytes (24h LPS stimulated)","MAPKAPK3","rs7614881",9.3900000000000001E-18,0.8,24604202]
["WCadjBMI","rs4378999","rs7628533",0.99401799999999996,1.66312E-4,"CD14+ monocytes (2h LPS stimulated)","MAPKAPK3","rs7614881",7.3699999999999997E-6,0.8,24604202]
["WCadjBMI","rs4378999","rs7628533",0.99401799999999996,2.2593E-4,"CD14+ monocytes (2h LPS stimulated)","TEX264","rs1055429",8.0200000000000001E-7,0.8,24604202]
["WCadjBMI","rs4378999","rs7628533",0.99401799999999996,1.4500000000000001E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7630730",0.98232399999999997,9.63834E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs7630730",0.98232399999999997,9.1300000000000004E-22,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7630730",0.98232399999999997,3.8800000000000001E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs7640263",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7644957",0.98805900000000002,1.626244E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs7644957",0.98805900000000002,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7652655",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7652818",0.90468400000000004,2.46E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7653451",0.90468400000000004,7.3700000000000004E-16,"CD14+ monocytes (24h LPS stimulated)","MAPKAPK3","rs7614881",9.3900000000000001E-18,0.8,24604202]
["WCadjBMI","rs4378999","rs7653451",0.90468400000000004,2.9300000000000001E-5,"CD14+ monocytes (2h LPS stimulated)","MAPKAPK3","rs7614881",7.3699999999999997E-6,0.8,24604202]
["WCadjBMI","rs4378999","rs7653451",0.90468400000000004,2.1967800000000001E-4,"CD14+ monocytes (2h LPS stimulated)","TEX264","rs1055429",8.0200000000000001E-7,0.8,24604202]
["WCadjBMI","rs4378999","rs7653451",0.90468400000000004,3.6800000000000001E-9,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs7653451",0.90468400000000004,2.7900000000000001E-5,"Whole blood (Battle)","ACY1","rs7653451",2.7900000000000001E-5,0.8,24092820]
["WCadjBMI","rs4378999","rs922612",0.99401799999999996,1.6281049999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs922612",0.99401799999999996,1.03E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9682672",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9713241",0.90043799999999996,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9758600",0.90468400000000004,2.4799999999999999E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9828200",0.90468400000000004,3.8999999999999999E-12,"Monocytes","MAPKAPK3","rs6779819",1.47E-16,0.8,20502693]
["WCadjBMI","rs4378999","rs9828200",0.90468400000000004,2.4700000000000002E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9855442",0.99401799999999996,1.8102490000000001E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs9855442",0.99401799999999996,1.3E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9855454",0.98804899999999996,1.7800000000000001E-12,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9858412",0.98805900000000002,1.62542E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs9858412",0.98805900000000002,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9869123",0.98805900000000002,1.626548E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs9869123",0.98805900000000002,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9871539",0.98805900000000002,9.64984E-4,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs9871539",0.98805900000000002,8.8499999999999996E-22,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9871539",0.98805900000000002,3.8899999999999997E-5,"Subc adipose (MuTHER)","ARMET","rs6784455",3.27E-6,0.8,22941192]
["WCadjBMI","rs4378999","rs9878100",0.99401799999999996,1.8094039999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs9878100",0.99401799999999996,1.3E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs4378999","rs9883739",0.98216000000000003,1.6262469999999999E-3,"Peripheral blood mononuclear cells","TEX264","rs11130274",3.18091E-4,1,26019233]
["WCadjBMI","rs4378999","rs9883739",0.98216000000000003,1.0200000000000001E-24,"Peripheral blood mononuclear cells","GRM2","rs1055429",5.8000000000000004E-35,0.8,26019233]
["WCadjBMI","rs6012558","rs6012558","IndexSNP",7.4599999999999997E-5,"CD14+ monocytes (IFNg stimulated)","DDX27","rs6019512",2.5599999999999999E-5,0.87,24604202]
["WCadjBMI","rs6743226","rs4675966",0.97548400000000002,6.19E-6,"Blood","FARP2","rs4675966",6.19E-6,0.87,18344981]
["WCadjBMI","rs6743226","rs4675966",0.97548400000000002,4.0200000000000003E-7,"Lymph","HDLBP","rs4675966",4.0200000000000003E-7,0.87,17873875]
["WCadjBMI","rs6743226","rs4675966",0.97548400000000002,5.0500000000000001E-5,"Omental adipose","GAL3ST2","rs4675966",5.0500000000000001E-5,0.87,21602305]
["WCadjBMI","rs6743226","rs6747036",0.95255699999999999,1.37E-6,"LCL (GenCord)","ENSG00000115677.12","rs6747036",1.37E-6,0.84,23755361]
["WCadjBMI","rs6743226","rs6747036",0.95255699999999999,3.41E-7,"Primary PHA-stimulated T cells (GenCord)","ENSG00000115677.12","rs6747036",3.41E-7,0.84,23755361]
["WHRadjBMI","rs1049281","rs1049281","IndexSNP",2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs2844622",0.907829,1.5300000000000001E-284,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs7767581",0.93500399999999995,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264594",0.91238600000000003,2.2500000000000001E-233,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264594",0.91238600000000003,5.9200000000000002E-5,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264601",0.96172000000000002,1.65E-233,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264601",0.96172000000000002,6.1600000000000007E-5,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264602",0.986425,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264602",0.986425,"<6.7E-45","Whole blood (Battle)","HLA-L","rs9264602","<6.7E-45",0.96699999999999997,24092820]
["WHRadjBMI","rs1049281","rs9264603",0.97144900000000001,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264604",0.91843399999999997,2.59E-279,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264606",0.97400100000000001,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264608",0.98608700000000005,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264636",0.97191799999999995,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264638",0.91530199999999995,2.9199999999999999E-260,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264638",0.91530199999999995,5.12E-12,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1049281","rs9264647",0.93543799999999999,2.2300000000000001E-308,"Peripheral blood mononuclear cells","HLA-C","rs1049281",2.2300000000000001E-308,"SameSNP",26019233]
["WHRadjBMI","rs1856293","rs1856293",1,1.6500000000000001E-5,"Subc adipose (MuTHER)","TAAR6","rs799227",1.3200000000000001E-5,0.96699999999999997,22941192]
["WHRadjBMI","rs589428","rs605203",0.99463100000000004,6.3299999999999995E-20,"CD14+ monocytes (IFNg stimulated)","SKIV2L","rs486416",9.8399999999999999E-21,1,24604202]
["WHRadjBMI","rs589428","rs589428","IndexSNP",6.3299999999999995E-20,"CD14+ monocytes (IFNg stimulated)","SKIV2L","rs486416",9.8399999999999999E-21,1,24604202]

{"sheet":"ST 11. eQTL_FramHS_SNPadj","index":20,"n_rows":70,"n_cols":9,"rows_kept":70,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 11. Association of cis-eQTLs for novel loci in whole blood adjusting for smoking status."]
["Trait","Transcript","Tag SNP","CHR","POS","Gene","βmain","SEmain","Adj.Pvalue"]
["BMI",2339139,"rs2481665",1,62594677," INADL ",-2.4935081000000001E-2,4.2662150000000003E-3,8.9799999999999997E-8]
["BMI",2339334,"rs2481665",1,62594677," L1TD1 ",-1.6343488999999999E-2,5.4546380000000004E-3,1.8078457999999999E-2]
["WC",3061319,"rs10269774",7,92253972," CDK6 ",-1.0793135000000001E-2,3.7263079999999998E-3,2.4665033999999999E-2]
["WC",3060994,"rs10269774",7,92253972," CYP51A1 ",-3.3497516999999997E-2,8.9827880000000002E-3,1.7584650000000001E-3]
["WC",3012633,"rs10269774",7,92253972," GATAD1 ",-1.5560618999999999E-2,3.201508E-3,1.4600000000000001E-5]
["WC",2319661,"rs17396340",1,10286176," SLC12A4 ",0.17529150299999999,6.5846380000000003E-3,3.5199999999999999E-154]
["WC",2675239,"rs4378999",3,51208646," C6orf10 ",-1.1620767000000001E-2,4.2056990000000002E-3,3.571945E-2]
["WC",2622970,"rs4378999",3,51208646," C6orf174 ",1.1549227E-2,3.284244E-3,3.636584E-3]
["WC",2622859,"rs4378999",3,51208646," C6orf58 ",-3.7703183000000001E-2,4.832841E-3,1.53E-13]
["WC",2622912,"rs4378999",3,51208646," ECHDC1 ",-6.3222222999999994E-2,6.0407860000000002E-3,3.9999999999999997E-24]
["WC",2675504,"rs4378999",3,51208646," HLA-DOB ",1.8156022000000001E-2,5.838134E-3,1.3343531E-2]
["WC",2623139,"rs4378999",3,51208646," PTPRK ",-3.2019087000000002E-2,5.9814409999999997E-3,1.3599999999999999E-6]
["WC",2536298,"rs6743226",2,242236972," ACD ",-5.5661957999999997E-2,3.2153110000000002E-3,1.6299999999999999E-65]
["WC",2536531,"rs6743226",2,242236972," ACD ",1.5183014999999999E-2,2.7596579999999999E-3,6.0699999999999997E-7]
["WC",2607055,"rs6743226",2,242236972," CENPT ",9.8586500000000001E-3,2.6224830000000001E-3,1.5856049999999999E-3]
["WC",2607110,"rs6743226",2,242236972," CENPT ",1.6587738000000001E-2,5.4350279999999997E-3,1.5599663E-2]
["WHR",2902935,"rs1049281",6,31236567," AIF1 ",1.3158912E-2,3.7747929999999998E-3,3.9585319999999998E-3]
["WHR",2949311,"rs1049281",6,31236567," C2 ",1.2403763999999999E-2,3.3939640000000002E-3,2.244181E-3]
["WHR",2948587,"rs1049281",6,31236567," CSNK2B ",5.0802090000000001E-2,4.9270770000000002E-3,1.8400000000000001E-23]
["WHR",2949885,"rs1049281",6,31236567," CYP21A2 ",1.4103015E-2,3.8261979999999998E-3,2.0179109999999998E-3]
["WHR",2902178,"rs1049281",6,31236567," DPCR1 ",-1.8762759E-2,3.564967E-3,2.0499999999999999E-6]
["WHR",2902427,"rs1049281",6,31236567," HCG27 ",3.4783686000000001E-2,5.1564790000000003E-3,2.98E-10]
["WHR",2901463,"rs1049281",6,31236567," HLA-L ",1.3762706E-2,4.7620300000000004E-3,2.4874802000000001E-2]
["WHR",2949132,"rs1049281",6,31236567," HSPA1A ",2.2430275999999999E-2,3.5792380000000002E-3,6.7500000000000001E-9]
["WHR",2949230,"rs1049281",6,31236567," HSPA1B ",1.1195329E-2,3.7026149999999998E-3,1.6928449000000002E-2]
["WHR",2902804,"rs1049281",6,31236567," LST1 ",9.6033709999999994E-3,3.1929699999999998E-3,1.7626046999999999E-2]
["WHR",2948630,"rs1049281",6,31236567," LY6G5B ",3.3662462999999997E-2,4.6836650000000001E-3,1.5100000000000001E-11]
["WHR",2948648,"rs1049281",6,31236567," LY6G5B ",4.4411346999999997E-2,7.6325050000000004E-3,1.02E-7]
["WHR",2902574,"rs1049281",6,31236567," MICB ",2.8136279E-2,7.3371269999999997E-3,1.210458E-3]
["WHR",2948887,"rs1049281",6,31236567," MSH5 ",1.877681951,1.5225192E-2,"<1.264E-305"]
["WHR",2948926,"rs1049281",6,31236567," MSH5 ",0.12438231800000001,5.8467429999999997E-3,9.9300000000000001E-99]
["WHR",2902326,"rs1049281",6,31236567," MUC21 ",-5.5823200000000003E-2,5.4145520000000004E-3,1.8400000000000001E-23]
["WHR",2901552,"rs1049281",6,31236567," RPP21 ",1.7708580000000002E-2,5.7524619999999999E-3,1.4646398E-2]
["WHR",2949488,"rs1049281",6,31236567," SKIV2L ",0.127828999,5.6645289999999997E-3,6.3299999999999997E-111]
["WHR",2949588,"rs1049281",6,31236567," STK19 ",1.9772927999999999E-2,3.975152E-3,8.5599999999999994E-6]
["WHR",2902416,"rs1049281",6,31236567," TCF19 ",1.2399966E-2,4.3016560000000001E-3,2.5177689E-2]
["WHR",2902725,"rs1049281",6,31236567," TNF ",2.2216967000000001E-2,5.3587560000000001E-3,3.6384699999999999E-4]
["WHR",3115008,"rs2001945",8,126477978," TRIB1 ",1.2548076999999999E-2,3.7898039999999999E-3,7.0882150000000001E-3]
["WHR",2902884,"rs589428",6,31848220," AGER ",-1.3187463E-2,2.38083E-3,5.06E-7]
["WHR",2902958,"rs589428",6,31848220," AGER ",1.0621199E-2,2.2505250000000002E-3,2.7699999999999999E-5]
["WHR",2902935,"rs589428",6,31848220," AGER ",1.5093117E-2,3.6974320000000001E-3,4.7087300000000002E-4]
["WHR",2902804,"rs589428",6,31848220," AGPAT1 ",1.1353825999999999E-2,3.12999E-3,2.4555229999999998E-3]
["WHR",2950125,"rs589428",6,31848220," CIB2 ",2.4456979E-2,6.2728719999999996E-3,9.4800500000000003E-4]
["WHR",4048241,"rs589428",6,31848220," CTSH ",0.693750121,2.9460205999999999E-2,1.0100000000000001E-120]
["WHR",2902427,"rs589428",6,31848220," DOM3Z ",2.0220319E-2,5.0907909999999999E-3,7.2488299999999995E-4]
["WHR",2902326,"rs589428",6,31848220," EHMT2 ",-5.1880541000000002E-2,5.3528129999999997E-3,8.9200000000000003E-21]
["WHR",2902207,"rs589428",6,31848220," EHMT2 ",2.5564679E-2,4.8939939999999996E-3,2.4600000000000002E-6]
["WHR",2902178,"rs589428",6,31848220," EHMT2 ",-1.3412768E-2,3.5047139999999999E-3,1.2274880000000001E-3]
["WHR",2902574,"rs589428",6,31848220," FKBPL ",3.1680021000000003E-2,7.2081280000000003E-3,1.2436500000000001E-4]
["WHR",2902609,"rs589428",6,31848220," FKBPL ",1.5828828E-2,5.9182009999999997E-3,4.5870993999999998E-2]
["WHR",2903258,"rs589428",6,31848220," GPSM3 ",-5.6704388000000001E-2,7.397107E-3,4.2500000000000001E-13]
["WHR",2903219,"rs589428",6,31848220," GPSM3 ",0.14745127699999999,2.8362450000000001E-2,2.7599999999999998E-6]
["WHR",2949971,"rs589428",6,31848220," LINGO1 ",-7.4915768999999993E-2,7.9361780000000003E-3,9.7799999999999997E-20]
["WHR",2948887,"rs589428",6,31848220," MGC34034 ",0.85956010000000005,2.7995853000000001E-2,5.6799999999999999E-205]
["WHR",2949859,"rs589428",6,31848220," MORF4L1 ",-2.5002917999999999E-2,7.999038E-3,1.2982606000000001E-2]
["WHR",2949488,"rs589428",6,31848220," NDUFAF4 ",0.26742814100000001,4.3359130000000003E-3,"<1.264E-305"]
["WHR",2903189,"rs589428",6,31848220," PBX2 ",-3.2872946E-2,4.7063269999999997E-3,6.0199999999999996E-11]
["WHR",2903075,"rs589428",6,31848220," PBX2 ",1.1404031E-2,2.362299E-3,1.6799999999999998E-5]
["WHR",2902725,"rs589428",6,31848220," PRRT1 ",1.6693790999999999E-2,5.2761259999999999E-3,1.1697298E-2]
["WHR",4048265,"rs589428",6,31848220," RASGRF1 ",0.488385234,2.4768022000000001E-2,6.8600000000000003E-85]
["WHR",2949885,"rs589428",6,31848220," RASGRF1 ",1.1885957000000001E-2,3.7611570000000002E-3,1.1697298E-2]
["WHR",2949132,"rs589428",6,31848220," STX7 ",1.8884620000000001E-2,3.5327069999999999E-3,1.37E-6]
["WHR",2949148,"rs589428",6,31848220," TAAR5 ",-2.4884119E-2,5.0955760000000001E-3,1.33E-5]
["WHR",2948926,"rs589428",6,31848220," TCF21 ",8.9165053999999994E-2,5.9277360000000003E-3,1.43E-49]
["WHR",2902463,"rs589428",6,31848220," TNXB ",1.2874673E-2,3.4834219999999999E-3,1.971324E-3]
["WHR",2949230,"rs589428",6,31848220," VNN1 ",1.4189883E-2,3.6383729999999999E-3,9.4800500000000003E-4]
["WHR",2902348,"rs589428",6,31848220," ZBTB12 ",-2.4641887000000001E-2,3.681447E-3,4.1300000000000002E-10]
["WHR",2949311,"rs589428",6,31848220,"DDAH2",1.5900692000000001E-2,3.3260070000000002E-3,2.09E-5]

{"sheet":"ST 12. eQTL_FramHS_SNPjoint","index":21,"n_rows":30,"n_cols":12,"rows_kept":30,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 12. Association of cis-eQTLs for novel loci in whole blood for joint main + smoking ineraction."]
["Trait","Transcript","Tag SNP","CHR","POS","Gene","βmain","SEmain","βint","SEmain","Covmain","Adj. Pvalue"]
["BMI",3603436,"rs12902602",15,78967401," CHRNA5 ",-3.6260000000000001E-2,4.1269999999999996E-3,7.3210000000000003E-3,1.3299999999999999E-2,-1.6699999999999999E-5,4.2400000000000002E-17]
["BMI",3634811,"rs12902602",15,78967401," CTSH ",3.209E-2,5.4879999999999998E-3,-7.2420000000000002E-3,1.7409999999999998E-2,-2.87E-5,2.4900000000000002E-7]
["BMI",3603408,"rs12902602",15,78967401," PSMA4 ",-3.678E-2,5.9249999999999997E-3,-1.281E-2,1.9019999999999999E-2,-3.4199999999999998E-5,2.6099999999999999E-9]
["WC",2319661,"rs17396340",1,10286176," KIF1B ",-0.17780000000000001,6.8910000000000004E-3,2.3949999999999999E-2,2.162E-2,-4.5500000000000001E-5,4.8100000000000003E-154]
["WC",2536531,"rs6743226",2,242236972," FARP2 ",-1.5810000000000001E-2,2.8860000000000001E-3,5.1529999999999996E-3,9.4230000000000008E-3,-8.0099999999999995E-6,2.7700000000000002E-6]
["WC",2607110,"rs6743226",2,242236972," HDLBP ",1.823E-2,5.6559999999999996E-3,-8.0929999999999995E-3,1.8540000000000001E-2,-3.1000000000000001E-5,4.2608874999999997E-2]
["WC",2607055,"rs6743226",2,242236972," PASK ",-1.0449999999999999E-2,2.7390000000000001E-3,5.4219999999999997E-3,8.8059999999999996E-3,-6.9800000000000001E-6,6.5276969999999998E-3]
["WC",2536298,"rs6743226",2,242236972," SEPT2 ",5.5320000000000001E-2,3.3219999999999999E-3,-2.6740000000000002E-3,1.0500000000000001E-2,-9.8900000000000002E-6,8.7000000000000003E-64]
["WHR",2949311,"rs1049281",6,31236567," DDAH2 ",1.2529999999999999E-2,3.5750000000000001E-3,-2.3219999999999998E-3,1.1270000000000001E-2,-1.26E-5,1.3618194E-2]
["WHR",2949588,"rs1049281",6,31236567," DOM3Z ",1.789E-2,4.1850000000000004E-3,2.1389999999999999E-2,1.3270000000000001E-2,-1.7499999999999998E-5,1.2799999999999999E-5]
["WHR",2948587,"rs1049281",6,31236567," FLOT1 ",-4.8640000000000003E-2,5.1549999999999999E-3,-1.3610000000000001E-2,1.5879999999999998E-2,-2.51E-5,6.3900000000000001E-22]
["WHR",2949885,"rs1049281",6,31236567," GPSM3 ",1.243E-2,4.0260000000000001E-3,1.338E-2,1.269E-2,-1.5999999999999999E-5,8.9216569999999995E-3]
["WHR",2902326,"rs1049281",6,31236567," HCP5 ",-5.3350000000000002E-2,5.6899999999999997E-3,-2.6100000000000002E-2,1.7579999999999998E-2,-3.0800000000000003E-5,7.54E-23]
["WHR",2948926,"rs1049281",6,31236567," HLA-B ",-0.12479999999999999,6.1330000000000004E-3,5.888E-3,1.8540000000000001E-2,-3.43E-5,1.07E-96]
["WHR",2902725,"rs1049281",6,31236567," HSPA1B ",2.1190000000000001E-2,5.6379999999999998E-3,8.3890000000000006E-3,1.7610000000000001E-2,-3.0899999999999999E-5,2.1918390000000001E-3]
["WHR",2948630,"rs1049281",6,31236567," IER3 ",2.9170000000000001E-2,4.9259999999999998E-3,4.4209999999999999E-2,1.541E-2,-2.3600000000000001E-5,2.69E-12]
["WHR",2902427,"rs1049281",6,31236567," LST1 ",-3.4450000000000001E-2,5.4260000000000003E-3,-3.0920000000000001E-3,1.694E-2,-2.8600000000000001E-5,2.8299999999999999E-9]
["WHR",2902574,"rs1049281",6,31236567," LY6G5B ",3.1890000000000002E-2,7.6509999999999998E-3,-2.1350000000000001E-2,2.4E-2,-5.7299999999999997E-5,1.818783E-3]
["WHR",2949132,"rs1049281",6,31236567," NCR3 ",-2.3130000000000001E-2,3.7669999999999999E-3,7.5199999999999998E-3,1.176E-2,-1.38E-5,5.17E-8]
["WHR",2948648,"rs1049281",6,31236567," NCRNA00243 ",4.079E-2,8.0079999999999995E-3,4.3490000000000001E-2,2.4570000000000002E-2,-6.02E-5,9.6400000000000003E-8]
["WHR",2901552,"rs1049281",6,31236567," RPP21 ",1.873E-2,6.0470000000000003E-3,-3.5590000000000001E-3,1.917E-2,-3.65E-5,4.9497143E-2]
["WHR",2949488,"rs1049281",6,31236567," SLC44A4 ",-0.12509999999999999,5.9300000000000004E-3,-2.214E-2,1.779E-2,-3.1600000000000002E-5,4.9800000000000002E-109]
["WHR",2902935,"rs1049281",6,31236567," STK19 ",1.406E-2,3.9750000000000002E-3,-7.3509999999999999E-3,1.2579999999999999E-2,-1.5699999999999999E-5,1.5414473999999999E-2]
["WHR",2902178,"rs1049281",6,31236567," TCF19 ",2.0449999999999999E-2,3.7450000000000001E-3,-2.0379999999999999E-2,1.172E-2,-1.3699999999999999E-5,5.4199999999999998E-6]
["WHR",2948887,"rs1049281",6,31236567,"NA*",1.88,1.5970000000000002E-2,-3.048E-2,4.8489999999999998E-2,-2.3470000000000001E-4,"<1.754E-321"]
["WHR",2974671,"rs1856293",6,133480940," C6orf192 ",-2.827E-2,6.7850000000000002E-3,-1.251E-2,2.1000000000000001E-2,-4.2700000000000001E-5,3.2145900000000001E-4]
[]
["*The transcript id is \"2948887 \" according to the affymetrix exon array annotation. Gene symbol is null, entrze gene id is null. "]

{"sheet":"ST 13. GWASCatalog","index":22,"n_rows":40,"n_cols":19,"rows_kept":40,"cut":false,"hidden":false,"merged":[[1,2,1,3],[1,5,1,11]]}
["Supplementary Table 13. GWAS Catalog lookups for novel loci."]
[null,null,"Current Study SNP",null,null,"Previously Identified SNP"]
["TRAIT","CHR","rsID","POS (hg19)","Distance","rsID","POS","Risk Allele (RA)","RA freq","r2","P","OR/Beta","Disease/Trait","PUBMEDID","Discovery Sample Size","Replication Sample Size","Reported Gene","Mapped Gene","Annotation"]
["BMI",15,"rs12902602",78967401,73062,"rs1051730",78894339,"G",0.65,0.52227000000000001,3.0000000000000001E-73,-1.02,"Smoking behavior",20418890,74035,68988,"CHRNA3","CHRNA3","STOP-GAIN"]
["BMI",15,"rs12902602",78967401,73062,"rs1051730",78894339,"G",0.66,0.52227000000000001,2E-66,-0.08,"Smoking behavior",20418889,41150,120516,"CHRNA5, CHRNA3","CHRNA3","STOP-GAIN"]
["BMI",15,"rs12902602",78967401,73062,"rs1051730",78894339,"T",0.35,0.52227000000000001,2E-51,1.31,"Lung adenocarcinoma",19836008,{"$f":"5739+5848","v":11587},{"$f":"7561+13818","v":21379},"CHRNA5, CHRNA3","CHRNA3","STOP-GAIN"]
["BMI",15,"rs12902602",78967401,73062,"rs1051730",78894339,"T",0.35,0.52227000000000001,6.0000000000000006E-20,0.1,"Nicotine dependence",18385739,10995,4848,"CHRNA5, CHRNA3, CHRNB4","CHRNA3","STOP-GAIN"]
["BMI",15,"rs12902602",78967401,73062,"rs1051730",78894339,"A",0.34,0.52227000000000001,1.9999999999999999E-69,0.8,"Smoking behavior",20418888,31266,54731,"NR","CHRNA3","STOP-GAIN"]
["BMI",15,"rs12902602",78967401,73062,"rs1051730",78894339,"A","NR",0.52227000000000001,1.0000000000000001E-15,1.35,"Lung cancer",18978790,{"$f":"2971+3746","v":6717},{"$f":"2899+5573","v":8472},"intergenic","CHRNA3","STOP-GAIN"]
["BMI",15,"rs12902602",78967401,112833,"rs1994016",79080234,"C",0.6,0.55928699999999998,4.9999999999999999E-13,1.19,"Coronary artery disease",21239051,{"$f":"1808+915","v":2723},{"$f":"10585+6468","v":17053},"ADAMTS7","ADAMTS7","intron"]
["BMI",15,"rs12902602",78967401,121710,"rs3825807",79089111,"A",0.56999999999999995,0.52832999999999997,9.9999999999999998E-13,1.08,"Coronary heart disease",21378990,{"$f":"22233+64762","v":86995},56682,"ADAMTS7","ADAMTS7","missense"]
["BMI",15,"rs12902602",78967401,121710,"rs3825807",79089111,"A",0.56999999999999995,0.52832999999999997,6.9999999999999999E-6,0.36299999999999999,"Coronary artery calcification",23561647,2620,"NA","ADAMTS7","ADAMTS7","missense"]
["WCadjBMI",1,"rs17396340",10286176,0,"rs17396340",10286176,"A","NR",1,2.9999999999999997E-8,8.0000000000000002E-3,"Mean platelet volume",22139419,{"$f":"16948+1652","v":18600},18838,"KIF1B","KIF1B, MIR1273D","intron;nearGene-5"]
["WCadjBMI",3,"rs4378999",51208646,170628,"rs1031925",51379274,"NR",null,0.75644900000000004,7.9999999999999996E-6,1.1499999999999999,"Melanoma",24980573,{"$f":"494+5628","v":6122},{"$f":"5383+13033","v":18416},"DOCK3","DOCK3","intron"]
["WCadjBMI",4,"rs7697556",73515313,39299,"rs9993613",73476014,"T",0.47299999999999998,0.98661699999999997,4.9999999999999998E-24,0.03,"Height",25282103,253288,80067,"ADAMTS3","ADAMTS3 - HNRNPA1P67","intergenic"]
["WCadjBMI",4,"rs7697556",73515313,0,"rs7697556",73515313,"T",0.47,1,2E-14,2.8000000000000001E-2,"Height",20881960,133653,50074,"ADAMTS3","ADAMTS3 - HNRNPA1P67","intergenic"]
["WCadjBMI",7,"rs10269774",92253972,5896,"rs42235",92248076,"T",0.31,0.67919600000000002,7.9999999999999998E-47,5.7000000000000002E-2,"Height",20881960,133653,50074,"CDK6","CDK6","intron"]
["WCadjBMI",7,"rs10269774",92253972,5896,"rs42235",92248076,"T",0.3,0.67919600000000002,9.9999999999999997E-29,1.28,"Height",23563607,{"$f":"8097+8099","v":16196},{"$f":"4872+4831","v":9703},"CDK6","CDK6","intron"]
["WCadjBMI",7,"rs10269774",92253972,10438,"rs2282978",92264410,"NR",0.08,0.92062699999999997,1E-8,-0.06,"Height",19343178,12611,7187,"CDK6","CDK6","intron"]
["WCadjBMI",7,"rs10269774",92253972,10438,"rs2282978",92264410,"C",0.28999999999999998,0.92062699999999997,1E-8,5.8,"Height",18391951,30968,8541,"CDK6, ERVWE1, GATAD1, PEX1","CDK6","intron"]
["WCadjBMI",7,"rs10269774",92253972,10438,"rs2282978",92264410,"C",0.33,0.92062699999999997,7.9999999999999997E-23,0.09,"Height",18391952,13665,16482,"CDK6","CDK6","intron"]
["WCadjBMI",8,"rs6470765",130736697,12969,"rs4733724",130723728,"A",0.80200000000000005,0.92094500000000001,1E-41,0.05,"Height",25282103,253288,80067,"MLZE","MIR3686 - GSDMC","intergenic"]
["WCadjBMI",8,"rs6470765",130736697,11032,"rs6470764",130725665,"T",0.2,0.91113100000000002,1.9999999999999999E-28,0.05,"Height",20881960,133653,50074,"GSDMC","MIR3686 - GSDMC","intergenic"]
["WCadjBMI",8,"rs6470765",130736697,11032,"rs6470764",130725665,"T",0.20300000000000001,0.91113100000000002,9.9999999999999995E-7,5.3999999999999999E-2,"Infant length",25281659,28238,"NA","GSDMC","MIR3686 - GSDMC","intergenic"]
["WCadjBMI",8,"rs6470765",130736697,2236,"rs2062078",130734461,"T",0.73,0.99277700000000002,1E-13,3.2000000000000001E-2,"Height",25429064,36227,57699,"GSDMC","MIR3686 - GSDMC","intergenic"]
["WHRadjBMI",6,"rs1049281",31344546,4456,"rs3130542",31340090,"A",0.13,0.72039699999999995,8.9999999999999995E-14,1.33,"Hepatitis B",24162738,{"$f":"951 + 937","v":1888},{"$f":"4230+3051+2622","v":9903},"HLA-C","TRNAI25"]
["WHRadjBMI",6,"rs1049281",31344546,1751,"rs9264638",31346297,"A",0.57999999999999996,0.91530199999999995,1.9999999999999999E-23,-0.04,"Beta-2 microglubulin plasma levels",23417110,6728,null,"HLA-C","HLA-C","intron"]
["WHRadjBMI",6,"rs1049281",31344546,15829,"rs2524054",31360375,"A",0.32,0.79928999999999994,1.9999999999999999E-28,0.37,"CD4:CD8 lymphocyte ratio",20045101,{"$f":"2538+1089","v":3627},988,"HLA-B","TRNAI25"]
["WHRadjBMI",6,"rs1049281",31344546,15829,"rs2524054",31360375,"A",0.32,0.79928999999999994,5.9999999999999998E-21,-0.31,"CD4:CD8 lymphocyte ratio",20045101,{"$f":"2538+1089","v":3627},988,"HLA-B","TRNAI25"]
["WHRadjBMI",6,"rs1049281",31344546,28923,"rs2247056",31373469,"T",0.25,0.85334699999999997,2.0000000000000002E-15,-2.99,"Triglycerides",20686565,96598,"NA","HLA","TRNAI25"]
["WHRadjBMI",6,"rs1049281",31344546,28923,"rs2247056",31373469,"T",0.27,0.85334699999999997,3.9999999999999999E-12,1.18,"Height",23563607,{"$f":"8097+8099","v":16196},{"$f":"4872+4831","v":9703},"HLA-B, HLA-C","TRNAI25"]
["WHRadjBMI",6,"rs1049281",31344546,35694,"rs6457374",31380240,"T",0.73,0.85757700000000003,8.0000000000000001E-35,-4.1000000000000002E-2,"Height",25282103,253288,80067,"HLA-C","WASF5P - HLA-B","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,0,"rs2001945",126477978,"C",0.42,1,9.9999999999999995E-21,4.0500000000000001E-2,"Triglycerides",21909109,{"$f":"12545","v":12545},30395,"intergenic","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,4099,"rs2954021",126482077,"G",0.5,0.81640299999999999,9.9999999999999995E-8,-0.02,"LDL cholesterol",20864672,17723,{"$f":"37774+9665","v":47439},"TRIB1","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,4099,"rs2954021",126482077,"A",0.5,0.81640299999999999,5.0000000000000001E-9,1.6,"Liver enzyme levels (alanine transaminase)",22001757,{"$f":"52350+8739","v":61089},"NA","TRIB1","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,4099,"rs2954021",126482077,"A",0.5,0.81640299999999999,2.0000000000000001E-13,1.4,"Liver enzyme levels (alkaline phosphatase)",22001757,{"$f":"52350+8739","v":61089},"NA","TRIB1","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,8431,"rs17321515",126486409,"A",0.47,0.610514,7.9999999999999996E-7,7.0000000000000007E-2,"Lipid traits",24386095,{"$f":"3451","v":3451},8830,"TRIB1","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,8431,"rs17321515",126486409,"A",0.56000000000000005,0.610514,7.0000000000000005E-13,6.42,"Triglycerides",18193043,8684,9741,"TRIB1","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",8,"rs2001945",126477978,8431,"rs17321515",126486409,"G",0.49,0.610514,4.0000000000000003E-17,0.08,"Triglycerides",18193044,2758,18544,"TRIB1","TRIB1 - LINC00861","intergenic"]
["WHRadjBMI",13,"rs17065323",44627788,0,"rs17065323",44627788,"NR","NR",1,3.9999999999999998E-6,-4.29,"Uric acid levels",18759275,{"$f":"408 + 460","v":868},null,"NR","LINC00284 - SMIM2-AS1","intergenic"]

{"sheet":"ST 14. Lookup of Smoking Loci","index":23,"n_rows":36,"n_cols":21,"rows_kept":36,"cut":false,"hidden":false,"merged":[[25,0,25,1],[1,6,2,6],[1,7,2,7],[1,10,1,12],[1,13,1,15],[1,16,1,20],[14,0,14,1],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,2,4],[1,5,2,5]]}
["Supplementary Table 14. Lookups of previously identified smoking loci in current combined ancestries meta-analyses results for BMI, WCadjBMI and WHRadjBMI."]
["SNPS","CHR","POS(hg19)","DISEASE/TRAIT","REPORTED GENE(S)","PUBMEDID","Effect Allele","Other Allele",null,null,"SMOKERS",null,null,"NON-SMOKERS",null,null,"MAIN and INTERACTION EFFECTS"]
[{"$nulls":8},"EAF","N","β","SE","P","β","SE","P","βadj","SEadj","Padj","Pint","Pjoint"]
["BMI"]
["rs1451240",8,42546711,"Nicotine dependence","CHRNB3",22524403,"A","G",0.26279999999999998,149164,-1.06E-2,9.9000000000000008E-3,0.28389999999999999,2.9999999999999997E-4,5.4000000000000003E-3,0.96309999999999996,-2.5000000000000001E-3,4.7999999999999996E-3,0.60409999999999997,0.30443724,0.56284555000000003]
["rs6474412",8,42550498,"Smoking behavior","CHRNB3, CHRNA6",20418888,"T","C",0.73960000000000004,173262,7.3000000000000001E-3,9.5999999999999992E-3,0.44750000000000001,-3.2000000000000002E-3,5.0000000000000001E-3,0.52380000000000004,-5.9999999999999995E-4,4.4999999999999997E-3,0.89029999999999998,0.30348491,0.61023158]
["rs3025343",9,136478355,"Smoking behavior (cessation)","DBH",20418890,"A","G",0.1157,168375,-3.5299999999999998E-2,1.3899999999999999E-2,1.1379999999999999E-2,-1.26E-2,7.6E-3,9.6930000000000002E-2,-1.8700000000000001E-2,6.6E-3,4.3420000000000004E-3,0.12787056999999999,1.0061779999999999E-2]
["rs1329650",10,93348120,"Smoking behavior (CPD)","LOC100188947",20418890,"T","G",0.30009999999999998,174980,2.8E-3,9.1000000000000004E-3,0.75519999999999998,-8.0000000000000002E-3,4.7000000000000002E-3,9.1329999999999995E-2,-6.1000000000000004E-3,4.1999999999999997E-3,0.15090000000000001,0.26348529999999998,0.22403419999999999]
["rs6265",11,27679916,"Smoking behavior (initiation)","BDNF",20418890,"T","C",0.19309999999999999,217329,-6.13E-2,9.1999999999999998E-3,2.485E-11,-4.1300000000000003E-2,5.0000000000000001E-3,1.311E-16,-4.2999999999999997E-2,4.4000000000000003E-3,8.132E-23,4.2444210000000003E-2,3.5000000000000002E-25]
["rs2036527",15,78851615,"Smoking behavior (CPD)","CHRNA5",22832964,"A","G",0.33119999999999999,240437,-3.9100000000000003E-2,7.4000000000000003E-3,1.111E-7,1.6000000000000001E-3,3.8999999999999998E-3,0.68920000000000003,-7.4000000000000003E-3,3.3999999999999998E-3,2.9749999999999999E-2,2.4250000000000001E-7,7.963E-7]
["rs1051730",15,78894339,"Smoking behavior (CPD, nicotine dependence)","CHRNA3","20418890; 20418888; 20418889; 18385739","A","G",0.32850000000000001,215806,-4.0800000000000003E-2,7.6E-3,8.5310000000000001E-8,1.8E-3,4.1000000000000003E-3,0.66359999999999997,-7.7999999999999996E-3,3.5999999999999999E-3,3.0939999999999999E-2,1.6110000000000001E-7,5.0119999999999996E-7]
["rs3733829",19,41310571,"Smoking behavior (CPD)","EGLN2, CYP2A6",20418890,"A","G",0.64219999999999999,183652,-3.0000000000000001E-3,8.6E-3,0.72870000000000001,2.0000000000000001E-4,4.4999999999999997E-3,0.95879999999999999,-2.0000000000000001E-4,4.0000000000000001E-3,0.95479999999999998,0.72650999000000005,0.94004140999999997]
["rs4105144",19,41358624,"Smoking behavior","CYP2A6, RAB4D",20418888,"T","C",0.31169999999999998,135367,3.3E-3,1.11E-2,0.76619999999999999,-2.5999999999999999E-3,6.1999999999999998E-3,0.67500000000000004,-1.5E-3,5.3E-3,0.7772,0.62169562,0.87623401999999995]
["rs8102683",19,41363765,"Smoking behavior","CYP2A6",23049750,"T","C",0.26590000000000003,157411,5.7000000000000002E-3,1.0699999999999999E-2,0.59399999999999997,-1E-4,5.7000000000000002E-3,0.98060000000000003,1.6000000000000001E-3,5.1000000000000004E-3,0.75260000000000005,0.61153915999999997,0.86758307000000001]
["WCadjBMI"]
["rs1451240",8,42546711,"Nicotine dependence","CHRNB3",22524403,"A","G",0.24590000000000001,120877,-7.0000000000000001E-3,1.09E-2,0.52200000000000002,8.0000000000000002E-3,5.8999999999999999E-3,0.17979999999999999,7.4000000000000003E-3,5.3E-3,0.1618,0.20341493999999999,0.32449418000000002]
["rs6474412",8,42550498,"Smoking behavior","CHRNB3, CHRNA6",20418888,"T","C",0.75370000000000004,142297,5.8999999999999999E-3,1.06E-2,0.57599999999999996,-4.7999999999999996E-3,5.4000000000000003E-3,0.37290000000000001,-4.8999999999999998E-3,4.8999999999999998E-3,0.32479999999999998,0.34537391000000001,0.57696965]
["rs3025343",9,136478355,"Smoking behavior (cessation)","DBH",20418890,"A","G",0.1164,138287,1E-4,1.52E-2,0.99719999999999998,2.4500000000000001E-2,8.0000000000000002E-3,2.1940000000000002E-3,1.54E-2,7.1999999999999998E-3,3.338E-2,0.13578108,9.19151E-3]
["rs1329650",10,93348120,"Smoking behavior (CPD)","LOC100188947",20418890,"T","G",0.3095,143896,7.1000000000000004E-3,9.7000000000000003E-3,0.46560000000000001,1.1000000000000001E-3,5.0000000000000001E-3,0.82030000000000003,5.9999999999999995E-4,4.4999999999999997E-3,0.89570000000000005,0.56393793000000003,0.74670744]
["rs6265",11,27679916,"Smoking behavior (initiation)","BDNF",20418890,"T","C",0.19489999999999999,185265,5.0000000000000001E-3,9.7000000000000003E-3,0.60509999999999997,-2.7000000000000001E-3,5.1999999999999998E-3,0.61009999999999998,-1.9E-3,4.7000000000000002E-3,0.68720000000000003,0.46230147999999999,0.76517415]
["rs2036527",15,78851615,"Smoking behavior (CPD)","CHRNA5",22832964,"A","G",0.33279999999999998,203471,9.4999999999999998E-3,7.7000000000000002E-3,0.2203,-3.0000000000000001E-3,4.1000000000000003E-3,0.46560000000000001,-1.1000000000000001E-3,3.7000000000000002E-3,0.76690000000000003,0.13227428999999999,0.35744014000000002]
["rs1051730",15,78894339,"Smoking behavior (CPD, nicotine dependence)","CHRNA3","20418890; 20418888; 20418889; 18385739","A","G",0.33090000000000003,183565,6.6E-3,8.0000000000000002E-3,0.40600000000000003,-2.3999999999999998E-3,4.4000000000000003E-3,0.5766,-1E-4,3.8999999999999998E-3,0.96950000000000003,0.30000125999999999,0.61319467000000005]
["rs3733829",19,41310571,"Smoking behavior (CPD)","EGLN2, CYP2A6",20418890,"A","G",0.63829999999999998,154278,-0.01,9.1999999999999998E-3,0.27850000000000003,-4.5999999999999999E-3,4.7999999999999996E-3,0.33829999999999999,-5.7000000000000002E-3,4.3E-3,0.18279999999999999,0.58484851999999998,0.34995923000000001]
["rs4105144",19,41358624,"Smoking behavior","CYP2A6, RAB4D",20418888,"T","C",0.31059999999999999,117256,6.0000000000000001E-3,1.1900000000000001E-2,0.61409999999999998,-7.1999999999999998E-3,6.4999999999999997E-3,0.26800000000000002,-3.3999999999999998E-3,5.7000000000000002E-3,0.55079999999999996,0.30614476000000002,0.47682735999999998]
["rs8102683",19,41363765,"Smoking behavior","CYP2A6",23049750,"T","C",0.26800000000000002,130065,7.9000000000000008E-3,1.18E-2,0.50270000000000004,-4.5999999999999999E-3,6.1999999999999998E-3,0.46189999999999998,-1.6000000000000001E-3,5.7000000000000002E-3,0.77659999999999996,0.32477830000000002,0.60692893000000003]
["WHRadjBMI"]
["rs1451240",8,42546711,"Nicotine dependence","CHRNB3",22524403,"A","G",0.2402,106301,-1.0999999999999999E-2,1.0999999999999999E-2,0.31909999999999999,6.7000000000000002E-3,6.4000000000000003E-3,0.29270000000000002,4.1999999999999997E-3,5.4999999999999997E-3,0.44219999999999998,0.15209375999999999,0.35064757000000002]
["rs6474412",8,42550498,"Smoking behavior","CHRNB3, CHRNA6",20418888,"T","C",0.7591,126252,1.15E-2,1.06E-2,0.27650000000000002,-1.6000000000000001E-3,5.7000000000000002E-3,0.77459999999999996,-6.9999999999999999E-4,5.0000000000000001E-3,0.89070000000000005,0.26294232000000001,0.53370775000000004]
["rs3025343",9,136478355,"Smoking behavior (cessation)","DBH",20418890,"A","G",0.1167,121686,-8.2000000000000007E-3,1.52E-2,0.58960000000000001,1.0800000000000001E-2,8.8000000000000005E-3,0.21779999999999999,3.5999999999999999E-3,7.4000000000000003E-3,0.62890000000000001,0.26533478999999999,0.40713311000000002]
["rs1329650",10,93348120,"Smoking behavior (CPD)","LOC100188947",20418890,"T","G",0.3115,129224,4.4000000000000003E-3,9.7000000000000003E-3,0.65490000000000004,-4.4999999999999997E-3,5.3E-3,0.3931,-2.5000000000000001E-3,4.4999999999999997E-3,0.58320000000000005,0.40748964999999998,0.62918574000000005]
["rs6265",11,27679916,"Smoking behavior (initiation)","BDNF",20418890,"T","C",0.1963,166380,-2.9999999999999997E-4,5.3E-3,0.95179999999999998,-8.0000000000000004E-4,3.8999999999999998E-3,0.83009999999999995,-1.4E-3,4.7999999999999996E-3,0.76060000000000005,0.93744841000000001,0.97761359999999997]
["rs2036527",15,78851615,"Smoking behavior (CPD)","CHRNA5",22832964,"A","G",0.3332,188062,1.4E-3,4.0000000000000001E-3,0.71599999999999997,-5.0000000000000001E-4,2.8999999999999998E-3,0.85499999999999998,2.9999999999999997E-4,3.7000000000000002E-3,0.93559999999999999,0.69127863000000001,0.92671124000000005]
["rs1051730",15,78894339,"Smoking behavior (CPD, nicotine dependence)","CHRNA3","20418890; 20418888; 20418889; 18385739","A","G",0.33200000000000002,166117,1.1000000000000001E-3,4.0000000000000001E-3,0.78849999999999998,2.0000000000000001E-4,3.0000000000000001E-3,0.93969999999999998,6.9999999999999999E-4,3.8999999999999998E-3,0.85389999999999999,0.85249269000000005,0.96075608000000001]
["rs3733829",19,41310571,"Smoking behavior (CPD)","EGLN2, CYP2A6",20418890,"A","G",0.6371,137052,-4.4000000000000003E-3,9.1000000000000004E-3,0.62690000000000001,-4.8999999999999998E-3,5.1000000000000004E-3,0.3332,-5.1000000000000004E-3,4.4000000000000003E-3,0.2495,0.96065772999999999,0.56076837000000002]
["rs4105144",19,41358624,"Smoking behavior","CYP2A6, RAB4D",20418888,"T","C",0.31369999999999998,102594,1.04E-2,1.2E-2,0.3861,-9.4999999999999998E-3,6.8999999999999999E-3,0.1686,-4.1000000000000003E-3,5.7999999999999996E-3,0.47960000000000003,0.138844,0.26623906000000003]
["rs8102683",19,41363765,"Smoking behavior","CYP2A6",23049750,"T","C",0.26950000000000002,113338,8.3999999999999995E-3,1.18E-2,0.48049999999999998,-1.37E-2,6.6E-3,3.9199999999999999E-2,-7.6E-3,5.7000000000000002E-3,0.1822,9.2535329999999999E-2,9.0016689999999996E-2]

{"sheet":"ST 15. Validation in UKBB","index":24,"n_rows":108,"n_cols":28,"rows_kept":108,"cut":false,"hidden":false,"merged":[[0,0,0,27],[105,7,107,7],[105,1,107,1],[105,2,107,2],[105,3,107,3],[105,4,107,4],[105,5,107,5],[105,6,107,6],[99,7,101,7],[102,1,104,1],[102,2,104,2],[102,3,104,3],[102,4,104,4],[102,5,104,5],[102,6,104,6],[102,7,104,7],[99,1,101,1],[99,2,101,2],[99,3,101,3],[99,4,101,4],[99,5,101,5],[99,6,101,6],[93,7,95,7],[96,1,98,1],[96,2,98,2],[96,3,98,3],[96,4,98,4],[96,5,98,5],[96,6,98,6],[96,7,98,7],[93,1,95,1],[93,2,95,2],[93,3,95,3],[93,4,95,4],[93,5,95,5],[93,6,95,6],[87,7,89,7],[90,1,92,1],[90,2,92,2],[90,3,92,3],[90,4,92,4],[90,5,92,5],[90,6,92,6],[90,7,92,7],[87,4,89,4],[87,5,89,5],[87,6,89,6],[87,1,89,1],[87,2,89,2],[87,3,89,3],[81,7,83,7],[84,4,86,4],[84,5,86,5],[84,6,86,6],[84,7,86,7],[81,4,83,4],[81,5,83,5],[81,6,83,6],[75,7,77,7],[78,4,80,4],[78,5,80,5],[78,6,80,6],[84,1,86,1],[84,2,86,2],[84,3,86,3],[81,1,83,1],[81,2,83,2],[81,3,83,3],[78,1,80,1],[78,2,80,2],[78,3,80,3],[75,1,77,1],[75,2,77,2],[75,3,77,3],[72,1,74,1],[72,2,74,2],[72,3,74,3],[78,7,80,7],[75,4,77,4],[75,5,77,5],[75,6,77,6],[69,7,71,7],[72,4,74,4],[72,5,74,5],[72,6,74,6],[72,7,74,7],[69,1,71,1],[69,2,71,2],[69,3,71,3],[69,4,71,4],[69,5,71,5],[69,6,71,6],[62,7,64,7],[65,1,67,1],[65,2,67,2],[65,3,67,3],[65,4,67,4],[65,5,67,5],[65,6,67,6],[65,7,67,7],[62,1,64,1],[62,2,64,2],[62,3,64,3],[62,4,64,4],[62,5,64,5],[62,6,64,6],[56,7,58,7],[59,1,61,1],[59,2,61,2],[59,3,61,3],[59,4,61,4],[59,5,61,5],[59,6,61,6],[59,7,61,7],[56,1,58,1],[56,2,58,2],[56,3,58,3],[56,4,58,4],[56,5,58,5],[53,1,55,1],[53,2,55,2],[53,3,55,3],[53,4,55,4],[53,5,55,5],[50,1,52,1],[50,2,52,2],[50,3,52,3],[50,4,52,4],[50,5,52,5],[47,2,49,2],[47,3,49,3],[47,4,49,4],[47,5,49,5],[25,7,27,7],[25,1,27,1],[25,2,27,2],[25,3,27,3],[25,4,27,4],[25,5,27,5],[25,6,27,6],[41,1,43,1],[41,2,43,2],[38,1,40,1],[38,2,40,2],[38,4,40,4],[38,5,40,5],[38,6,40,6],[32,7,34,7],[35,1,37,1],[35,2,37,2],[35,3,37,3],[35,4,37,4],[35,5,37,5],[22,1,24,1],[22,2,24,2],[56,6,58,6],[50,7,52,7],[53,6,55,6],[53,7,55,7],[50,6,52,6],[44,7,46,7],[47,6,49,6],[47,7,49,7],[44,3,46,3],[44,4,46,4],[44,5,46,5],[44,6,46,6],[38,7,40,7],[41,3,43,3],[41,4,43,4],[41,5,43,5],[41,6,43,6],[41,7,43,7],[38,3,40,3],[44,1,46,1],[44,2,46,2],[47,1,49,1],[35,6,37,6],[35,7,37,7],[32,1,34,1],[32,2,34,2],[13,7,15,7],[13,3,15,3],[13,4,15,4],[13,5,15,5],[13,6,15,6],[19,1,21,1],[19,2,21,2],[19,3,21,3],[19,4,21,4],[19,5,21,5],[19,6,21,6],[16,1,18,1],[16,2,18,2],[32,3,34,3],[32,4,34,4],[32,5,34,5],[32,6,34,6],[28,3,30,3],[28,4,30,4],[22,6,24,6],[1,9,1,13],[1,15,1,19],[1,21,1,27],[4,1,6,1],[4,2,6,2],[4,5,6,5],[4,3,6,3],[4,4,6,4],[7,1,9,1],[7,2,9,2],[7,7,9,7],[7,3,9,3],[7,4,9,4],[7,5,9,5],[7,6,9,6],[4,6,6,6],[4,7,6,7],[28,1,30,1],[28,2,30,2],[28,7,30,7],[22,7,24,7],[16,7,18,7],[13,1,15,1],[13,2,15,2],[10,1,12,1],[10,2,12,2],[28,5,30,5],[28,6,30,6],[22,3,24,3],[22,4,24,4],[22,5,24,5],[19,7,21,7],[16,3,18,3],[16,4,18,4],[16,5,18,5],[16,6,18,6],[10,3,12,3],[10,4,12,4],[10,5,12,5],[10,6,12,6],[10,7,12,7]]}
["Supplementary Table 15. Validation results. We report the results for the current study (GIANT), validation study (UK Biobank [UKBB]), and the combined GIANT + UKBB meta-analysys results for the smoking stratum, SNPadjSMK, SNPint, and SNPjoint models. The discovery approach is included in the App column (1-SNPadjSMK, 2-SNPjoint, 3-SNPint, 4-SNPscreen) and strata (C=Combined Men and Women, W=Women-only, M=Men-only)."]
[" ",{"$nulls":8},"Smokers",{"$nulls":5},"Non-Smokers",{"$nulls":5},"Main and Interaction Effects"]
["Stage","App","MARKERNAME","Chr","pos_hg19","Gene","Effect Allele","Other Allele",null,"N","EAF","BETA","SE","P",null,"N","EAF","BETA","SE","P",null,"N","EAF","BETAadjSmk","SEadjSmk","PadjSmk","Pint","Pjoint"]
["BMI"]
["GIANT","1:EC","rs2481665",1,62594677,"INADL","T","C",null,45695,0.56000000000000005,1.4999999999999999E-2,7.0000000000000001E-3,4.5999999999999999E-2,null,163758,0.56000000000000005,2.1000000000000001E-2,4.0000000000000001E-3,8.9000000000000003E-8,null,209453,0.56000000000000005,1.9E-2,3.0000000000000001E-3,3.5000000000000002E-8,0.4,6.7000000000000004E-8]
["UKBB",{"$nulls":8},14688,0.562249,1.178859E-2,1.2787438999999999E-2,0.35658685400000001,null,104956,0.562249,1.0408005E-2,4.3312100000000003E-3,1.6260075999999998E-2,null,119644,0.562249,1.0569240000000001E-2,4.1116269999999996E-3,1.0153021999999999E-2,0.91855212393395302,3.6435814974233302E-2]
["GIANT + UKBB",{"$nulls":8},60383,0.56054706311379032,1.4259551433006499E-2,6.1402088857190201E-3,2.0215522722617899E-2,null,268714,0.56087842852996128,1.61244262789648E-2,2.9385509246735901E-3,4.08347121681283E-8,null,329097,0.56081762931901535,1.6071011616219402E-2,2.4234784975670901E-3,3.3255840556680499E-11,0.78411661159088297,1.95304086912043E-8]
["GIANT","1,2","rs10929925",2,6155557,"SOX11","C","A",null,48147,0.54959999999999998,1.8700000000000001E-2,7.0000000000000001E-3,7.7999999999999996E-3,null,176920,0.54590000000000005,2.0400000000000001E-2,3.8E-3,8.3999999999999998E-8,null,225067,0.55000000000000004,0.02,3.3E-3,1.0999999999999999E-9,0.82,1.6000000000000001E-8]
["UKBB",{"$nulls":8},14688,0.57461300000000004,2.4404330000000001E-3,1.2902337E-2,0.84997789599999996,null,104956,0.57461300000000004,1.9802055999999998E-2,4.3680769999999997E-3,5.8100000000000003E-6,null,119644,0.57461300000000004,1.7619203E-2,4.1467600000000002E-3,2.1500000000000001E-5,0.202465965598879,3.3850568964542299E-5]
["GIANT + UKBB",{"$nulls":8},62835,0.55544691563619009,1.50024194853196E-2,6.1527987903096798E-3,1.47561887778507E-2,null,281876,0.55659123170472125,2.0142413888511099E-2,2.86695747245701E-3,2.1297929361181799E-12,null,344711,0.55854280186010896,1.9076862796088501E-2,2.58214629621587E-3,1.49068518534385E-13,0.44891660450736698,9.7828143873261197E-13]
["GIANT",1,"rs6794880",3,84451512,"SRRM1P2","A","G",null,39000,0.85009999999999997,2.5000000000000001E-2,1.0999999999999999E-2,2.3E-2,null,147968,0.84950000000000003,2.7199999999999998E-2,5.8999999999999999E-3,3.8999999999999999E-6,null,186968,0.85,2.81E-2,5.1000000000000004E-3,4.3000000000000001E-8,0.85,1.7999999999999999E-6]
["UKBB",{"$nulls":8},14688,0.84299999999999997,1.0481977E-2,1.7537666E-2,0.55005102699999997,null,104956,0.84299999999999997,1.8329426999999999E-2,5.9219939999999999E-3,1.9671720000000001E-3,null,119644,0.84299999999999997,1.481536E-2,5.6238850000000003E-3,8.4295020000000002E-3,0.11959228257043,6.9530660781739898E-3]
["GIANT + UKBB",{"$nulls":8},53688,0.84815757711220396,1.49822154267706E-2,9.3186657396853497E-3,0.107886872819733,null,252924,0.84680269171767009,2.2781216528785699E-2,4.1796843621053703E-3,5.02387489541429E-8,null,306612,0.84726850873416559,2.21051182923961E-2,3.77791206827991E-3,4.8819494317093896E-9,0.44508916699619,9.7225962780292503E-8]
["GIANT","1:EW","rs2173039",3,89142175,"EPHA3","C","G",null,23249,0.26,2.4E-2,1.0999999999999999E-2,3.1E-2,null,94693,0.26,3.2000000000000001E-2,6.0000000000000001E-3,8.9000000000000003E-8,null,117942,0.26,3.1E-2,5.0000000000000001E-3,7.3E-9,0.56999999999999995,6.5E-8]
["UKBB",{"$nulls":8},7163,0.253,1.4309799999999999E-2,2.0639600000000001E-2,0.49,null,55866,0.253,1.08658E-2,6.8269999999999997E-3,0.11,null,63029,0.253,1.1258799999999999E-2,6.4901000000000004E-3,8.3000000000000004E-2,0.87412418576406203,0.22158974685537]
["GIANT + UKBB",{"$nulls":8},30412,0.25835127581217937,2.1856436899515198E-2,9.7074026103509299E-3,2.43524536444048E-2,null,150559,0.25740259964532175,2.27898526302481E-2,4.5068207584962596E-3,4.2646826807301101E-7,null,180971,0.25756202374966153,2.3647203207441101E-2,3.9608728043626197E-3,2.36962782295973E-9,0.93050130687406496,2.2212566456547701E-7]
["GIANT","1:AW","rs12629427",3,89145340,"EPHA3","C","T",null,26237,0.25700000000000001,2.4799999999999999E-2,1.0800000000000001E-2,2.1000000000000001E-2,null,111724,0.25469999999999998,2.7799999999999998E-2,5.4999999999999997E-3,3.5999999999999999E-7,null,137961,0.26,2.6499999999999999E-2,4.8999999999999998E-3,4.8E-8,0.8,1.9999999999999999E-7]
["UKBB",{"$nulls":8},7163,0.24399999999999999,1.3717099999999999E-2,2.06263E-2,0.51,null,55866,0.254,1.1092899999999999E-2,6.8252E-3,0.1,null,63029,0.254,1.1392599999999999E-2,6.4879999999999998E-3,7.9000000000000001E-2,0.90386128117797204,0.21397223911847299]
["GIANT + UKBB",{"$nulls":8},33400,0.25421200598802396,2.2415297895170602E-2,9.5677912267811693E-3,1.9140301389164401E-2,null,167590,0.25446665552837283,2.12222607520277E-2,4.28255720409356E-3,7.2140317955714702E-7,null,200990,0.25811844370366688,2.10127695171425E-2,3.9101424401462399E-3,7.7045580899885804E-8,0.90938665883546099,2.9898513403479398E-7]
["GIANT",2,"rs13069244",3,180441172,"CCDC39","A","G",null,47957,7.9899999999999999E-2,6.0999999999999999E-2,1.4200000000000001E-2,1.8E-5,null,185819,7.4999999999999997E-2,3.0700000000000002E-2,7.7000000000000002E-3,6.6000000000000005E-5,null,233776,0.08,3.5099999999999999E-2,6.6E-3,1.1999999999999999E-7,4.5999999999999999E-2,3.5000000000000002E-8]
["UKBB",{"$nulls":8},14688,7.2999999999999954E-2,5.9762977000000002E-2,2.4390057E-2,1.4273689000000001E-2,null,104956,7.2999999999999954E-2,2.1135978E-2,8.2911530000000008E-3,1.0796401000000001E-2,null,119644,7.2999999999999954E-2,2.5880924999999999E-2,7.8667909999999997E-3,1.002244E-3,0.133757048020227,1.9280427425958299E-3]
["GIANT + UKBB",{"$nulls":8},62645,7.8282198100407041E-2,6.0686844120758997E-2,1.22716853927316E-2,7.6036920718443799E-7,null,290775,7.4278094746797335E-2,2.62710645023966E-2,5.6421460494581301E-3,3.2207021301170801E-6,null,353420,7.7630275592779116E-2,3.1291592083073E-2,5.0562165734316803E-3,6.0648362465429101E-10,1.0831996757959501E-2,9.5867745405884199E-11]
["GIANT",3,"rs336396",4,143062811,"INPP4B","T","C",null,35428,0.18379999999999999,6.3E-2,1.15E-2,4.8E-8,null,134218,0.1832,-5.8999999999999999E-3,6.1999999999999998E-3,0.34,null,169646,0.18,6.6E-3,5.4999999999999997E-3,0.23,2.0999999999999999E-8,1.9000000000000001E-7]
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["GIANT + UKBB",{"$nulls":8},27184,0.27,3.0000000000000001E-3,5.0000000000000001E-3,0.6,null,110262,0.26200000000000001,3.7999999999999999E-2,4.0000000000000001E-3,1.6E-18,null,137514,0.26400000000000001,4.1000000000000002E-2,4.0000000000000001E-3,3.5E-20,2.4999999999999999E-7,1.6000000000000001E-17]
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["GIANT + UKBB",{"$nulls":8},46965,0.65200000000000002,2.5000000000000001E-2,7.0000000000000001E-3,2.9999999999999997E-4,null,221920,0.65300000000000002,2.7E-2,5.0000000000000001E-3,1.6000000000000001E-8,null,269166,0.65200000000000002,2.5999999999999999E-2,3.0000000000000001E-3,1.2E-18,0.83,1.8E-10]
["GIANT","1:EC","rs589428",6,31848220,"EHMT2","G","T",null,35979,0.66400000000000003,6.0000000000000001E-3,4.0000000000000001E-3,0.12,null,126939,0.67,1.0999999999999999E-2,3.0000000000000001E-3,4.0999999999999999E-4,null,161392,0.66800000000000004,2.1999999999999999E-2,4.0000000000000001E-3,2.7999999999999999E-8,0.35,6.9999999999999999E-4]
["UKBB",{"$nulls":8},14684,0.63200000000000001,2.8000000000000001E-2,1.2E-2,2.1999999999999999E-2,null,104916,0.63200000000000001,2.8000000000000001E-2,4.0000000000000001E-3,8.3999999999999999E-10,null,119600,0.63200000000000001,2.7E-2,4.0000000000000001E-3,6.3999999999999999E-11,0.99,4.8999999999999996E-10]
["GIANT + UKBB",{"$nulls":8},50663,0.64800000000000002,8.0000000000000002E-3,4.0000000000000001E-3,2.9000000000000001E-2,null,231855,0.65100000000000002,1.6E-2,3.0000000000000001E-3,2.1E-10,null,280992,0.65,2.4E-2,3.0000000000000001E-3,1.1E-17,8.4000000000000005E-2,1.5999999999999999E-10]
["GIANT",4,"rs7766106",6,127455138,"RSPO3","T","C",null,39761,0.47899999999999998,7.0000000000000001E-3,4.0000000000000001E-3,7.9000000000000001E-2,null,148413,0.48399999999999999,2.1999999999999999E-2,3.0000000000000001E-3,2.1999999999999999E-15,null,186080,0.47699999999999998,3.6999999999999998E-2,3.0000000000000001E-3,3.7000000000000003E-27,9.7000000000000005E-4,3.8000000000000002E-15]
["UKBB",{"$nulls":8},14684,0.495,3.2000000000000001E-2,1.2E-2,6.1999999999999998E-3,null,104916,0.495,4.3999999999999997E-2,4.0000000000000001E-3,1.5E-24,null,119600,0.495,4.2999999999999997E-2,4.0000000000000001E-3,4.2999999999999999E-26,0.33,4.5000000000000001E-25]
["GIANT + UKBB",{"$nulls":8},54445,0.48699999999999999,8.9999999999999993E-3,4.0000000000000001E-3,1.2999999999999999E-2,null,253329,0.48899999999999999,2.8000000000000001E-2,2E-3,5.0000000000000003E-34,null,305680,0.48599999999999999,3.9E-2,3.0000000000000001E-3,4.4E-51,1.0000000000000001E-5,3.4000000000000001E-34]
["GIANT","2:EC","rs1856293",6,133480940,"EYA4","A","C",null,27688,0.52400000000000002,6.0000000000000001E-3,8.9999999999999993E-3,0.53,null,99743,0.51800000000000002,-2.8000000000000001E-2,5.0000000000000001E-3,9.1000000000000004E-9,null,127508,0.51900000000000002,-1.9E-2,4.0000000000000001E-3,6.4999999999999996E-6,5.4000000000000001E-4,4.6999999999999997E-8]
["UKBB",{"$nulls":8},14684,0.51400000000000001,-1.0999999999999999E-2,1.2E-2,0.35,null,104916,0.51400000000000001,-1.2999999999999999E-2,4.0000000000000001E-3,3.5999999999999999E-3,null,119600,0.51400000000000001,-1.2E-2,4.0000000000000001E-3,2.3E-3,0.89,9.2999999999999992E-3]
["GIANT + UKBB",{"$nulls":8},42372,0.51900000000000002,0,7.0000000000000001E-3,0.96,null,204659,0.51600000000000001,-0.02,3.0000000000000001E-3,1.9000000000000001E-9,null,247108,0.51700000000000002,-1.6E-2,3.0000000000000001E-3,9.5999999999999999E-8,1.2999999999999999E-2,1.4999999999999999E-8]
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["UKBB",{"$nulls":8},7161,0.47899999999999998,-3.0000000000000001E-3,1.6E-2,0.83,null,55845,0.47899999999999998,1.9E-2,6.0000000000000001E-3,1.4E-3,null,63006,0.47899999999999998,1.7000000000000001E-2,6.0000000000000001E-3,3.2000000000000002E-3,0.2,5.8999999999999999E-3]
["GIANT + UKBB",{"$nulls":8},27118,0.441,8.0000000000000002E-3,6.0000000000000001E-3,0.16,null,139334,0.46,1.4E-2,3.0000000000000001E-3,5.8999999999999996E-7,null,165570,0.48399999999999999,2.1999999999999999E-2,4.0000000000000001E-3,1.0999999999999999E-9,0.3,1.3999999999999999E-6]
["GIANT","4:EM","rs754133",12,54418920,"HOXC4-\nHOXC6","A","G",null,18192,0.39200000000000002,3.0000000000000001E-3,5.0000000000000001E-3,0.62,null,52944,0.34200000000000003,2.5999999999999999E-2,5.0000000000000001E-3,8.1999999999999998E-7,null,71812,0.36,3.4000000000000002E-2,6.0000000000000001E-3,3E-9,1.1000000000000001E-3,3.9999999999999998E-6]
["UKBB",{"$nulls":8},7523,0.36199999999999999,2.5999999999999999E-2,1.7000000000000001E-2,0.13,null,49071,0.36199999999999999,2.4E-2,7.0000000000000001E-3,2.7E-4,null,56594,0.36199999999999999,2.4E-2,6.0000000000000001E-3,7.7999999999999999E-5,0.9,4.0999999999999999E-4]
["GIANT + UKBB",{"$nulls":8},25715,0.377,4.0000000000000001E-3,5.0000000000000001E-3,0.37,null,102015,0.35199999999999998,2.5000000000000001E-2,4.0000000000000001E-3,7.5999999999999996E-10,null,128406,0.36099999999999999,0.03,4.0000000000000001E-3,2.0999999999999999E-12,9.7000000000000005E-4,4.0000000000000002E-9]
["GIANT","4:AM","rs2071449",12,54428011,"HOXC4-\nHOXC6","A","C",null,18144,0.40200000000000002,3.0000000000000001E-3,5.0000000000000001E-3,0.6,null,52724,0.35399999999999998,2.5999999999999999E-2,5.0000000000000001E-3,9.9999999999999995E-7,null,71571,0.36399999999999999,3.4000000000000002E-2,6.0000000000000001E-3,9.1000000000000004E-9,1.1000000000000001E-3,5.6999999999999996E-6]
["UKBB",{"$nulls":8},7523,0.36599999999999999,2.5999999999999999E-2,1.7000000000000001E-2,0.13,null,49071,0.36599999999999999,2.5000000000000001E-2,7.0000000000000001E-3,1.2999999999999999E-4,null,56594,0.36599999999999999,2.5000000000000001E-2,6.0000000000000001E-3,3.8999999999999999E-5,0.97,2.1000000000000001E-4]
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["GIANT","1:EC","rs17065323",13,44627788,"SMIM2","T","C",null,6602,7.0000000000000001E-3,0.154,0.11600000000000001,0.19,null,63366,8.0000000000000002E-3,-0.23,3.5999999999999997E-2,1.2E-10,null,86739,7.0000000000000001E-3,-0.18099999999999999,3.2000000000000001E-2,9.1999999999999997E-9,1.4E-3,3.9E-10]
["UKBB",{"$nulls":8},14684,4.0000000000000001E-3,6.0000000000000001E-3,0.107,0.96,null,104916,4.0000000000000001E-3,-9.0999999999999998E-2,0.04,2.3E-2,null,119600,4.0000000000000001E-3,-7.9000000000000001E-2,3.6999999999999998E-2,3.5999999999999997E-2,0.4,7.5999999999999998E-2]
["GIANT + UKBB",{"$nulls":8},21286,6.0000000000000001E-3,7.2999999999999995E-2,7.9000000000000001E-2,0.35,null,168282,6.0000000000000001E-3,-0.16800000000000001,2.7E-2,2.5000000000000002E-10,null,206339,6.0000000000000001E-3,-0.13900000000000001,2.4E-2,9.5999999999999999E-9,3.5999999999999999E-3,1.3000000000000001E-9]
["GIANT","4:AM","rs12608504",19,18389135,"JUND","A","G",null,19459,0.38900000000000001,6.0000000000000001E-3,5.0000000000000001E-3,0.26,null,60628,0.35799999999999998,2.5000000000000001E-2,5.0000000000000001E-3,4.9999999999999998E-7,null,80912,0.35699999999999998,3.2000000000000001E-2,5.0000000000000001E-3,4.6999999999999999E-9,5.4999999999999997E-3,1.7999999999999999E-6]
["UKBB",{"$nulls":8},7523,0.36599999999999999,2.9000000000000001E-2,1.7000000000000001E-2,9.1999999999999998E-2,null,49071,0.36599999999999999,1.9E-2,7.0000000000000001E-3,3.0999999999999999E-3,null,56594,0.36599999999999999,2.1000000000000001E-2,6.0000000000000001E-3,7.3999999999999999E-4,0.6,3.0000000000000001E-3]
["GIANT + UKBB",{"$nulls":8},26982,0.378,7.0000000000000001E-3,5.0000000000000001E-3,0.13,null,109699,0.36199999999999999,2.3E-2,4.0000000000000001E-3,6.8999999999999997E-9,null,137506,0.36199999999999999,2.7E-2,4.0000000000000001E-3,2.9E-11,1.2999999999999999E-2,1.6000000000000001E-8]

{"sheet":"ST 16. Genetic Risk Score","index":25,"n_rows":32,"n_cols":9,"rows_kept":32,"cut":false,"hidden":false,"merged":[[22,0,24,0],[25,0,27,0],[28,0,30,0],[2,0,4,0],[5,0,7,0],[8,0,10,0],[12,0,14,0],[15,0,17,0],[18,0,20,0]]}
["Supplementary Table 16. Genetic Risk Score (GRS) calculation in the combined KORA-S3 and KORA-S4 study.  "]
["SNPset","Modela","BetaGRS","PvalGRS","BetaSMK","PvalSMK","BetaGRSxSMK","PvalGRSxSMK","Multiple R2"]
["97 known","BMI~GRS",8.8469999999999993E-2,3.1299999999999998E-13,"-","-","-","-",1.532E-2]
[null,"BMI~GRS+SMK",8.8580000000000006E-2,2.8699999999999999E-13,-0.36221999999999999,4.5499999999999999E-2,"-","-",1.6469999999999999E-2]
[null,"BMI~GRS+SMK+SMK*GRS",7.9589999999999994E-2,2.6799999999999998E-9,-4.8559900000000003,8.6999999999999994E-2,4.9930000000000002E-2,0.113,1.719E-2]
["97 known + 6 novel","BMI~GRS",9.2590000000000006E-2,2.1900000000000001E-15,"-","-","-","-",1.8110000000000001E-2]
[null,"BMI~GRS+SMK",9.2689999999999995E-2,2.0000000000000002E-15,-0.36242000000000002,4.5100000000000001E-2,"-","-",1.9259999999999999E-2]
[null,"BMI~GRS+SMK+SMK*GRS",8.2849999999999993E-2,1.1800000000000001E-10,-5.5716599999999996,5.3199999999999997E-2,5.4820000000000001E-2,7.0099999999999996E-2,2.019E-2]
["97 known + 6 novel + 3 int","BMI~GRS",9.2240000000000003E-2,6.3900000000000003E-16,"-","-","-","-",1.8800000000000001E-2]
[null,"BMI~GRS+SMK",9.2249999999999999E-2,6.19E-16,-0.35696,4.8399999999999999E-2,"-","-",1.992E-2]
[null,"BMI~GRS+SMK+SMK*GRS",8.158E-2,8.6900000000000005E-11,-6.1302599999999998,3.3799999999999997E-2,5.9139999999999998E-2,4.5199999999999997E-2,2.1059999999999999E-2]
[]
["77 known","WCADJ~GRS",0.14954000000000001,"<2e-16","-","-","-","-",2.5850000000000001E-2]
[null,"WCADJ~GRS+SMK",0.14749999999999999,"<2e-16",0.83181000000000005,8.2999999999999998E-5,"-","-",3.023E-2]
[null,"WCADJ~GRS+SMK+SMK*GRS",0.15436,"<2e-16",3.5869900000000001,0.24299999999999999,-3.5610000000000003E-2,0.36899999999999999,3.0460000000000001E-2]
["77 known + 11 novel","WCADJ~GRS",0.14768000000000001,"<2e-16","-","-","-","-",2.9080000000000002E-2]
[null,"WCADJ~GRS+SMK",0.14571000000000001,"<2e-16",0.82426999999999995,9.3800000000000003E-5,"-","-",3.338E-2]
[null,"WCADJ~GRS+SMK+SMK*GRS",0.15179999999999999,"<2e-16",3.7002700000000002,0.27,-3.1669999999999997E-2,0.39,3.3579999999999999E-2]
["77 known + 11 novel + 2 int","WCADJ~GRS",0.14445,"<2e-16",null,"-","-","-",2.8320000000000001E-2]
[null,"WCADJ~GRS+SMK",0.14249999999999999,"<2e-16",0.82548999999999995,9.2200000000000005E-5,"-","-",3.2640000000000002E-2]
[null,"WCADJ~GRS+SMK+SMK*GRS",0.14907999999999999,"<2e-16",4.0443600000000002,0.24,-3.431E-2,0.34899999999999998,3.2890000000000003E-2]
[]
["66 known","WHRADJ~GRS",7.6880000000000004E-4,1.11E-7,"-","-","-","-",8.1650000000000004E-3]
[null,"WHRADJ~GRS+SMK",7.5429999999999996E-4,1.61E-7,1.3703699999999999E-2,5.6099999999999999E-11,"-","-",2.0490000000000001E-2]
[null,"WHRADJ~GRS+SMK+SMK*GRS",8.7850000000000005E-4,3.7100000000000001E-8,5.5400699999999997E-2,1.6899999999999998E-2,-6.6620000000000004E-4,7.0900000000000005E-2,2.1420000000000002E-2]
["66 known + 6 novel","WHRADJ~GRS",8.4290000000000005E-4,1.02E-9,"-","-","-","-",1.0789999999999999E-2]
[null,"WHRADJ~GRS+SMK",8.2939999999999999E-4,1.49E-9,1.36828E-2,5.6599999999999997E-11,"-","-",2.308E-2]
[null,"WHRADJ~GRS+SMK+SMK*GRS",9.1719999999999996E-4,1.81E-9,4.4958400000000003E-2,5.8500000000000003E-2,-4.6020000000000002E-4,0.18640000000000001,2.3570000000000001E-2]
["66 known + 6 novel + 7 int","WHRADJ~GRS",6.9680000000000002E-4,8.5799999999999997E-9,"-","-","-","-",9.5969999999999996E-3]
[null,"WHRADJ~GRS+SMK",6.7770000000000005E-4,1.7800000000000001E-8,1.35856E-2,8.01E-11,"-","-",2.1700000000000001E-2]
[null,"WHRADJ~GRS+SMK+SMK*GRS",7.3789999999999999E-4,3.0500000000000002E-8,3.75582E-2,0.1,-3.2650000000000002E-4,0.29199999999999998,2.2020000000000001E-2]
["a All outcome traits were adjusted for age, age2 and sex. Waist cirrcumferrence and waist-hip ration were additionally adjusted for BMI."]