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{"sheet":"SuppTable3","index":0,"n_rows":86,"n_cols":21,"rows_kept":86,"cut":false,"hidden":false,"merged":[[47,0,47,20],[0,9,0,17],[0,0,2,0],[0,1,2,1],[0,2,2,2],[0,3,2,3],[0,4,2,4],[0,5,2,5],[3,0,3,20],[1,15,1,17],[0,18,1,20],[1,9,1,10],[1,11,1,12],[1,13,1,14],[0,6,1,8]]}
["trait","rsid","Position b37","Non/coding allele","Effect allele frequency","Conditioned on","Stage 1 discovery",null,null,"Stage 2",{"$nulls":8},"Stage 1 + 2"]
[{"$nulls":9},"UKB",null,"SpiroMeta",null,"UKHLS",null,"Meta"]
[{"$nulls":6},"beta","se","P","beta","se","beta","se","beta","se","beta","se","Meta P","beta","se","Meta P"]
["43 novel variants with P < 5x10-8 following Stage 1 + 2 meta-analysis"]
["FEV1/FVC","rs17513135","1:40035686","C/T",0.23150000000000001," -",-4.7E-2,8.0000000000000002E-3,1.25E-9,-3.4000000000000002E-2,8.0000000000000002E-3,-2.5000000000000001E-2,8.9999999999999993E-3,-0.03,0.02,-3.3000000000000002E-2,6.0000000000000001E-3,1.1700000000000001E-8,-3.7999999999999999E-2,5.0000000000000001E-3,2.3100000000000001E-16]
["FEV1/FVC","rs1192404","1:92068967","A/G",0.16209999999999999,"rs12140637",-4.5999999999999999E-2,8.9999999999999993E-3,1.1000000000000001E-7,-4.7E-2,8.9999999999999993E-3,-4.5999999999999999E-2,0.01,-3.3000000000000002E-2,2.3E-2,-0.05,7.0000000000000001E-3,9.3100000000000002E-14,-4.8000000000000001E-2,5.0000000000000001E-3,6.09E-20]
["FEV1/FVC","rs12140637","1:92374517","C/T",0.313," -",-3.5999999999999997E-2,7.0000000000000001E-3,3.4900000000000001E-7,-1.4E-2,7.0000000000000001E-3,-1.9E-2,8.0000000000000002E-3,-4.2000000000000003E-2,1.7999999999999999E-2,-0.02,5.0000000000000001E-3,1.46E-4,-2.5999999999999999E-2,4.0000000000000001E-3,1.1800000000000001E-9]
["FVC","rs200154334","1:118862070","AT/-",0.24790000000000001," -",5.3999999999999999E-2,8.0000000000000002E-3,9.6999999999999995E-12,2.5000000000000001E-2,8.0000000000000002E-3,2.3E-2,8.9999999999999993E-3,1E-3,0.02,2.4E-2,6.0000000000000001E-3,1.6900000000000001E-5,3.4000000000000002E-2,5.0000000000000001E-3,8.2000000000000004E-14]
["FEV1/FVC","rs6688537","1:239850588","C/A",0.50600000000000001," -",-3.6999999999999998E-2,7.0000000000000001E-3,2.7400000000000001E-8,-4.2000000000000003E-2,6.0000000000000001E-3,-2.3E-2,8.0000000000000002E-3,-4.9000000000000002E-2,1.7000000000000001E-2,-3.9E-2,5.0000000000000001E-3,4.0499999999999999E-15,-3.7999999999999999E-2,4.0000000000000001E-3,6.7200000000000003E-22]
["FEV1/FVC","rs61332075","2:239316560","G/C",0.123," -",0.06,0.01,2.93E-9,2.5000000000000001E-2,0.01,2.1000000000000001E-2,1.2E-2,2.9000000000000001E-2,2.5000000000000001E-2,2.5999999999999999E-2,7.0000000000000001E-3,5.1099999999999995E-4,3.7999999999999999E-2,6.0000000000000001E-3,2.55E-10]
["FEV1/FVC","rs1458979","3:55150677","A/G",0.50109999999999999," -",-3.5000000000000003E-2,7.0000000000000001E-3,1.5200000000000001E-7,-2.1000000000000001E-2,6.0000000000000001E-3,-0.01,8.0000000000000002E-3,-3.1E-2,1.7000000000000001E-2,-1.9E-2,5.0000000000000001E-3,1.07E-4,-2.5000000000000001E-2,4.0000000000000001E-3,4.4200000000000002E-10]
["FVC","rs1490265","3:67452043","C/A",0.70789999999999997," -",3.9E-2,7.0000000000000001E-3,1.03E-7,2.1999999999999999E-2,7.0000000000000001E-3,8.0000000000000002E-3,8.0000000000000002E-3,3.5999999999999997E-2,1.7999999999999999E-2,1.9E-2,5.0000000000000001E-3,3.2699999999999998E-4,2.5999999999999999E-2,4.0000000000000001E-3,1.5799999999999999E-9]
["FEV1/FVC","rs2811415","3:127991527","A/G",0.84040000000000004," -",-5.7000000000000002E-2,8.9999999999999993E-3,2.6400000000000002E-10,-1.7000000000000001E-2,8.9999999999999993E-3,-2.3E-2,0.01,-4.1000000000000002E-2,2.1999999999999999E-2,-2.3E-2,7.0000000000000001E-3,4.5300000000000001E-4,-3.5000000000000003E-2,5.0000000000000001E-3,5.5200000000000001E-11]
["FEV1/FVC","rs56341938*","3:168715808","A/G",0.51339999999999997," -",3.4000000000000002E-2,7.0000000000000001E-3,3.3799999999999998E-7,3.6999999999999998E-2,6.0000000000000001E-3,1.2999999999999999E-2,8.0000000000000002E-3,"-","-",2.7E-2,5.0000000000000001E-3,1.9700000000000001E-8,2.9000000000000001E-2,4.0000000000000001E-3,4.5199999999999999E-14]
["FEV1/FVC","rs13110699","4:89815695","T/G",0.82509999999999994,"rs2045517",-4.4999999999999998E-2,8.0000000000000002E-3,1.29E-7,-3.6999999999999998E-2,8.0000000000000002E-3,-0.03,8.9999999999999993E-3,-1.4E-2,2.4E-2,-3.5000000000000003E-2,6.0000000000000001E-3,7.8000000000000004E-9,-3.7999999999999999E-2,5.0000000000000001E-3,7.8600000000000007E-15]
["FVC","rs91731","5:33334312","C/A",0.90529999999999999," -",-7.0000000000000007E-2,1.0999999999999999E-2,8.0999999999999999E-10,-3.1E-2,1.0999999999999999E-2,-4.7E-2,1.2999999999999999E-2,0,2.8000000000000001E-2,-3.7999999999999999E-2,8.0000000000000002E-3,7.8800000000000008E-6,-4.9000000000000002E-2,7.0000000000000001E-3,4.3099999999999998E-13]
["FEV1/FVC","rs1551943","5:52195033","G/A",0.2301," -",-5.1999999999999998E-2,8.0000000000000002E-3,3.12E-11,-4.1000000000000002E-2,8.0000000000000002E-3,-1.9E-2,8.9999999999999993E-3,-3.1E-2,0.02,-3.5000000000000003E-2,6.0000000000000001E-3,2.3499999999999999E-9,-4.1000000000000002E-2,5.0000000000000001E-3,1.9200000000000002E-18]
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["FEV1/FVC","rs7713065","5:131788334","A/C",0.73670000000000002," -",3.9E-2,7.0000000000000001E-3,2.2100000000000001E-7,2.9000000000000001E-2,7.0000000000000001E-3,1.4E-2,8.0000000000000002E-3,1.7000000000000001E-2,1.9E-2,2.4E-2,5.0000000000000001E-3,8.2900000000000002E-6,2.9000000000000001E-2,4.0000000000000001E-3,2.7699999999999999E-11]
["FEV1","rs3839234","5:148596693","G/-",0.47010000000000002," -",-3.7999999999999999E-2,7.0000000000000001E-3,8.8699999999999994E-9,-2.3E-2,6.0000000000000001E-3,-1.4E-2,8.0000000000000002E-3,1E-3,1.7000000000000001E-2,-1.9E-2,5.0000000000000001E-3,7.7100000000000004E-5,-2.5999999999999999E-2,4.0000000000000001E-3,4.4800000000000003E-11]
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["FEV1/FVC","rs28986170","6:31556155","-/AA",7.5200000000000003E-2,"rs2070600 rs9272528*",7.4999999999999997E-2,1.2999999999999999E-2,2.3000000000000001E-8,3.4000000000000002E-2,1.4E-2,"-","-",9.6000000000000002E-2,3.5999999999999997E-2,4.8000000000000001E-2,1.4E-2,6.4899999999999995E-4,6.3E-2,0.01,1.56E-10]
["FEV1","rs114229351","6:32648418","T/C",0.17530000000000001,"rs34864796",-4.5999999999999999E-2,8.9999999999999993E-3,1.15E-7,-2.5999999999999999E-2,8.0000000000000002E-3,"-","-",-4.4999999999999998E-2,2.5999999999999999E-2,-0.03,8.0000000000000002E-3,1.7799999999999999E-4,-3.6999999999999998E-2,6.0000000000000001E-3,2.1199999999999999E-10]
["FEV1/FVC","rs141651520","6:73670095","TTCTAT/-",0.20100000000000001," -",4.2000000000000003E-2,8.0000000000000002E-3,3.3799999999999998E-7,4.9000000000000002E-2,8.0000000000000002E-3,2.5999999999999999E-2,8.9999999999999993E-3,2.5000000000000001E-2,0.02,4.2000000000000003E-2,6.0000000000000001E-3,5.4900000000000002E-12,4.2000000000000003E-2,5.0000000000000001E-3,9.9300000000000003E-18]
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["FEV1","rs12698403","7:156127246","G/A",0.44359999999999999," -",-3.5999999999999997E-2,7.0000000000000001E-3,7.4299999999999997E-8,-2.5000000000000001E-2,6.0000000000000001E-3,-2.5000000000000001E-2,8.0000000000000002E-3,-1.2E-2,1.7000000000000001E-2,-2.5999999999999999E-2,5.0000000000000001E-3,1.43E-7,-2.9000000000000001E-2,4.0000000000000001E-3,1.1099999999999999E-13]
["FEV1","rs7872188","9:4124377","C/T",0.4017," -",-3.7999999999999999E-2,7.0000000000000001E-3,1.7999999999999999E-8,-1.9E-2,7.0000000000000001E-3,-0.02,8.0000000000000002E-3,5.0000000000000001E-3,1.7000000000000001E-2,-1.9E-2,5.0000000000000001E-3,1.4100000000000001E-4,-2.5999999999999999E-2,4.0000000000000001E-3,1.5899999999999999E-10]
["FVC","rs10870202","9:139257411","T/C",0.50009999999999999,"rs10858246",-3.3000000000000002E-2,6.0000000000000001E-3,3.2500000000000001E-7,-1.6E-2,6.0000000000000001E-3,-1.7000000000000001E-2,8.0000000000000002E-3,-2.7E-2,1.7000000000000001E-2,-1.9E-2,5.0000000000000001E-3,1.54E-4,-2.4E-2,4.0000000000000001E-3,9.3200000000000009E-10]
["FEV1/FVC","rs3847402","10:30267810","G/A",0.40570000000000001," -",-3.5999999999999997E-2,7.0000000000000001E-3,9.9999999999999995E-8,-1.7000000000000001E-2,7.0000000000000001E-3,-2.7E-2,8.0000000000000002E-3,-7.0000000000000001E-3,1.7000000000000001E-2,-2.1000000000000001E-2,5.0000000000000001E-3,3.8399999999999998E-5,-2.7E-2,4.0000000000000001E-3,7.7200000000000002E-11]
["FVC","rs7095607","10:69957350","G/A",0.49519999999999997," -",-3.6999999999999998E-2,7.0000000000000001E-3,3.9300000000000001E-8,-2.1000000000000001E-2,6.0000000000000001E-3,-2.9000000000000001E-2,8.0000000000000002E-3,-0.03,1.7000000000000001E-2,-2.7E-2,5.0000000000000001E-3,2.2600000000000001E-8,-3.1E-2,4.0000000000000001E-3,8.6699999999999993E-15]
["FEV1","rs2509961","11:62310909","T/C",0.3821," -",3.5999999999999997E-2,7.0000000000000001E-3,1.68E-7,0.03,7.0000000000000001E-3,1.7000000000000001E-2,8.0000000000000002E-3,2.5000000000000001E-2,1.7000000000000001E-2,2.7E-2,5.0000000000000001E-3,1.0700000000000001E-7,0.03,4.0000000000000001E-3,1.49E-13]
["FEV1","rs145729347*","11:86442733","G/C",0.15079999999999999," -",-5.6000000000000001E-2,8.9999999999999993E-3,1.67E-9,-0.02,8.9999999999999993E-3,-1.6E-2,0.01," -"," -",-1.7999999999999999E-2,7.0000000000000001E-3,5.3600000000000002E-3,-3.1E-2,5.0000000000000001E-3,8.5799999999999997E-9]
["FEV1","rs567508","11:126008910","G/A",0.84960000000000002," -",0.05,8.9999999999999993E-3,1.11E-7,2.9000000000000001E-2,8.9999999999999993E-3,1.2999999999999999E-2,0.01,5.2999999999999999E-2,2.4E-2,2.5999999999999999E-2,7.0000000000000001E-3,1.08E-4,3.4000000000000002E-2,5.0000000000000001E-3,4.7700000000000001E-10]
["FEV1","rs1494502","12:65824670","A/G",0.36199999999999999," -",3.5999999999999997E-2,7.0000000000000001E-3,2.72E-7,0.02,7.0000000000000001E-3,1.2E-2,8.0000000000000002E-3,0.03,1.7000000000000001E-2,1.9E-2,5.0000000000000001E-3,1.3300000000000001E-4,2.5000000000000001E-2,4.0000000000000001E-3,9.7999999999999992E-10]
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["FVC","rs6140050","20:6632901","C/A",0.63339999999999996," -",0.04,7.0000000000000001E-3,5.9500000000000003E-9,2.5999999999999999E-2,7.0000000000000001E-3,2.8000000000000001E-2,8.0000000000000002E-3,-1.0999999999999999E-2,1.7000000000000001E-2,2.5999999999999999E-2,5.0000000000000001E-3,5.2300000000000001E-7,3.1E-2,4.0000000000000001E-3,6.3899999999999998E-14]
["FEV1","rs72448466","20:62363640","GT/-",0.67279999999999995," -",-3.7999999999999999E-2,7.0000000000000001E-3,1.09E-7,-0.02,7.0000000000000001E-3,-2.9000000000000001E-2,8.0000000000000002E-3,-3.2000000000000001E-2,1.7000000000000001E-2,-2.7E-2,5.0000000000000001E-3,3.6800000000000001E-7,-0.03,4.0000000000000001E-3,4.3099999999999998E-13]
["FEV1","rs11704827","22:18450287","A/T",0.23139999999999999," -",4.9000000000000002E-2,8.0000000000000002E-3,6.0799999999999997E-10,2.1000000000000001E-2,8.0000000000000002E-3,2.1000000000000001E-2,8.9999999999999993E-3,4.7E-2,0.02,2.5000000000000001E-2,6.0000000000000001E-3,1.4399999999999999E-5,3.3000000000000002E-2,5.0000000000000001E-3,8.3199999999999999E-13]
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["38 variants with P > 5x10-8 following Stage 1 + 2 meta-analysis"]
["FEV1/FVC","rs115523263","1:74346917","A/G",2.0000000000000001E-4," -",1.423,0.29299999999999998,1.2500000000000001E-6,"-","-","-","-","-","-","-","-","-",1.423,0.29299999999999998,1.2500000000000001E-6]
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["FEV1/FVC","rs114718931","2:116817626","G/A",5.1999999999999998E-3," -",0.26100000000000001,4.9000000000000002E-2,9.3400000000000003E-8,4.2000000000000003E-2,0.05,"-","-","-","-",4.2000000000000003E-2,0.05,0.39400000000000002,0.153,3.5000000000000003E-2,1.0699999999999999E-5]
["FEV1","rs35337335","2:136821878","C/-",0.755," -",-4.3999999999999997E-2,8.0000000000000002E-3,1.51E-8,-1.6E-2,7.0000000000000001E-3,-2E-3,8.9999999999999993E-3,-1.2E-2,1.9E-2,-1.2E-2,6.0000000000000001E-3,3.78E-2,-2.3E-2,5.0000000000000001E-3,4.7100000000000002E-7]
["FEV1/FVC","rs117946497","2:239716129","A/G",4.0000000000000002E-4,"rs61332075",0.59099999999999997,0.21199999999999999,5.3200000000000001E-3,-0.249,0.45500000000000002,"-","-","-","-",-0.249,0.45500000000000002,0.58399999999999996,0.441,0.192,2.18E-2]
["FEV1","rs115896660","2:242124398","G/A",2.0000000000000001E-4," -",-1.56,0.31,4.9900000000000001E-7,0.53900000000000003,0.29099999999999998,"-","-","-","-",0.53900000000000003,0.29099999999999998,6.3600000000000004E-2,-0.441,0.21199999999999999,3.7499999999999999E-2]
["FEV1/FVC","rs76798021","3:53734195","A/T",0.2142," -",-4.2000000000000003E-2,8.0000000000000002E-3,3.1800000000000002E-7,-1.7000000000000001E-2,8.0000000000000002E-3,-2E-3,8.9999999999999993E-3,-1.9E-2,0.02,-1.2999999999999999E-2,6.0000000000000001E-3,3.56E-2,-2.3E-2,5.0000000000000001E-3,2.39E-6]
["FVC","rs73874337","3:157936081","A/G",2.0000000000000001E-4,"rs1595029",2.2879999999999998,0.44400000000000001,2.5899999999999998E-7,0.316,0.187,"-","-","-","-",0.316,0.187,9.0999999999999998E-2,0.61199999999999999,0.17199999999999999,3.77E-4]
["FEV1","3:170245045","3:170245045","T/C",0.99990000000000001,"rs1344555",-3.1019999999999999,0.53100000000000003,5.3199999999999998E-9,"-","-","-","-","-","-","-","-"," -","-","-","-"]
["FEV1","5:64306455","5:64306455","T/C",0.99939999999999996," -",-0.86099999999999999,0.17100000000000001,4.9100000000000004E-7,-4.4999999999999998E-2,0.158,"-","-",0.24099999999999999,0.51500000000000001,-2.1999999999999999E-2,0.156,0.89,-0.40300000000000002,0.115,4.7600000000000002E-4]
["FEV1/FVC","rs1501911","5:98342868","T/A",0.61409999999999998," -",3.5000000000000003E-2,7.0000000000000001E-3,2.03E-7,1.4999999999999999E-2,7.0000000000000001E-3,1.2E-2,8.0000000000000002E-3,8.9999999999999993E-3,1.7000000000000001E-2,1.4999999999999999E-2,5.0000000000000001E-3,3.9100000000000003E-3,2.1999999999999999E-2,4.0000000000000001E-3,5.8500000000000001E-8]
["FEV1/FVC","rs141865554","5:99170686","C/T",1E-4,"rs1501911",4.4489999999999998,0.83,8.2700000000000006E-8,-0.36399999999999999,0.40699999999999997,"-","-","-","-",-0.36399999999999999,0.40699999999999997,0.371,0.56799999999999995,0.36499999999999999,0.12]
["FEV1","rs1800888","5:148206885","C/T",1.52E-2,"rs7715901",-0.13600000000000001,2.5999999999999999E-2,1.74E-7,-3.2000000000000001E-2,2.5999999999999999E-2,-0.114,3.6999999999999998E-2,1.2E-2,7.0000000000000007E-2,-5.7000000000000002E-2,2.1000000000000001E-2,6.9300000000000004E-3,-8.7999999999999995E-2,1.6E-2,7.1200000000000002E-8]
["FVC","rs4921269","5:158369472","A/C",0.61240000000000006," -",-3.7999999999999999E-2,7.0000000000000001E-3,2.0899999999999999E-8,-6.0000000000000001E-3,7.0000000000000001E-3,-1.2E-2,8.0000000000000002E-3,-6.0000000000000001E-3,1.7000000000000001E-2,-8.9999999999999993E-3,5.0000000000000001E-3,7.0999999999999994E-2,-1.9E-2,4.0000000000000001E-3,1.9300000000000002E-6]
["FEV1","rs9350191","6:19842661","C/T",0.84740000000000004," -",-4.9000000000000002E-2,8.9999999999999993E-3,9.9799999999999994E-8,0,8.9999999999999993E-3,-3.0000000000000001E-3,1.2999999999999999E-2,-4.4999999999999998E-2,2.5000000000000001E-2,-5.0000000000000001E-3,7.0000000000000001E-3,0.53600000000000003,-2.1999999999999999E-2,6.0000000000000001E-3,1.47E-4]
["FEV1","rs35879035","7:139780806","CCTG/-",6.6400000000000001E-2," -",8.4000000000000005E-2,1.7000000000000001E-2,4.9500000000000003E-7,0,0.02,7.0000000000000001E-3,8.9999999999999993E-3,0.02,4.3999999999999997E-2,7.0000000000000001E-3,8.0000000000000002E-3,0.39500000000000002,2.1999999999999999E-2,7.0000000000000001E-3,2.9499999999999999E-3]
["FEV1","8:42939683","8:42939683","-/ATG",0.99860000000000004," -",-0.56299999999999994,0.109,2.1199999999999999E-7,-6.7000000000000004E-2,8.7999999999999995E-2,"-","-","-","-",-6.7000000000000004E-2,8.7999999999999995E-2,0.44500000000000001,-0.26500000000000001,6.8000000000000005E-2,1.11E-4]
["FEV1/FVC","rs28540589","8:130116850","A/T",9.0399999999999994E-2," -",6.0999999999999999E-2,1.2E-2,1.37E-7,6.0000000000000001E-3,1.0999999999999999E-2,6.0000000000000001E-3,1.2999999999999999E-2,7.8E-2,2.8000000000000001E-2,1.2999999999999999E-2,8.0000000000000002E-3,0.13300000000000001,2.9000000000000001E-2,7.0000000000000001E-3,1.6200000000000001E-5]
["FEV1","rs545321445","9:104506708","T/A",0.99929999999999997," -",0.81299999999999994,0.161,4.63E-7,-9.6000000000000002E-2,0.10199999999999999,"-","-",-0.56100000000000005,0.40400000000000003,-0.13700000000000001,0.104,0.188,0.14199999999999999,8.6999999999999994E-2,0.104]
["FEV1","9:114030331","9:114030331","T/G",0.99970000000000003," -",-1.206,0.23499999999999999,2.8500000000000002E-7,8.9999999999999993E-3,0.22900000000000001,"-","-",-0.19,0.34200000000000003,-8.3000000000000004E-2,0.24,0.72799999999999998,-0.65600000000000003,0.16800000000000001,9.3200000000000002E-5]
["FEV1","10:1777320","10:1777320","T/C",0.99990000000000001,"rs11251156",4.7450000000000001,0.76800000000000002,6.5600000000000001E-10,8.1000000000000003E-2,0.33900000000000002,"-","-",0.26400000000000001,0.503,0.18,0.32100000000000001,0.57499999999999996,0.85699999999999998,0.29599999999999999,3.7699999999999999E-3]
["FEV1","rs11251156","10:2357720","A/G",1E-4," -",-1.94,0.36899999999999999,1.49E-7,0.23599999999999999,0.26800000000000002,"-","-","-","-",0.23599999999999999,0.26800000000000002,0.378,-0.51500000000000001,0.217,1.77E-2]
["FEV1","rs2482826","10:30467178","C/G",0.69869999999999999," -",-3.9E-2,7.0000000000000001E-3,9.9999999999999995E-8,-1.7999999999999999E-2,7.0000000000000001E-3,-1E-3,8.9999999999999993E-3,2E-3,1.7999999999999999E-2,-1.0999999999999999E-2,5.0000000000000001E-3,4.8000000000000001E-2,-2.1000000000000001E-2,4.0000000000000001E-3,1.9199999999999998E-6]
["FEV1/FVC","rs200528172","10:32461174","AG/-",0.79800000000000004," -",4.7E-2,8.9999999999999993E-3,5.8700000000000003E-8,1.4E-2,7.0000000000000001E-3,6.0000000000000001E-3,0.01,-3.0000000000000001E-3,2.1999999999999999E-2,1.2E-2,6.0000000000000001E-3,4.4699999999999997E-2,2.1999999999999999E-2,5.0000000000000001E-3,2.8399999999999999E-6]
["FVC","rs7914926","10:80930698","A/G",0.42830000000000001," -",3.5999999999999997E-2,7.0000000000000001E-3,1.36E-7,0.01,6.0000000000000001E-3,1.4999999999999999E-2,8.0000000000000002E-3,1E-3,1.7000000000000001E-2,1.2E-2,5.0000000000000001E-3,1.21E-2,2.1000000000000001E-2,4.0000000000000001E-3,2.7799999999999997E-7]
["FEV1/FVC","rs61860558","10:81318242","C/T",0.31740000000000002," -",-3.6999999999999998E-2,7.0000000000000001E-3,2.6300000000000001E-7,-1.2999999999999999E-2,7.0000000000000001E-3,"-","-",-3.4000000000000002E-2,1.9E-2,-1.7000000000000001E-2,7.0000000000000001E-3,1.2699999999999999E-2,-2.7E-2,5.0000000000000001E-3,8.0799999999999996E-8]
["FEV1","rs11198956","10:121236966","G/A",1.67E-2," -",0.14899999999999999,2.8000000000000001E-2,6.9899999999999997E-8,3.0000000000000001E-3,2.8000000000000001E-2,"-","-",0.111,7.8E-2,1.6E-2,2.7E-2,0.54700000000000004,8.2000000000000003E-2,1.9E-2,2.41E-5]
["FEV1/FVC","12:48035029","12:48035029","A/G",0.99990000000000001," -",1.8879999999999999,0.35599999999999998,1.1600000000000001E-7,"-","-","-","-","-","-","-","-","-","-","-","-"]
["FEV1/FVC","rs143491968","12:111220970","C/T",1.2699999999999999E-2," -",-0.16400000000000001,3.2000000000000001E-2,4.1199999999999998E-7,-4.5999999999999999E-2,0.03," -"," -",0.1,0.1,-3.6999999999999998E-2,0.03,0.224,-9.6000000000000002E-2,2.1999999999999999E-2,1.4E-5]
["FVC","rs112808000","12:111629999","C/T",1E-4," -",-2.327,0.42199999999999999,3.4800000000000001E-8,-0.122,0.219," -"," -"," -"," -",-0.122,0.219,0.57699999999999996,-0.58899999999999997,0.19400000000000001,2.4099999999999998E-3]
["FEV1/FVC","rs17294280","15:67468285","A/G",0.25769999999999998," -",-4.1000000000000002E-2,8.0000000000000002E-3,1.73E-7,-1.6E-2,8.0000000000000002E-3,-1.4999999999999999E-2,0.01,7.0000000000000001E-3,0.02,-1.4999999999999999E-2,6.0000000000000001E-3,1.32E-2,-2.4E-2,5.0000000000000001E-3,2.8700000000000002E-7]
["FEV1/FVC","rs10083577","15:71709070","G/A",9.3600000000000003E-2,"rs10851839 rs12591467",5.8999999999999997E-2,1.2E-2,4.39E-7," -"," -"," -"," -",3.0000000000000001E-3,0.03,1,0.51,5.0099999999999999E-2,5.8999999999999997E-2,1.2E-2,3.4900000000000001E-7]
["FEV1","rs3169315*","16:69720964","G/A",0.18890000000000001," -",-3.5999999999999997E-2,8.0000000000000002E-3,2.6699999999999998E-5,-1.0999999999999999E-2,8.0000000000000002E-3,-1.2E-2,0.01," -"," -",-1.0999999999999999E-2,6.0000000000000001E-3,6.3700000000000007E-2,-0.02,5.0000000000000001E-3,7.1000000000000005E-5]
["FVC","rs184983073","16:74300020","G/A",5.0999999999999997E-2," -",8.6999999999999994E-2,1.6E-2,8.0799999999999996E-8,6.0000000000000001E-3,1.0999999999999999E-2,-1.4E-2,1.7999999999999999E-2,1.2E-2,4.1000000000000002E-2,1E-3,0.01,0.88700000000000001,2.4E-2,8.0000000000000002E-3,4.1900000000000001E-3]
["FEV1/FVC","rs2721854","17:12245499","G/A",0.35949999999999999," -",-3.6999999999999998E-2,7.0000000000000001E-3,1.4700000000000001E-7,-8.9999999999999993E-3,7.0000000000000001E-3,4.0000000000000001E-3,8.0000000000000002E-3,-3.2000000000000001E-2,1.7000000000000001E-2,-6.0000000000000001E-3,5.0000000000000001E-3,0.22,-1.7000000000000001E-2,4.0000000000000001E-3,3.7599999999999999E-5]
["FEV1","rs187905018","17:36932797","T/G",2.2000000000000001E-3," -",-0.41099999999999998,8.2000000000000003E-2,4.8800000000000003E-7,-4.9000000000000002E-2,6.4000000000000001E-2," -"," -",1.4999999999999999E-2,0.191,-4.7E-2,6.4000000000000001E-2,0.46200000000000002,-0.186,0.05,2.2800000000000001E-4]
["FEV1","rs11650776","17:37641402","G/A",0.69750000000000001," -",4.7E-2,7.0000000000000001E-3,2.2699999999999999E-10,7.0000000000000001E-3,7.0000000000000001E-3," -"," -",8.0000000000000002E-3,1.9E-2,8.9999999999999993E-3,7.0000000000000001E-3,0.24,2.7E-2,5.0000000000000001E-3,1.3799999999999999E-7]

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["a) 43 novel signals"]
["Trait","rsid","Position (b37)","Gene","Non/coded allele","Effect allele frequency","Conditioned on",null,"FEV1",null,null,"FVC",null,null,"FEV1/FVC"]
[{"$nulls":7},"beta","se","p","beta","se","p","beta","se","p"]
["FEV1/FVC","rs17513135","1:40035686","LOC101929516 (intron)","C/T",0.23139999999999999,"-",-2.5999999999999999E-2,8.0000000000000002E-3,8.8599999999999996E-4,-1.0999999999999999E-2,8.0000000000000002E-3,0.152,-4.7E-2,8.0000000000000002E-3,1.26E-9]
["FEV1/FVC","rs1192404","1:92068967","CDC7/TGFBR3","A/G",0.16209999999999999,"rs12140637",-8.0000000000000002E-3,8.9999999999999993E-3,0.375,1.0999999999999999E-2,8.9999999999999993E-3,0.189,-4.5999999999999999E-2,8.9999999999999993E-3,1.1000000000000001E-7]
["FEV1/FVC","rs12140637","1:92374517","TGFBR3/BRDT2","C/T",0.313,"-",-4.0000000000000001E-3,7.0000000000000001E-3,0.55500000000000005,1.0999999999999999E-2,7.0000000000000001E-3,0.13,-3.5999999999999997E-2,7.0000000000000001E-3,3.4999999999999998E-7]
["FVC","rs200154334","1:118862070","SPAG17/TBX15","AT/-",0.24790000000000001,"-",4.9000000000000002E-2,8.0000000000000002E-3,7.1100000000000003E-10,5.3999999999999999E-2,8.0000000000000002E-3,9.7400000000000001E-12,0.01,8.0000000000000002E-3,0.189]
["FEV1/FVC","rs6688537","1:239850588","CHRM3 (intron)","C/A",0.50600000000000001,"-",-2.5999999999999999E-2,7.0000000000000001E-3,1.13E-4,-1.4999999999999999E-2,7.0000000000000001E-3,2.9000000000000001E-2,-3.6999999999999998E-2,7.0000000000000001E-3,2.7400000000000001E-8]
["FEV1/FVC","rs61332075","2:239316560","TRAF3IP1/ASB1","G/C",0.1229,"-",3.5000000000000003E-2,0.01,5.8500000000000002E-4,1.7000000000000001E-2,0.01,0.10100000000000001,0.06,0.01,2.93E-9]
["FEV1/FVC","rs1458979","3:55150677","CACNA2D3/WNT5A","A/G",0.501,"-",-0.03,7.0000000000000001E-3,8.0900000000000005E-6,-2.1000000000000001E-2,7.0000000000000001E-3,1.66E-3,-3.5000000000000003E-2,7.0000000000000001E-3,1.5200000000000001E-7]
["FVC","rs1490265","3:67452043","SUCLG2 (intron)","C/A",0.70799999999999996,"-",3.7999999999999999E-2,7.0000000000000001E-3,1.8199999999999999E-7,3.9E-2,7.0000000000000001E-3,1.03E-7,1.4E-2,7.0000000000000001E-3,6.1100000000000002E-2]
["FEV1/FVC","rs2811415","3:127991527","EEFSEC (intron)","A/G",0.84050000000000002,"-",-3.2000000000000001E-2,8.9999999999999993E-3,4.2700000000000002E-4,-1.0999999999999999E-2,8.9999999999999993E-3,0.23200000000000001,-5.7000000000000002E-2,8.9999999999999993E-3,2.6400000000000002E-10]
["FEV1/FVC","esv2660202","3:168738454","LOC100507661/MECOM","382bp/-",0.50829999999999997,"-",3.1E-2,7.0000000000000001E-3,2.2699999999999999E-6,0.02,7.0000000000000001E-3,2.99E-3,3.5000000000000003E-2,7.0000000000000001E-3,8.6299999999999999E-8]
["FEV1/FVC","rs13110699","4:89815695","FAM13A (intron)","T/G",0.82509999999999994,"rs2045517",-1.2E-2,8.0000000000000002E-3,0.157,8.9999999999999993E-3,8.0000000000000002E-3,0.307,-4.4999999999999998E-2,8.0000000000000002E-3,1.29E-7]
["FVC","rs91731","5:33334312","LOC340113/TARS","C/A",0.90539999999999998,"-",-5.8000000000000003E-2,1.0999999999999999E-2,3.4499999999999998E-7,-7.0000000000000007E-2,1.0999999999999999E-2,8.09E-10,-6.0000000000000001E-3,1.0999999999999999E-2,0.61399999999999999]
["FEV1/FVC","rs1551943","5:52195033","ITGA1 (intron)","G/A",0.23019999999999999,"-",-3.2000000000000001E-2,8.0000000000000002E-3,5.2500000000000002E-5,-1.2E-2,8.0000000000000002E-3,0.125,-5.1999999999999998E-2,8.0000000000000002E-3,3.12E-11]
["FVC","rs2441026","5:53444498","ARL15 (intron)","C/T",0.46260000000000001,"-",3.1E-2,7.0000000000000001E-3,3.76E-6,3.4000000000000002E-2,7.0000000000000001E-3,4.5999999999999999E-7,5.0000000000000001E-3,7.0000000000000001E-3,0.495]
["FEV1/FVC","rs7713065","5:131788334","C5orf56 (intron)","A/C",0.73670000000000002,"-",1.2E-2,8.0000000000000002E-3,9.7199999999999995E-2,-3.0000000000000001E-3,8.0000000000000002E-3,0.73499999999999999,3.9E-2,7.0000000000000001E-3,2.2100000000000001E-7]
["FEV1","rs3839234","5:148596693","ABLIM3 (intron)","G/-",0.47010000000000002,"-",-3.7999999999999999E-2,7.0000000000000001E-3,8.8699999999999994E-9,-3.3000000000000002E-2,7.0000000000000001E-3,1.08E-6,-2.8000000000000001E-2,7.0000000000000001E-3,3.15E-5]
["FEV1/FVC","rs10515750","5:156810072","CYFIP2 (intron)","C/T",7.1900000000000006E-2,"rs1990950",-4.3999999999999997E-2,1.2E-2,3.2499999999999999E-4,-0.02,1.2E-2,9.9599999999999994E-2,-6.3E-2,1.2E-2,2.6100000000000002E-7]
["FEV1/FVC","rs28986170","6:31556155","LST1 (intron)","-/AA",7.5300000000000006E-2,"rs2070600, rs201002132",5.6000000000000001E-2,1.2999999999999999E-2,3.0700000000000001E-5,3.1E-2,1.2999999999999999E-2,1.9E-2,7.6999999999999999E-2,1.2999999999999999E-2,1.2299999999999999E-8]
["FEV1","rs114229351","6:32648418","HLA-DQB1/HLA-DQA2 #","T/C",0.1754,"rs34864796",-4.5999999999999999E-2,8.9999999999999993E-3,1.15E-7,-3.1E-2,8.9999999999999993E-3,2.7700000000000001E-4,-0.05,8.9999999999999993E-3,6.7899999999999999E-9]
["FEV1/FVC","rs141651520","6:73670095","KCNQ5 (intron)","TTCTAT/-",0.2009,"-",1.4E-2,8.0000000000000002E-3,9.9099999999999994E-2,-4.0000000000000001E-3,8.0000000000000002E-3,0.64,4.2000000000000003E-2,8.0000000000000002E-3,3.3799999999999998E-7]
["FEV1/FVC","rs10246303","7:7286445","C1GALT1 (3’ UTR)","A/T",0.41749999999999998,"-",-2.8000000000000001E-2,7.0000000000000001E-3,4.4400000000000002E-5,-1.6E-2,7.0000000000000001E-3,1.55E-2,-3.4000000000000002E-2,7.0000000000000001E-3,4.4099999999999999E-7]
["FEV1/FVC","rs72615157","7:99635967","ZKSCAN1 (3’ UTR)","G/A",0.1673,"-",1.7000000000000001E-2,8.9999999999999993E-3,5.6800000000000003E-2,-2E-3,8.9999999999999993E-3,0.80900000000000005,4.5999999999999999E-2,8.9999999999999993E-3,2.6899999999999999E-7]
["FEV1","rs12698403","7:156127246","LOC389602/LOC285889","G/A",0.44340000000000002,"-",-3.5999999999999997E-2,7.0000000000000001E-3,7.4200000000000003E-8,-3.1E-2,7.0000000000000001E-3,4.0500000000000002E-6,-2.7E-2,7.0000000000000001E-3,6.3800000000000006E-5]
["FEV1","rs7872188","9:4124377","GLIS3 (intron)","C/T",0.40160000000000001,"-",-3.7999999999999999E-2,7.0000000000000001E-3,1.81E-8,-3.1E-2,7.0000000000000001E-3,5.1100000000000002E-6,-3.2000000000000001E-2,7.0000000000000001E-3,1.9099999999999999E-6]
["FVC","rs10870202","9:139257411","DNLZ (intron)","T/C",0.50009999999999999,"rs10858246",-2.7E-2,6.0000000000000001E-3,3.4600000000000001E-5,-3.3000000000000002E-2,6.0000000000000001E-3,3.2500000000000001E-7,-4.0000000000000001E-3,6.0000000000000001E-3,0.57499999999999996]
["FEV1/FVC","rs3847402","10:30267810","SVIL/KIAA1462","G/A",0.40589999999999998,"-",-2.8000000000000001E-2,7.0000000000000001E-3,4.6699999999999997E-5,-1.4E-2,7.0000000000000001E-3,4.3999999999999997E-2,-3.5999999999999997E-2,7.0000000000000001E-3,1.01E-7]
["FVC","rs7095607","10:69957350","MYPN (intron)","G/A",0.495,"-",-3.4000000000000002E-2,7.0000000000000001E-3,2.8000000000000002E-7,-3.6999999999999998E-2,7.0000000000000001E-3,3.92E-8,-1.2E-2,7.0000000000000001E-3,7.22E-2]
["FEV1","rs2509961","11:62310909","AHNAK (intron)","T/C",0.38219999999999998,"-",3.5999999999999997E-2,7.0000000000000001E-3,1.6899999999999999E-7,3.2000000000000001E-2,7.0000000000000001E-3,3.3799999999999998E-6,0.02,7.0000000000000001E-3,3.2100000000000002E-3]
["FEV1","rs11234757","11:86443072","ME3/PRSS23","G/A",0.15160000000000001,"-",-5.7000000000000002E-2,8.9999999999999993E-3,1.4200000000000001E-9,-4.4999999999999998E-2,8.9999999999999993E-3,1.95E-6,-4.8000000000000001E-2,8.9999999999999993E-3,2.7500000000000001E-7]
["FEV1","rs567508","11:126008910","CDON/RPUSD4","G/A",0.84930000000000005,"-",0.05,8.9999999999999993E-3,1.12E-7,3.9E-2,0.01,3.3699999999999999E-5,4.9000000000000002E-2,8.9999999999999993E-3,1.5599999999999999E-7]
["FEV1","rs1494502","12:65824670","MSRB3 (intron)","A/G",0.36209999999999998,"-",3.5999999999999997E-2,7.0000000000000001E-3,2.7300000000000002E-7,3.4000000000000002E-2,7.0000000000000001E-3,7.9400000000000004E-7,1.4E-2,7.0000000000000001E-3,3.7900000000000003E-2]
["FEV1/FVC","rs113745635","12:95554771","FGD6 (intron)","C/T",0.21179999999999999,"-",-2.9000000000000001E-2,8.0000000000000002E-3,3.5599999999999998E-4,-1.0999999999999999E-2,8.0000000000000002E-3,0.193,-0.05,8.0000000000000002E-3,3.4699999999999999E-10]
["FVC","rs35506","12:115500691","TBX3/MED13L","T/A",0.71240000000000003,"-",0.03,7.0000000000000001E-3,4.7599999999999998E-5,3.6999999999999998E-2,7.0000000000000001E-3,4.3000000000000001E-7,1E-3,7.0000000000000001E-3,0.871]
["FEV1/FVC","rs1698268","14:84309664","LINC01467/LINC00911","A/T",0.29459999999999997,"-",-1.6E-2,7.0000000000000001E-3,2.58E-2,-3.0000000000000001E-3,7.0000000000000001E-3,0.68400000000000005,-3.9E-2,7.0000000000000001E-3,1.12E-7]
["FEV1/FVC","rs72724130","15:41977690","MGA (intron)","A/T",5.7000000000000002E-2,"-",-3.1E-2,1.4E-2,2.9499999999999998E-2,-3.0000000000000001E-3,1.4999999999999999E-2,0.86199999999999999,-7.4999999999999997E-2,1.4E-2,2.05E-7]
["FEV1/FVC","rs12591467","15:71788387","THSD4 (intron)","C/T",0.68379999999999996,"rs10851839",0.02,7.0000000000000001E-3,3.9100000000000003E-3,6.0000000000000001E-3,7.0000000000000001E-3,0.41599999999999998,3.6999999999999998E-2,7.0000000000000001E-3,6.4500000000000002E-8]
["FEV1/FVC","rs66650179","15:84261689","SH3GL3 (intron)","A/-",0.81359999999999999,"-",-3.5000000000000003E-2,8.9999999999999993E-3,5.7599999999999997E-5,-0.02,8.9999999999999993E-3,2.4500000000000001E-2,-4.8000000000000001E-2,8.9999999999999993E-3,2.59E-8]
["FEV1/FVC","rs59835752","17:28265330","EFCAB5 (intron)","A/-",0.54359999999999997,"-",1.0999999999999999E-2,7.0000000000000001E-3,0.10100000000000001,-6.0000000000000001E-3,7.0000000000000001E-3,0.35399999999999998,4.1000000000000002E-2,7.0000000000000001E-3,4.1500000000000001E-10]
["FEV1/FVC","rs11658500","17:36886828","CISD3 (intron)","G/A",0.1416,"-",-4.1000000000000002E-2,8.9999999999999993E-3,1.3499999999999999E-5,-2.5000000000000001E-2,0.01,9.4000000000000004E-3,-5.0999999999999997E-2,8.9999999999999993E-3,4.6900000000000003E-8]
["FVC","rs6140050","20:6632901","CASC20/BMP2 ","C/A",0.63339999999999996,"-",2.7E-2,7.0000000000000001E-3,1.1400000000000001E-4,0.04,7.0000000000000001E-3,5.9699999999999999E-9,-8.9999999999999993E-3,7.0000000000000001E-3,0.18099999999999999]
["FEV1","rs72448466","20:62363640","ZGPAT (intron)","GT/-",0.67290000000000005,"-",-3.7999999999999999E-2,7.0000000000000001E-3,1.09E-7,-3.6999999999999998E-2,7.0000000000000001E-3,1.67E-7,-1.4E-2,7.0000000000000001E-3,4.07E-2]
["FEV1","rs11704827","22:18450287","MICAL3 (intron)","A/T",0.23139999999999999,"-",4.9000000000000002E-2,8.0000000000000002E-3,6.0899999999999996E-10,4.7E-2,8.0000000000000002E-3,3.7E-9,2.5000000000000001E-2,8.0000000000000002E-3,1.6999999999999999E-3]
["FEV1","rs2283847","22:28181399","MN1 (intron)","C/T",0.55500000000000005,"-",-3.7999999999999999E-2,7.0000000000000001E-3,2.4E-8,-3.4000000000000002E-2,7.0000000000000001E-3,1.22E-6,-2.9000000000000001E-2,7.0000000000000001E-3,2.5899999999999999E-5]
["# rs114229351 was a novel secondary signal that was identified in an analysis conditioned on rs34864796 (near ZKSCAN3) which was previously reported for FEV1 and which was most strongly associated with FEV1 in our analysis. rs114229351 was subsequently found to be more strongly associated with FEV1/FVC in our analysis. "]
[]
["b) 54 previously reported signals"]
["Trait","rsid","Position (b37)","Gene*","Non/coded allele","Effect allele frequency","Previous study",null,"FEV1",null,null,"FVC",null,null,"FEV1/FVC"]
[{"$nulls":7},"beta","se","p","beta","se","p","beta","se","p"]
["FEV1/FVC","rs2284746","1:17306675","MFAP2","C/G",0.52180000000000004,"Soler Artigas  et al (2011)",-4.0000000000000001E-3,7.0000000000000001E-3,0.59099999999999997,1.4999999999999999E-2,7.0000000000000001E-3,2.8899999999999999E-2,-4.2000000000000003E-2,7.0000000000000001E-3,1.43E-10]
["FEV1","rs6681426","1:150586971","ENSA","G/A",0.65190000000000003,"Soler Artigas  et al (2015)",-0.02,7.0000000000000001E-3,3.5500000000000002E-3,-2.5000000000000001E-2,7.0000000000000001E-3,3.6900000000000002E-4,2E-3,7.0000000000000001E-3,0.73899999999999999]
["FEV1/FVC","rs993925","1:218860068","TGFB2","C/T",0.34810000000000002,"Soler Artigas  et al (2011)",1.9E-2,7.0000000000000001E-3,6.6899999999999998E-3,1.4999999999999999E-2,7.0000000000000001E-3,2.93E-2,2.3E-2,7.0000000000000001E-3,9.01E-4]
["FEV1/FVC","rs4328080","1:219963088","RNU5F-1","G/A",0.622,"Soler Artigas  et al (2015)",1.7000000000000001E-2,7.0000000000000001E-3,1.61E-2,8.9999999999999993E-3,7.0000000000000001E-3,0.20899999999999999,2.5999999999999999E-2,7.0000000000000001E-3,1.2300000000000001E-4]
["FEV1/FVC","rs62126408","2:18309132","KCNS3","T/C",0.1411,"Soler Artigas  et al (2015)",5.1999999999999998E-2,0.01,6.7099999999999999E-8,3.9E-2,0.01,4.1600000000000002E-5,5.5E-2,0.01,8.2299999999999999E-9]
["FVC","rs1430193","2:56120853","EFEMP1","A/T",0.34939999999999999,"Loth et al (2014)",-1.6E-2,7.0000000000000001E-3,2.4500000000000001E-2,-1.9E-2,7.0000000000000001E-3,7.2100000000000003E-3,-1E-3,7.0000000000000001E-3,0.92900000000000005]
["FEV1","rs2571445","2:218683154","TNS1","A/G",0.60009999999999997,"Repapi et al (2010)",4.2999999999999997E-2,7.0000000000000001E-3,2.1899999999999999E-10,3.3000000000000002E-2,7.0000000000000001E-3,1.2699999999999999E-6,3.6999999999999998E-2,7.0000000000000001E-3,4.9199999999999997E-8]
["FEV1/FVC","rs10498230","2:229502503","PID1","C/T",7.9299999999999995E-2,"Hancock et al (2010)",3.5999999999999997E-2,1.2E-2,3.31E-3,3.0000000000000001E-3,1.2E-2,0.83199999999999996,8.3000000000000004E-2,1.2E-2,8.9099999999999998E-12]
["FEV1/FVC","rs12477314","2:239877148","HDAC4","C/T",0.19670000000000001,"Soler Artigas  et al (2011)",2.5000000000000001E-2,8.0000000000000002E-3,2.7399999999999998E-3,1.6E-2,8.0000000000000002E-3,6.0499999999999998E-2,3.3000000000000002E-2,8.0000000000000002E-3,6.9999999999999994E-5]
["FEV1/FVC","rs1529672","3:25520582","RARB","C/A",0.17460000000000001,"Soler Artigas  et al (2011)",1.6E-2,8.9999999999999993E-3,6.8099999999999994E-2,2E-3,8.9999999999999993E-3,0.81499999999999995,3.5000000000000003E-2,8.9999999999999993E-3,7.2999999999999999E-5]
["FVC","rs1595029","3:158241767","RP11-538P18.2/AK097794","A/C",0.4798,"Soler Artigas  et al (2015)",-3.4000000000000002E-2,7.0000000000000001E-3,3.6899999999999998E-7,-3.7999999999999999E-2,7.0000000000000001E-3,9.8299999999999993E-9,-4.0000000000000001E-3,7.0000000000000001E-3,0.51500000000000001]
["FEV1","rs1344555","3:169300219","MECOM","C/T",0.20319999999999999,"Soler Artigas  et al (2011)",-2.5000000000000001E-2,8.0000000000000002E-3,2.2599999999999999E-3,-1.9E-2,8.0000000000000002E-3,2.06E-2,-2.7E-2,8.0000000000000002E-3,1.2099999999999999E-3]
["FEV1/FVC","rs2045517","4:89870964","FAM13A","C/T",0.40689999999999998,"Hancock et al (2010)",-8.9999999999999993E-3,7.0000000000000001E-3,0.185,1.0999999999999999E-2,7.0000000000000001E-3,0.111,-4.5999999999999999E-2,7.0000000000000001E-3,1.2200000000000001E-11]
["FEV1","rs34480284","4:106064626","TET2","-/A",0.37369999999999998,"Wain et al (2015)",3.9E-2,7.0000000000000001E-3,8.9000000000000003E-9,2.8000000000000001E-2,7.0000000000000001E-3,5.0899999999999997E-5,3.9E-2,7.0000000000000001E-3,1.3399999999999999E-8]
["FEV1","rs10516526","4:106688904","GSTCD","A/G",6.2799999999999995E-2,"Repapi et al (2010)/ Hancock et al (2010)",7.4999999999999997E-2,1.4E-2,3.9599999999999997E-8,6.0999999999999999E-2,1.4E-2,8.14E-6,5.6000000000000001E-2,1.4E-2,3.82E-5]
["FEV1/FVC","rs34712979","4:106819053","NPNT","G/A",0.26200000000000001,"Wain et al (2015)",-7.1999999999999995E-2,8.0000000000000002E-3,1.8800000000000001E-21,-4.3999999999999997E-2,8.0000000000000002E-3,7.5499999999999998E-9,-8.6999999999999994E-2,7.0000000000000001E-3,2.3900000000000002E-31]
["FEV1/FVC","rs138641402","4:145445779","HHIP","A/T",0.38080000000000003,"Wilk et al (2009)",4.5999999999999999E-2,7.0000000000000001E-3,1.9500000000000001E-11,1.6E-2,7.0000000000000001E-3,2.0799999999999999E-2,8.2000000000000003E-2,7.0000000000000001E-3,5.2899999999999997E-33]
["FEV1/FVC","rs153916","5:95036700","SPATA9","C/T",0.54930000000000001,"Soler Artigas et al (2011)",-4.0000000000000001E-3,7.0000000000000001E-3,0.54400000000000004,7.0000000000000001E-3,7.0000000000000001E-3,0.29099999999999998,-2.5999999999999999E-2,7.0000000000000001E-3,1.16E-4]
["FEV1","rs7715901","5:147856392","HTR4","A/G",0.3957,"Repapi et al (2010)/ Hancock et al (2010)",4.5999999999999999E-2,7.0000000000000001E-3,1.5E-11,2.1999999999999999E-2,7.0000000000000001E-3,1.34E-3,6.6000000000000003E-2,7.0000000000000001E-3,8.3699999999999996E-23]
["FEV1/FVC","rs1990950","5:156920756","ADAM19","G/T",0.3906,"Hancock et al (2010)",2.9000000000000001E-2,7.0000000000000001E-3,1.6200000000000001E-5,1.4999999999999999E-2,7.0000000000000001E-3,2.3199999999999998E-2,4.4999999999999998E-2,7.0000000000000001E-3,2.6899999999999999E-11]
["FVC","rs6924424","6:7801611","BMP6","T/G",0.1547,"Loth et al (2014)",-3.4000000000000002E-2,8.9999999999999993E-3,2.1900000000000001E-4,-4.1000000000000002E-2,8.9999999999999993E-3,1.0499999999999999E-5,3.0000000000000001E-3,8.9999999999999993E-3,0.73699999999999999]
["FEV1","rs34864796","6:27459923","ZKSCAN3","G/A",0.12740000000000001,"Soler Artigas et al (2011)",-7.4999999999999997E-2,0.01,6.1399999999999996E-14,-6.2E-2,0.01,4.5299999999999999E-10,-6.2E-2,0.01,3.5200000000000003E-10]
["FEV1/FVC","rs2857595","6:31568469","NCR3","G/A",0.21299999999999999,"Soler Artigas et al (2011)",-3.9E-2,8.0000000000000002E-3,2.0499999999999999E-6,-2.5999999999999999E-2,8.0000000000000002E-3,1.2899999999999999E-3,-4.8000000000000001E-2,8.0000000000000002E-3,3.4999999999999999E-9]
["FEV1/FVC","rs2070600","6:32151443","AGER","C/T",6.3399999999999998E-2,"Repapi et al (2010)/ Hancock et al (2010)",3.9E-2,1.4E-2,4.15E-3,-1.7000000000000001E-2,1.4E-2,0.20300000000000001,0.14000000000000001,1.4E-2,3.1099999999999999E-25]
["FEV1","rs114544105","6:32635629","HLA-DQB1","G/A",0.26979999999999998,"Wain et al (2015)",-4.9000000000000002E-2,8.0000000000000002E-3,8.84E-11,-0.03,8.0000000000000002E-3,8.9400000000000005E-5,-6.3E-2,8.0000000000000002E-3,5.2000000000000001E-17]
["FEV1/FVC","rs2768551","6:109270656","ARMC2","G/A",0.191,"Soler Artigas et al (2011)",-2.5000000000000001E-2,8.0000000000000002E-3,2.5699999999999998E-3,-7.0000000000000001E-3,8.0000000000000002E-3,0.433,-5.5E-2,8.0000000000000002E-3,6.2299999999999994E-11]
["FEV1/FVC","rs7753012","6:142745883","LOC153910/GPR126","T/G",0.30180000000000001,"Hancock et al (2010)",4.5999999999999999E-2,7.0000000000000001E-3,2.1E-10,1.4E-2,7.0000000000000001E-3,5.1400000000000001E-2,8.4000000000000005E-2,7.0000000000000001E-3,2.29E-31]
["FEV1/FVC","rs148274477","6:142838173","GPR126","C/T",2.63E-2,"Soler Artigas et al (2015)",6.3E-2,2.1000000000000001E-2,2.5100000000000001E-3,-1.6E-2,2.1000000000000001E-2,0.45600000000000002,0.17499999999999999,2.1000000000000001E-2,4.4800000000000002E-17]
["FEV1/FVC","rs16909859","9:98204792","PTCH1","G/A",8.0500000000000002E-2,"Hancock et al (2010)",2E-3,1.2E-2,0.877,2.7E-2,1.2E-2,2.7400000000000001E-2,-0.05,1.2E-2,3.9499999999999998E-5]
["FEV1/FVC","rs803923","9:119401650","ASTN2","G/A",0.53949999999999998,"Soler Artigas et al (2015)",-1.2999999999999999E-2,7.0000000000000001E-3,4.6899999999999997E-2,-2E-3,7.0000000000000001E-3,0.71299999999999997,-3.3000000000000002E-2,7.0000000000000001E-3,4.34E-7]
["FVC","rs10858246","9:139102831","LHX3","G/C",0.32019999999999998,"Soler Artigas et al (2015)",-0.03,7.0000000000000001E-3,2.4899999999999999E-5,-3.9E-2,7.0000000000000001E-3,3.5600000000000001E-8,0,7.0000000000000001E-3,0.98299999999999998]
["FEV1/FVC","rs7090277","10:12278021","CDC123","T/A",0.51580000000000004,"Soler Artigas et al (2011)",4.4999999999999998E-2,7.0000000000000001E-3,1.23E-11,0.03,7.0000000000000001E-3,5.04E-6,5.3999999999999999E-2,7.0000000000000001E-3,2.1600000000000001E-16]
["FEV1","rs2637254","10:78312002","C10orf11","G/A",0.51259999999999994,"Soler Artigas et al (2011)",-3.5999999999999997E-2,7.0000000000000001E-3,4.7799999999999998E-8,-3.4000000000000002E-2,7.0000000000000001E-3,3.5400000000000002E-7,-2.5000000000000001E-2,7.0000000000000001E-3,1.1900000000000001E-4]
["FVC","rs4237643","11:43648368","HSD17B12","T/G",0.68610000000000004,"Loth et al (2014)",1.7999999999999999E-2,7.0000000000000001E-3,1.35E-2,1.7999999999999999E-2,7.0000000000000001E-3,1.03E-2,4.0000000000000001E-3,7.0000000000000001E-3,0.53100000000000003]
["FVC","rs2863171","11:45250732","PRDM11","A/C",0.15609999999999999,"Loth et al (2014)",1.7000000000000001E-2,8.9999999999999993E-3,5.7700000000000001E-2,1.7999999999999999E-2,8.9999999999999993E-3,4.3999999999999997E-2,6.0000000000000001E-3,8.9999999999999993E-3,0.50700000000000001]
["FVC","rs2348418","12:28689514","CCDC91","T/C",0.4536,"Soler Artigas et al (2015)",-3.5000000000000003E-2,7.0000000000000001E-3,1.04E-7,-4.2000000000000003E-2,7.0000000000000001E-3,3.3800000000000002E-10,-3.0000000000000001E-3,7.0000000000000001E-3,0.65100000000000002]
["FEV1/FVC","rs11172113","12:57527283","LRP1","T/C",0.41360000000000002,"Soler Artigas et al (2011)",1.2999999999999999E-2,7.0000000000000001E-3,6.0100000000000001E-2,8.0000000000000002E-3,7.0000000000000001E-3,0.249,1.9E-2,7.0000000000000001E-3,4.8500000000000001E-3]
["FEV1/FVC","rs12820313","12:96255704","CCDC38","T/C",0.79310000000000003,"Soler Artigas et al (2011)",-1.4E-2,8.0000000000000002E-3,8.6400000000000005E-2,2E-3,8.0000000000000002E-3,0.80600000000000005,-4.3999999999999997E-2,8.0000000000000002E-3,5.39E-8]
["FEV1","12:114743533","12:114743533","RBM19","T/C",0.99850000000000005,"Wain et al (2015)",-0.217,9.6000000000000002E-2,2.4400000000000002E-2,-0.25600000000000001,9.8000000000000004E-2,8.9999999999999993E-3,-7.1999999999999995E-2,9.7000000000000003E-2,0.45900000000000002]
["FEV1","rs10850377","12:115201436","TBX3","G/A",0.34260000000000002,"Soler Artigas et al (2015)",2.5000000000000001E-2,7.0000000000000001E-3,3.9399999999999998E-4,2.5000000000000001E-2,7.0000000000000001E-3,3.19E-4,6.0000000000000001E-3,7.0000000000000001E-3,0.40600000000000003]
["FEV1","rs7155279","14:92485881","TRIP11","G/T",0.3634,"Soler Artigas et al (2015)",2.1000000000000001E-2,7.0000000000000001E-3,2.0999999999999999E-3,1.7999999999999999E-2,7.0000000000000001E-3,1.0800000000000001E-2,1.4E-2,7.0000000000000001E-3,3.7999999999999999E-2]
["FEV1","rs117068593","14:93118229","RIN3","C/T",0.1913,"Soler Artigas et al (2015)",2.8000000000000001E-2,8.0000000000000002E-3,1.07E-3,2.1999999999999999E-2,8.9999999999999993E-3,1.0200000000000001E-2,0.02,8.0000000000000002E-3,2.0199999999999999E-2]
["FEV1/FVC","rs10851839","15:71628370","THSD4","T/A",0.66869999999999996,"Repapi et al (2010)",2.7E-2,7.0000000000000001E-3,1.4100000000000001E-4,-4.0000000000000001E-3,7.0000000000000001E-3,0.58799999999999997,7.1999999999999995E-2,7.0000000000000001E-3,1.4499999999999999E-24]
["FEV1/FVC","rs12149828","16:10706328","TEKT5","G/A",0.16189999999999999,"Soler Artigas et al (2015)",-2.7E-2,8.9999999999999993E-3,3.3600000000000001E-3,-1.4E-2,8.9999999999999993E-3,0.14399999999999999,-3.5999999999999997E-2,8.9999999999999993E-3,8.8999999999999995E-5]
["FEV1/FVC","rs12447804","16:58075282","MMP15","C/T",0.2213,"Soler Artigas et al (2011)",-1.0999999999999999E-2,8.0000000000000002E-3,0.159,4.0000000000000001E-3,8.0000000000000002E-3,0.64,-3.4000000000000002E-2,8.0000000000000002E-3,2.41E-5]
["FEV1/FVC","rs3743609","16:75467021","CFDP1","G/C",0.5907,"Soler Artigas et al (2011)",-3.1E-2,7.0000000000000001E-3,4.1300000000000003E-6,-1.9E-2,7.0000000000000001E-3,6.3E-3,-4.2000000000000003E-2,7.0000000000000001E-3,3.6199999999999999E-10]
["FVC","rs1079572","16:78187138","WWOX","G/A",0.58099999999999996,"Loth et al (2014)",-0.02,7.0000000000000001E-3,3.5200000000000001E-3,-2.4E-2,7.0000000000000001E-3,3.4200000000000002E-4,4.0000000000000001E-3,7.0000000000000001E-3,0.52700000000000002]
["FEV1","rs35524223","17:44192590","KANSL1","T/A",0.21659999999999999,"Wain et al (2015)",-6.0999999999999999E-2,8.0000000000000002E-3,1.13E-13,-5.8999999999999997E-2,8.0000000000000002E-3,7.3999999999999998E-13,-3.3000000000000002E-2,8.0000000000000002E-3,4.1999999999999998E-5]
["FVC","rs6501431","17:68976415","KCNJ2","C/T",0.78420000000000001,"Loth et al (2014)",0,8.0000000000000002E-3,0.96399999999999997,5.0000000000000001E-3,8.0000000000000002E-3,0.56100000000000005,-1E-3,8.0000000000000002E-3,0.91300000000000003]
["FEV1","rs7218675","17:73513185","TSEN54","C/A",0.71109999999999995,"Wain et al (2015)",-3.5000000000000003E-2,7.0000000000000001E-3,2.34E-6,-3.1E-2,7.0000000000000001E-3,3.1699999999999998E-5,-2.1000000000000001E-2,7.0000000000000001E-3,4.7999999999999996E-3]
["FEV1/FVC","rs113473882","19:41124155","LTBP4","T/C",9.5999999999999992E-3,"Soler Artigas et al (2015)",4.0000000000000001E-3,3.5000000000000003E-2,0.90400000000000003,-6.0999999999999999E-2,3.5000000000000003E-2,8.0299999999999996E-2,0.14499999999999999,3.5000000000000003E-2,3.0300000000000001E-5]
["FEV1/FVC","rs2834440","21:35690499","KCNE2","G/A",0.6159,"Soler Artigas et al (2011)",1.4E-2,7.0000000000000001E-3,4.2500000000000003E-2,-1E-3,7.0000000000000001E-3,0.89100000000000001,3.5999999999999997E-2,7.0000000000000001E-3,1.6E-7]
["FEV1","rs134041","22:28056338","MN1","T/C",0.56120000000000003,"Soler Artigas et al (2015)",1.9E-2,7.0000000000000001E-3,4.4900000000000001E-3,1.6E-2,7.0000000000000001E-3,2.0899999999999998E-2,1.9E-2,7.0000000000000001E-3,3.8500000000000001E-3]
["FEV1/FVC","rs7050036","X:15964845","AP1S2","T/A",0.60880000000000001,"Soler Artigas et al (2015)",2E-3,5.0000000000000001E-3,0.753,-6.0000000000000001E-3,5.0000000000000001E-3,0.30099999999999999,1.0999999999999999E-2,5.0000000000000001E-3,3.5499999999999997E-2]

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["a)      European ancestry – variants for which UK BiLEVE data was not included in original discovery"]
[{"$nulls":4},"eMR",null,null,null,"COPD case control",null,null,null,"lung resection",null,null,null,"deCODE COPD",null,null,null,"UK Biobank (including UK BiLEVE)",null,null,null,"All",{"$nulls":4},"Sample sizes"]
["Sentinel rsid","Proxy rsid","chr:position b37","Non/coded alleles","OR","lower 95% CI","upper 95% CI","P","OR","lower 95% CI","upper 95% CI","P","OR","lower 95% CI","upper 95% CI","P","OR","lower 95% CI","upper 95% CI","P","OR","lower 95% CI","upper 95% CI","P","Effect allele freq","OR","lower 95% CI","upper 95% CI","P","Cases","Controls"]
["rs2284746","rs2284746","1:17306675","C/G",1.03,0.95,1.1100000000000001,0.53,1.06,0.99,1.1299999999999999,8.9800000000000005E-2,0.94,0.74,1.19,0.629,0.99,0.92,1.07,0.85799999999999998,1.06,1.03,1.0900000000000001,1.95E-4,0.52500000000000002,1.05,1.02,1.07,2.0699999999999999E-4,19950.2,214939.4]
["rs6681426","rs6681426","1:150586971","G/A",0.99,0.91,1.07,0.82299999999999995,1.01,0.94,1.08,0.82799999999999996,1.2,0.93,1.54,0.16300000000000001,1.02,0.95,1.1000000000000001,0.54900000000000004,1.02,0.98,1.05,0.35799999999999998,0.63700000000000001,1.01,0.99,1.04,0.27600000000000002,20008,215118.9]
["rs993925","rs993925","1:218860068","T/C",0.98,0.9,1.06,0.56499999999999995,1.06,0.99,1.1299999999999999,0.11700000000000001,0.9,0.7,1.1599999999999999,0.42799999999999999,1.01,0.94,1.0900000000000001,0.75800000000000001,0.98,0.95,1.02,0.32100000000000001,0.64500000000000002,1.02,0.99,1.04,0.223,19952.599999999999,214673]
["rs4328080","rs4328080","1:219963088","A/G",1,0.92,1.08,0.98299999999999998,1.02,0.96,1.1000000000000001,0.497,0.88,0.69,1.1200000000000001,0.30599999999999999,1.04,0.97,1.1200000000000001,0.254,0.95,0.92,0.98,9.1399999999999999E-4,0.38900000000000001,1.04,1.02,1.07,1.64E-3,19795.2,214169.60000000001]
["rs62126408","rs62126408","2:18309132","C/T",0.98,0.88,1.1000000000000001,0.76600000000000001,1.04,0.95,1.1399999999999999,0.39300000000000002,0.86,0.62,1.2,0.38500000000000001,1.02,0.93,1.1299999999999999,0.65400000000000003,0.9,0.86,0.94,1.9300000000000002E-6,0.83899999999999997,1.07,1.04,1.1100000000000001,5.9500000000000003E-5,19786.900000000001,214358.1]
["rs1430193","rs1430193","2:56120853","A/T",0.94,0.87,1.02,0.16700000000000001,0.96,0.89,1.02,0.191,1.23,0.96,1.57,0.104,0.98,0.91,1.06,0.65300000000000002,1,0.97,1.03,0.99399999999999999,0.33800000000000002,0.99,0.96,1.01,0.35399999999999998,19579,213705.7]
["rs2571445","rs2571445","2:218683154","G/A",1.06,0.98,1.1499999999999999,0.13200000000000001,1.06,0.99,1.1399999999999999,8.0299999999999996E-2,1.19,0.94,1.51,0.156,1.01,0.94,1.08,0.89100000000000001,0.92,0.89,0.95,9.6499999999999997E-8,0.379,1.07,1.05,1.1000000000000001,2.9099999999999999E-8,20051.5,215102.5]
["rs10498230","rs10498230","2:229502503","T/C",1.02,0.87,1.2,0.77300000000000002,1.32,1.1599999999999999,1.51,2.1100000000000001E-5,1.1299999999999999,0.7,1.82,0.60899999999999999,1.1000000000000001,0.97,1.24,0.13700000000000001,0.9,0.85,0.96,4.5800000000000002E-4,0.91200000000000003,1.1200000000000001,1.07,1.18,5.6000000000000004E-7,20048.900000000001,214918.3]
["rs12477314","rs12477314","2:239877148","T/C",1.06,0.96,1.17,0.23899999999999999,1.07,0.99,1.1599999999999999,0.109,1.38,1.03,1.84,3.09E-2,1.1399999999999999,1.04,1.24,6.8399999999999997E-3,0.92,0.89,0.96,3.3500000000000001E-5,0.79700000000000004,1.0900000000000001,1.06,1.1200000000000001,6.1999999999999999E-8,20068.3,215341.8]
["rs1529672","rs1529672","3:25520582","A/C",1.07,0.96,1.19,0.20100000000000001,1.1399999999999999,1.05,1.25,2.98E-3,1.22,0.89,1.68,0.21199999999999999,1.04,0.95,1.1399999999999999,0.40400000000000003,0.95,0.91,0.99,1.7399999999999999E-2,0.81799999999999995,1.07,1.03,1.1000000000000001,1.3999999999999999E-4,19884.3,214056.5]
["rs1595029","rs1595029","3:158241767","A/C",1.04,0.96,1.1200000000000001,0.34100000000000003,1.05,0.99,1.1200000000000001,0.126,1.07,0.84,1.35,0.58599999999999997,"-","-","-","-",1.03,1,1.07,4.6199999999999998E-2,0.47899999999999998,1.04,1.01,1.06,7.3400000000000002E-3,18092.900000000001,73022.899999999994]
["rs1344555","rs1344555","3:169300219","C/T",0.94,0.85,1.03,0.189,1.01,0.92,1.1000000000000001,0.874,1.1499999999999999,0.84,1.57,0.39800000000000002,1,0.92,1.08,0.98,1.03,0.99,1.07,0.20200000000000001,0.192,1.01,0.98,1.04,0.46300000000000002,19846.3,215051.3]
["rs2045517","rs2045517","4:89870964","C/T",1.01,0.94,1.1000000000000001,0.73499999999999999,1.28,1.2,1.37,5.5499999999999996E-13,1.19,0.94,1.51,0.158,1.0900000000000001,1.02,1.18,1.3100000000000001E-2,1.08,1.05,1.1200000000000001,1.11E-6,0.42899999999999999,1.1000000000000001,1.08,1.1299999999999999,1.8300000000000002E-14,20063.900000000001,215305]
["rs10516526","rs10516526","4:106688904","G/A",1.18,1,1.39,4.5100000000000001E-2,1.23,1.08,1.41,2.1700000000000001E-3,0.99,0.62,1.57,0.97,1.01,0.86,1.18,0.91,0.9,0.84,0.96,7.2300000000000001E-4,0.94199999999999995,1.1200000000000001,1.07,1.18,5.9399999999999999E-6,20070,215342.9]
["rs138641402","rs138641402","4:145445779","T/A",1.08,1,1.18,6.4100000000000004E-2,1.31,1.22,1.41,8.1900000000000004E-13,1.34,1.03,1.74,2.8199999999999999E-2,1.0900000000000001,1.01,1.17,2.2200000000000001E-2,0.85,0.82,0.88,1.69E-23,0.58399999999999996,1.17,1.1399999999999999,1.2,6.0499999999999999E-34,19076,213755.5]
["rs153916","rs153916","5:95036700","C/T",1.04,0.96,1.1200000000000001,0.373,1.03,0.97,1.1000000000000001,0.34899999999999998,1.04,0.82,1.32,0.746,1.06,0.99,1.1399999999999999,0.121,1.04,1.01,1.07,1.1299999999999999E-2,0.53800000000000003,1.04,1.02,1.07,1.32E-3,20028,215152.3]
["rs7715901","rs7715901","5:147856392","G/A",1.03,0.95,1.1200000000000001,0.46800000000000003,1.1200000000000001,1.05,1.2,1.34E-3,1.21,0.94,1.54,0.13200000000000001,1,0.93,1.07,0.91300000000000003,0.88,0.85,0.91,1.3100000000000001E-14,0.60899999999999999,1.1000000000000001,1.08,1.1299999999999999,2.2400000000000001E-14,19332.099999999999,214653.1]
["rs1990950","rs1990950","5:156920756","T/G",1.01,0.94,1.1000000000000001,0.74299999999999999,1.1000000000000001,1.03,1.18,4.2900000000000004E-3,1.1499999999999999,0.91,1.44,0.247,1.03,0.96,1.1100000000000001,0.41799999999999998,0.93,0.9,0.96,3.18E-6,0.6,1.07,1.04,1.1000000000000001,1.31E-7,20069.900000000001,215336.6]
["rs6924424","rs6924424","6:7801611","T/G",1.05,0.94,1.18,0.34799999999999998,1,0.92,1.1000000000000001,0.93,1.36,0.98,1.88,6.4100000000000004E-2,0.91,0.83,1.01,7.17E-2,1.01,0.96,1.05,0.78400000000000003,0.16,1,0.97,1.04,0.91400000000000003,19221.2,210894.4]
["rs34864796","rs34864796","6:27459923","G/A",0.9,0.78,1.04,0.14599999999999999,1.07,0.96,1.2,0.23200000000000001,0.87,0.59,1.27,0.46700000000000003,1.07,0.94,1.23,0.318,1.1599999999999999,1.1100000000000001,1.22,3.5600000000000001E-10,8.7999999999999995E-2,1.1200000000000001,1.07,1.1599999999999999,3.99E-8,20045.2,215299.20000000001]
["rs2857595","rs2857595 ","6:31568469","G/A",1,0.9,1.1100000000000001,0.97299999999999998,0.97,0.9,1.06,0.54,1.24,0.92,1.67,0.159,1.06,0.97,1.1499999999999999,0.23,1.1100000000000001,1.07,1.1599999999999999,2.88E-8,0.20599999999999999,1.08,1.05,1.1100000000000001,1.6300000000000001E-6,19998.2,214226.5]
["rs2070600","rs2070600","6:32151443","T/C",1.0900000000000001,0.88,1.33,0.43099999999999999,1.42,1.21,1.67,1.31E-5,1.07,0.64,1.78,0.81,1.0900000000000001,0.91,1.31,0.33400000000000002,0.83,0.78,0.89,1.4E-8,0.95099999999999996,1.2,1.1399999999999999,1.27,1.0199999999999999E-11,20066.7,215117]
["rs2768551","rs2768551","6:109270656","G/A",1.01,0.92,1.1200000000000001,0.79300000000000004,1.1399999999999999,1.05,1.24,1.5200000000000001E-3,1.29,0.96,1.73,9.5699999999999993E-2,1.08,0.99,1.19,8.6300000000000002E-2,1.07,1.03,1.1100000000000001,9.0899999999999998E-4,0.187,1.08,1.04,1.1100000000000001,2.9000000000000002E-6,20030.3,215214.2]
["rs7753012","rs7753012","6:142745883","G/T",1.06,0.98,1.1599999999999999,0.154,1.05,0.98,1.1299999999999999,0.14499999999999999,1.19,0.92,1.55,0.182,1.07,0.98,1.1599999999999999,0.123,0.86,0.83,0.89,3.1999999999999998E-19,0.71899999999999997,1.1299999999999999,1.1000000000000001,1.1599999999999999,1.2799999999999999E-18,19946.2,214674.5]
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[]
[]
["b)      European ancestry – variants for which UK BiLEVE data was included in original discovery"]
[{"$nulls":4},"eMR",null,null,null,"COPD case control",null,null,null,"lung resection",null,null,null,"deCODE COPD",null,null,null,"UK Biobank (excluding UK BiLEVE)",null,null,null,"All (excluding UK BiLEVE samples)",{"$nulls":4},"Sample sizes"]
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["rs66650179","rs66650179","15:84261689","A/-","-","-","-","-","-","-","-","-","-","-","-","-",1.04,0.95,1.1399999999999999,0.41499999999999998,1.05,0.93,1.18,0.47199999999999998,0.82,1.04,0.97,1.1200000000000001,0.27800000000000002,2892.1,167128.20000000001]
["rs59835752","rs59835752 ","17:28265330","-/A","-","-","-","-","-","-","-","-","-","-","-","-",0.96,0.9,1.04,0.33600000000000002,1.1399999999999999,1.04,1.25,6.9300000000000004E-3,0.41599999999999998,1.03,0.97,1.0900000000000001,0.377,2943.8,168634]
["rs11658500","rs11658500","17:36886828","G/A",0.94,0.84,1.06,0.31,1.07,0.97,1.19,0.14899999999999999,1.05,0.75,1.46,0.78500000000000003,1.1000000000000001,0.99,1.21,7.0999999999999994E-2,1.02,0.89,1.17,0.8,0.13900000000000001,1.04,0.99,1.1000000000000001,0.153,10147.200000000001,187633.8]
["rs35524223","rs35524223","17:44192590","T/A",1.17,0.91,1.5,0.22700000000000001,"-","-","-","-",1.22,0.89,1.66,0.217,0.99,0.91,1.0900000000000001,0.86199999999999999,0.97,0.87,1.0900000000000001,0.63900000000000001,0.188,1.01,0.94,1.08,0.84699999999999998,3373.4,170025.3]
["rs7218675","rs7218675","17:73513185","C/A",1.05,0.97,1.1499999999999999,0.222,0.99,0.92,1.06,0.79800000000000004,1.04,0.79,1.36,0.78300000000000003,0.97,0.89,1.05,0.40100000000000002,0.99,0.89,1.1000000000000001,0.877,0.69799999999999995,1,0.96,1.04,0.98399999999999999,10267.6,184975.7]
["rs6140050","rs6140050","20:6632901","A/C",1,0.92,1.08,0.91300000000000003,1.02,0.95,1.0900000000000001,0.66200000000000003,1.1000000000000001,0.85,1.41,0.46600000000000003,0.98,0.91,1.06,0.64300000000000002,0.93,0.85,1.03,0.154,0.35199999999999998,1.01,0.97,1.05,0.51900000000000002,10359.200000000001,187665.8]
["rs72448466","rs72448466","20:62363640","GT/-",1.06,0.97,1.1599999999999999,0.16700000000000001,1.04,0.97,1.1200000000000001,0.316,1.01,0.78,1.31,0.94,1.01,0.93,1.0900000000000001,0.86199999999999999,1.07,0.97,1.18,0.19,0.61199999999999999,1.04,1,1.08,6.3500000000000001E-2,10051.200000000001,182772.8]
["rs11704827","rs11704827","22:18450287","T/A",1.02,0.93,1.1200000000000001,0.69199999999999995,1.02,0.94,1.1000000000000001,0.65100000000000002,1.01,0.76,1.33,0.96799999999999997,1.02,0.93,1.1100000000000001,0.74399999999999999,0.89,0.8,1,5.1400000000000001E-2,0.80300000000000005,1.03,0.99,1.08,0.159,10403.299999999999,187284.4]
["rs2283847","rs2283847","22:28181399","C/T",1.1000000000000001,1.02,1.19,1.34E-2,1.03,0.97,1.1000000000000001,0.32500000000000001,0.86,0.68,1.0900000000000001,0.222,1.07,1,1.1599999999999999,6.1800000000000001E-2,1.03,0.93,1.1299999999999999,0.621,0.59199999999999997,1.05,1.01,1.0900000000000001,6.5799999999999999E-3,10425.5,185512.6]
[]
[]
["c)      Chinese ancestry (CKB)"]
["Sentinel rsid","Proxy rsid","Proxy chr:position b37","Non/coded allele","Effect allele freq","OR","lower 95% CI","upper 95% CI","Direction of effect consistent with COPD in European Ancestry?*","P","N cases","N controls"]
["rs2284746","rs2284746","1:17306675","C/G",0.28189999999999998,1.01,0.98,1.05,"Yes",0.54500000000000004,10545,77372]
["rs17513135","rs4660293","1:40028180","A/G",0.12039999999999999,0.96,0.9,1.03,"No",0.26700000000000002,7094,20872]
["rs1192404","rs1192415","1:92077097","A/G",0.14099999999999999,1.02,0.96,1.0900000000000001,"Yes",0.53500000000000003,7109,20903]
["rs200154334","rs17038164","1:118862669","C/T",0.65480000000000005,0.97,0.93,1.02,"-",0.2,7109,20883]
["rs6681426","rs2280078","1:150600181","C/T",0.6603,1,0.95,1.04,"-",0.91900000000000004,7106,20881]
["rs993925","rs993925","1:218860068","T/C",0.48830000000000001,1.04,1.01,1.07,"Yes",1.49E-2,10548,77367]
["rs6688537","rs891700","1:239881926","A/G",0.48749999999999999,1.02,0.98,1.07,"Yes",0.313,7094,20849]
["rs2571445","rs2571445","2:218683154","G/A",0.3886,1.03,0.99,1.08,"Yes",0.14599999999999999,7010,20539]
["rs10498230","rs10498230","2:229502503","T/C",0.84709999999999996,1.04,0.98,1.1100000000000001,"Yes",0.17100000000000001,7035,20737]
["rs61332075","rs75804782","2:239316043","C/T",0.9526,1,0.9,1.1100000000000001,"-",0.96899999999999997,7098,20859]
["rs12477314","rs12477314","2:239877148","T/C",0.73170000000000002,1.01,0.98,1.05,"Yes",0.57899999999999996,10515,77225]
["rs1529672","rs1529672","3:25520582","A/C",0.64959999999999996,1.03,0.99,1.06,"Yes",0.13900000000000001,10521,77295]
["rs1490265","rs4438669","3:67454943","A/G",0.38540000000000002,1.02,0.98,1.07,"Yes",0.38100000000000001,7087,20840]
["esv2660202","rs62275518","3:168731223","G/A",0.8216,1,0.94,1.06,"-",0.97499999999999998,7096,20865]
["rs1344555","rs1344555","3:169300219","C/T",0.71360000000000001,1.01,0.98,1.05,"Yes",0.56999999999999995,10514,77190]
["rs2045517","rs2045517","4:89870964","C/T",0.49330000000000002,1.08,1.03,1.1299999999999999,"Yes",7.7099999999999998E-4,7024,20636]
["rs34480284","rs7679673","4:106061534","A/C",0.1953,1.01,0.95,1.06,"Yes",0.80200000000000005,7095,20849]
["rs10516526","rs10516526","4:106688904","G/A",0.99980000000000002,1.88,0.22,16.39,"Yes",0.56599999999999995,7112,20893]
["rs34712979","rs34712979","4:106819053","G/A",1.1999999999999999E-3,0.98,0.47,2.0499999999999998,"No",0.95199999999999996,7105,20895]
["rs138641402","rs12504628","4:145436324","C/T",0.69610000000000005,1.1000000000000001,1.05,1.1499999999999999,"Yes",1E-4,7089,20833]
["rs1551943","rs1551943","5:52195033","G/A",0.1628,1.02,0.96,1.08,"Yes",0.53100000000000003,7104,20875]
["rs153916","rs153916","5:95036700","C/T",0.82179999999999997,1,0.94,1.07,"-",0.97599999999999998,3440,56456]
["rs7713065","rs3857440","5:131794069","G/A",0.36849999999999999,1.07,1.02,1.1100000000000001,"Yes",6.3899999999999998E-3,7104,20892]
["rs7715901","rs7733088","5:147856333","A/G",0.39589999999999997,1.03,0.99,1.08,"Yes",0.13,7109,20876]
["rs3839234","rs59032271","5:148618749","C/T",0.57350000000000001,1.06,1.01,1.1100000000000001,"No",1.0200000000000001E-2,7094,20887]
["rs10515750","rs10515750","5:156810072","C/T",5.9999999999999995E-4,0.33,0.1,1.08,"No",6.6299999999999998E-2,7114,20889]
["rs1990950","rs1990950","5:156920756","T/G",0.27010000000000001,1.03,0.98,1.08,"Yes",0.32100000000000001,7107,20895]
["rs6924424","rs9942510","6:7800306","G/A",2.3E-3,0.8,0.48,1.32,"-",0.375,7111,20897]
["rs34864796","rs7749305","6:27446566","T/C",1.5E-3,0.99,0.54,1.84,"No",0.98499999999999999,7108,20890]
["rs28986170","rs2516484","6:31496381","T/A",0.98919999999999997,1.21,0.96,1.52,"Yes",0.106,7105,20891]
["rs2857595","rs2857595","6:31568469","G/A",0.495,0.98,0.95,1.01,"No",0.29099999999999998,10547,77346]
["rs2070600","rs2070600","6:32151443","T/C",0.77600000000000002,1.1000000000000001,1.05,1.1599999999999999,"Yes",1.12E-4,7264,24917]
["rs114544105","rs9273529","6:32628698","C/T",0.1132,0.98,0.91,1.05,"No",0.58499999999999996,7102,20899]
["rs114229351","rs9275205","6:32657560","T/C",0.2291,0.98,0.94,1.04,"No",0.56000000000000005,7106,20888]
["rs141651520","rs13206405","6:73663814","A/C",0.78590000000000004,1.01,0.96,1.07,"Yes",0.60699999999999998,7106,20894]
["rs2768551","rs2768551","6:109270656","G/A",0.2616,1.01,0.96,1.06,"Yes",0.72,7096,20866]
["rs148274477","rs17280293","6:142688969","G/A",0.97589999999999999,1.1100000000000001,0.96,1.28,"Yes",0.17499999999999999,7108,20899]
["rs7753012","rs7776375","6:142777064","G/A",0.62780000000000002,1.04,1,1.0900000000000001,"Yes",6.4799999999999996E-2,7108,20900]
["rs10246303","rs2881756","7:7256440","C/T",0.9536,1,0.9,1.1100000000000001,"-",0.96399999999999997,7108,20904]
["rs7872188","rs10814852","9:4144772","C/T",0.1358,1,0.94,1.07,"-",0.97499999999999998,7098,20892]
["rs16909859","rs16909859","9:98204792","G/A",0.18790000000000001,0.98,0.93,1.03,"No",0.44400000000000001,7112,20896]
["rs10858246","rs12684650","9:139110654","C/T",0.14910000000000001,1.01,0.95,1.07,"-",0.84799999999999998,7105,20890]
["rs10870202","rs3923827","9:139251480","T/C",0.30549999999999999,1,0.95,1.05,"-",1,7095,20866]
["rs7090277","rs7068966","10:12277992","T/C",0.68869999999999998,1.02,0.99,1.06,"Yes",0.17599999999999999,10545,77361]
["rs3847402","rs4749516","10:30268579","C/T",0.88119999999999998,0.99,0.92,1.06,"No",0.747,7094,20850]
["rs7095607","rs7079481","10:69959242","C/A",0.214,1.01,0.96,1.07,"Yes",0.68799999999999994,7106,20888]
["rs2637254","rs2579747","10:78327759","C/T",0.40820000000000001,0.99,0.95,1.03,"No",0.64400000000000002,7077,20817]
["rs4237643","rs2862996","11:43653833","T/G",0.1653,1.07,1.01,1.1299999999999999,"Yes",2.6200000000000001E-2,7100,20875]
["rs2863171","rs11038359","11:45245538","G/T",0.99729999999999996,1.6,0.91,2.83,"Yes",0.10299999999999999,7112,20908]
["rs567508","rs541601","11:126009500","C/T",0.41260000000000002,1.02,0.97,1.06,"Yes",0.45700000000000002,7087,20781]
["rs11172113","rs11172113","12:57527283","C/T",0.76070000000000004,1.02,0.99,1.06,"Yes",0.23,10548,77357]
["rs1494502","rs4762095","12:65805908","T/C",0.43530000000000002,1.02,0.98,1.07,"Yes",0.36,7045,20781]
["rs113745635","rs11829776","12:95531442","T/C",0.14299999999999999,1.01,0.95,1.07,"Yes",0.8,7105,20859]
["rs12820313","rs4762630","12:96244409","G/A",0.874,0.95,0.89,1.02,"No",0.13600000000000001,7097,20866]
["rs10850377","rs11067283","12:115195891","A/T",0.96640000000000004,1.1299999999999999,1,1.28,"Yes",5.8700000000000002E-2,7104,20845]
["rs35506","rs10850434","12:115495279","G/A",0.5625,1.01,0.97,1.06,"No",0.66,7054,20765]
["rs7155279","rs7155279","14:92485881","T/G",0.66039999999999999,1.01,0.97,1.06,"Yes",0.64100000000000001,7079,20847]
["rs117068593","rs10498635","14:93103309","T/C",0.99760000000000004,1.1100000000000001,0.67,1.84,"Yes",0.69,7113,20915]
["rs10851839","rs1441358","15:71612514","T/G",0.27260000000000001,0.99,0.94,1.03,"No",0.55200000000000005,7103,20884]
["rs12149828","rs12325084","16:10718931","C/T",0.25679999999999997,1,0.95,1.05,"-",0.96899999999999997,7101,20856]
["rs12447804","rs12924215","16:58071092","C/T",0.3468,0.98,0.94,1.03,"No",0.41,7100,20875]
["rs1079572","rs12716850","16:78187903","A/G",0.50639999999999996,1,0.96,1.05,"-",0.85599999999999998,7105,20893]
["rs11658500","rs11658500","17:36886828","G/A",1.2999999999999999E-3,1.1399999999999999,0.61,2.11,"Yes",0.68700000000000006,7114,20909]
["rs6501431","rs12450399","17:68977068","G/A",1.7000000000000001E-2,1.07,0.91,1.27,"No",0.42,7108,20902]
["rs7218675","rs8064529","17:73519413","C/T",0.45190000000000002,0.97,0.93,1.02,"-",0.253,7089,20850]
["rs113473882","rs34093919","19:41117300","A/G",0.99990000000000001,1.24,0.13,12.11,"Yes",0.85199999999999998,7111,20914]
["rs6140050","rs2145272","20:6626218","A/G",0.12970000000000001,1.04,0.97,1.1100000000000001,"Yes",0.24099999999999999,7104,20893]
["rs72448466","rs6062506","20:62352389","T/G",0.35039999999999999,0.98,0.94,1.03,"No",0.50600000000000001,7109,20878]
["rs2834440","rs2834442","21:35690786","A/T",0.50129999999999997,1.01,0.96,1.05,"Yes",0.82299999999999995,7089,20869]
["rs134041","rs134110","22:28076058","C/T",8.2000000000000007E-3,1.1599999999999999,0.9,1.49,"Yes",0.25,7101,20869]
["rs2283847","rs2283847","22:28181399","C/T",0.37059999999999998,1.05,1.01,1.1000000000000001,"Yes",2.8199999999999999E-2,7098,20851]

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["a)      European ancestry"]
[{"$nulls":4},"eMR",null,null,null,"COPD case control",null,null,null,"LHS",null,null,null,"UK Biobank",null,null,null,"All"]
["Sentinel rsid","Proxy rsid","chr:position b37","Non/coded allele","OR","Lower 95% CI","Upper 95% CI","P","OR","Lower 95% CI","Upper 95% CI","P","OR","Lower 95% CI","Upper 95% CI","P","OR","Lower 95% CI","Upper 95% CI","P","Coded AF","OR","Lower 95% CI","Upper 95% CI","P"]
["rs2284746","rs2284746 ","1:17306675","C/G",0.87,0.74,1.03,0.10100000000000001,1.03,0.94,1.1399999999999999,0.498,1.0900000000000001,0.82,1.45,0.56499999999999995,1.05,0.94,1.18,0.36899999999999999,0.52549999999999997,1.02,0.95,1.08,0.64500000000000002]
["rs17513135","rs17513135 ","1:40035686","C/T",0.98,0.81,1.18,0.79800000000000004,1.03,0.92,1.1499999999999999,0.63,1.1000000000000001,0.8,1.52,0.54400000000000004,1.04,0.91,1.19,0.53600000000000003,0.2422,1.03,0.95,1.1100000000000001,0.47299999999999998]
["rs1192404","rs1192404 ","1:92068967","A/G",1.01,0.79,1.28,0.94299999999999995,1.05,0.92,1.2,0.45200000000000001,0.56999999999999995,0.36,0.91,1.8599999999999998E-2,0.96,0.83,1.1200000000000001,0.63500000000000001,0.16200000000000001,0.99,0.91,1.0900000000000001,0.84799999999999998]
["rs12140637","rs12140637 ","1:92374517","C/T",1.1499999999999999,0.96,1.38,0.128,1.05,0.95,1.17,0.36399999999999999,0.98,0.72,1.32,0.879,1.02,0.9,1.1499999999999999,0.78,0.31979999999999997,1.05,0.98,1.1299999999999999,0.18099999999999999]
["rs200154334","rs200154334 ","1:118862070","C/CAT",1.04,0.86,1.26,0.70199999999999996,1.07,0.95,1.2,0.251,1.01,0.73,1.4,0.95799999999999996,1.05,0.92,1.21,0.45300000000000001,0.75029999999999997,1.06,0.98,1.1399999999999999,0.17]
["rs6681426","rs6681426 ","1:150586971","G/A",0.95,0.8,1.1299999999999999,0.55100000000000005,1.04,0.94,1.1499999999999999,0.42399999999999999,0.83,0.62,1.1000000000000001,0.20100000000000001,1.0900000000000001,0.97,1.22,0.17,0.64900000000000002,1.03,0.96,1.1000000000000001,0.43]
["rs993925","rs993925 ","1:218860068","T/C",1.04,0.88,1.25,0.625,1.05,0.94,1.1599999999999999,0.39100000000000001,1.0900000000000001,0.81,1.48,0.56200000000000006,0.95,0.85,1.07,0.41799999999999998,0.65849999999999997,1.02,0.95,1.0900000000000001,0.67200000000000004]
["rs4328080","rs4328080 ","1:219963088","A/G",1.08,0.91,1.28,0.36099999999999999,0.98,0.88,1.08,0.66600000000000004,1.1000000000000001,0.82,1.47,0.54100000000000004,0.97,0.86,1.1000000000000001,0.65700000000000003,0.39179999999999998,1,0.93,1.07,0.97499999999999998]
["rs6688537","rs6688537 ","1:239850588","C/A",1.01,0.86,1.19,0.91400000000000003,1.02,0.92,1.1200000000000001,0.73899999999999999,0.98,0.73,1.3,0.86199999999999999,1,0.89,1.1299999999999999,0.95399999999999996,0.50729999999999997,1.01,0.94,1.08,0.79500000000000004]
["rs62126408","rs62126408 ","2:18309132","C/T",0.93,0.74,1.18,0.56000000000000005,1.1000000000000001,0.96,1.26,0.17100000000000001,0.8,0.55000000000000004,1.1599999999999999,0.248,0.99,0.83,1.17,0.89500000000000002,0.86119999999999997,1.02,0.93,1.1200000000000001,0.73499999999999999]
["rs1430193","rs1430193 ","2:56120853","A/T",0.96,0.8,1.1499999999999999,0.65900000000000003,0.93,0.84,1.03,0.16500000000000001,0.89,0.66,1.21,0.46800000000000003,1.02,0.9,1.1499999999999999,0.74099999999999999,0.35410000000000003,0.96,0.9,1.03,0.27600000000000002]
["rs2571445","rs2571445 ","2:218683154","G/A",1.03,0.87,1.22,0.73799999999999999,0.96,0.87,1.06,0.46400000000000002,1.04,0.78,1.38,0.79,1.02,0.91,1.1399999999999999,0.79300000000000004,0.40620000000000001,1,0.93,1.06,0.88400000000000001]
["rs10498230","rs10498230 ","2:229502503","T/C",1.36,0.99,1.86,6.0600000000000001E-2,0.97,0.8,1.19,0.80200000000000005,"-","-","-","-",0.97,0.78,1.2,0.754,0.93120000000000003,1.03,0.9,1.18,0.66800000000000004]
["rs61332075","rs61332075 ","2:239316560","C/G",1.03,0.79,1.35,0.80500000000000005,0.91,0.78,1.06,0.214,"-","-","-","-",1.01,0.84,1.2,0.95299999999999996,0.88719999999999999,0.96,0.86,1.07,0.46300000000000002]
["rs12477314","rs12477314 ","2:239877148","T/C",0.91,0.74,1.1200000000000001,0.37,0.97,0.86,1.1000000000000001,0.65100000000000002,"-","-","-","-",0.95,0.82,1.1000000000000001,0.52300000000000002,0.80610000000000004,0.96,0.88,1.04,0.29099999999999998]
["rs1529672","rs1529672 ","3:25520582","A/C",1.02,0.82,1.28,0.85099999999999998,1.06,0.93,1.21,0.374,1.22,0.81,1.83,0.34200000000000003,0.97,0.83,1.1299999999999999,0.67900000000000005,0.83750000000000002,1.03,0.94,1.1299999999999999,0.52400000000000002]
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["rs12447804","rs12447804 ","16:58075282","C/T",1,0.28999999999999998,3.4,0.998,0.94,0.83,1.06,0.30499999999999999,0.99,0.7,1.4,0.94499999999999995,1,0.87,1.1499999999999999,0.97099999999999997,0.21729999999999999,0.97,0.89,1.06,0.46100000000000002]
["rs3743609","rs3743609 ","16:75467021","G/C",0.9,0.76,1.06,0.20200000000000001,1,0.91,1.1100000000000001,0.97799999999999998,0.92,0.69,1.22,0.56299999999999994,0.99,0.88,1.1100000000000001,0.83499999999999996,0.59709999999999996,0.97,0.91,1.04,0.45400000000000001]
["rs1079572","rs1079572 ","16:78187138","G/A",0.97,0.82,1.1399999999999999,0.70399999999999996,0.99,0.9,1.1000000000000001,0.91700000000000004,0.8,0.6,1.06,0.115,1.03,0.91,1.1599999999999999,0.65900000000000003,0.58450000000000002,0.99,0.92,1.06,0.72799999999999998]
["rs59835752","rs62070270 ","17:28263980","A/G",0.95,0.81,1.1200000000000001,0.54,0.96,0.87,1.05,0.36899999999999999,"-","-","-","-","-","-","-","-",0.4662,0.95,0.88,1.04,0.27800000000000002]
["rs11658500","rs11658500 ","17:36886828","G/A",1.04,0.81,1.33,0.75700000000000001,1.0900000000000001,0.95,1.25,0.23300000000000001,1.1000000000000001,0.74,1.63,0.64700000000000002,0.96,0.82,1.1200000000000001,0.59199999999999997,0.1459,1.03,0.94,1.1399999999999999,0.47499999999999998]
["rs35524223","rs200566278 ","17:44212521","T/TG",0.98,0.8,1.2,0.84,"-","-","-","-","-","-","-","-","-","-","-","-",0.22109999999999999,0.98,0.8,1.2,0.84]
["rs6501431","rs6501431 ","17:68976415","T/C",1.25,1.02,1.53,3.4000000000000002E-2,1.05,0.94,1.18,0.39200000000000002,1.01,0.72,1.42,0.95399999999999996,1.03,0.89,1.18,0.69099999999999995,0.21460000000000001,1.07,0.99,1.1599999999999999,9.8799999999999999E-2]
["rs7218675","rs7218675 ","17:73513185","C/A",1.03,0.86,1.24,0.74099999999999999,1.1000000000000001,0.99,1.23,7.9500000000000001E-2,1.28,0.92,1.78,0.14099999999999999,0.97,0.85,1.1100000000000001,0.67600000000000005,0.71689999999999998,1.06,0.98,1.1399999999999999,0.153]
["rs113473882","rs113473882 ","19:41124155","C/T",0.54,0.16,1.85,0.32700000000000001,1.1000000000000001,0.69,1.76,0.68600000000000005,0.95,0.24,3.82,0.94699999999999995,1.64,0.93,2.9,8.5699999999999998E-2,0.98799999999999999,1.19,0.85,1.67,0.30399999999999999]
["rs6140050","rs6140050 ","20:6632901","A/C",1,0.84,1.19,0.997,1.05,0.95,1.17,0.317,1.21,0.91,1.62,0.184,1.05,0.93,1.18,0.41199999999999998,0.36609999999999998,1.05,0.98,1.1299999999999999,0.14299999999999999]
["rs72448466","rs72448466 ","20:62363640","CGT/C",0.96,0.8,1.1599999999999999,0.67,0.89,0.8,0.99,3.4000000000000002E-2,"-","-","-","-",0.9,0.8,1.02,9.7900000000000001E-2,0.68589999999999995,0.91,0.84,0.98,8.4399999999999996E-3]
["rs2834440","rs2834440 ","21:35690499","A/G",1.06,0.9,1.26,0.48899999999999999,1.08,0.98,1.19,0.13700000000000001,0.76,0.56000000000000005,1.03,0.08,0.96,0.86,1.08,0.54600000000000004,0.3911,1.02,0.95,1.0900000000000001,0.58899999999999997]
["rs11704827","rs11704827 ","22:18450287","T/A",0.91,0.75,1.1000000000000001,0.32,0.96,0.85,1.08,0.502,1.07,0.76,1.51,0.69399999999999995,0.91,0.79,1.04,0.17299999999999999,0.77939999999999998,0.94,0.87,1.02,0.122]
["rs134041","rs134041 ","22:28056338","C/T",1.05,0.9,1.24,0.52300000000000002,0.99,0.9,1.1000000000000001,0.90100000000000002,1.35,1.02,1.8,3.5700000000000003E-2,1.02,0.91,1.1399999999999999,0.747,0.44540000000000002,1.03,0.96,1.1000000000000001,0.39700000000000002]
["rs2283847","rs2283847 ","22:28181399","C/T",1.08,0.92,1.27,0.36,1.03,0.94,1.1399999999999999,0.50800000000000001,1.1000000000000001,0.83,1.47,0.498,1.02,0.91,1.1499999999999999,0.69099999999999995,0.56210000000000004,1.04,0.97,1.1100000000000001,0.22800000000000001]
[]
[]
["b)      Chinese ancestry (CKB)"]
[]
["Sentinel rsid","Proxy rsid","chr:position b37","Non/coded allele","Effect allele freq","OR","Lower 95% CI","Upper 95% CI","P","N cases","N controls"]
["rs2284746","rs2284746","1:17306675","C/G",0.27710000000000001,1.03,0.96,1.1000000000000001,0.443,5344,5201]
["rs17513135","rs4660293","1:40028180","A/G",0.11609999999999999,0.97,0.85,1.1100000000000001,0.64200000000000002,5277,1817]
["rs1192404","rs1192415","1:92077097","A/G",0.1411,1.04,0.91,1.18,0.58299999999999996,5285,1824]
["rs200154334","rs17038164","1:118862669","C/T",0.6522,0.99,0.9,1.0900000000000001,0.81799999999999995,5289,1820]
["rs6681426","rs2280078","1:150600181","C/T",0.65549999999999997,0.94,0.86,1.03,0.21,5284,1822]
["rs993925","rs993925","1:218860068","T/C",0.49299999999999999,0.95,0.89,1.01,7.5200000000000003E-2,5345,5203]
["rs6688537","rs891700","1:239881926","A/G",0.48770000000000002,0.96,0.88,1.05,0.42299999999999999,5276,1818]
["rs2571445","rs2571445","2:218683154","G/A",0.38979999999999998,0.93,0.85,1.02,0.11,5218,1792]
["rs10498230","rs10498230","2:229502503","T/C",0.85640000000000005,0.97,0.85,1.0900000000000001,0.58099999999999996,5225,1810]
["rs61332075","rs75804782","2:239316043","C/T",0.95269999999999999,0.95,0.77,1.17,0.628,5281,1817]
["rs12477314","rs12477314","2:239877148","T/C",0.7298,0.97,0.9,1.03,0.312,5319,5196]
["rs1529672","rs1529672","3:25520582","A/C",0.65339999999999998,1.03,0.97,1.1000000000000001,0.30099999999999999,5332,5189]
["rs1490265","rs4438669","3:67454943","A/G",0.38990000000000002,1.04,0.95,1.1399999999999999,0.39100000000000001,5272,1815]
["esv2660202","rs62275518","3:168731223","G/A",0.8206,1,0.89,1.1200000000000001,1,5281,1815]
["rs1344555","rs1344555","3:169300219","C/T",0.71730000000000005,1.1000000000000001,1.03,1.17,5.7400000000000003E-3,5320,5194]
["rs2045517","rs2045517","4:89870964","C/T",0.50309999999999999,1.03,0.95,1.1299999999999999,0.44900000000000001,5228,1796]
["rs34480284","rs7679673","4:106061534","A/C",0.19739999999999999,1.0900000000000001,0.97,1.21,0.14499999999999999,5275,1820]
["rs10516526","rs10516526","4:106688904","G/A",0.99990000000000001,"-","-","-","-","-","-"]
["rs34712979","rs34712979","4:106819053","G/A",6.9999999999999999E-4,2.11,0.35,12.61,0.41299999999999998,5284,1821]
["rs138641402","rs12504628","4:145436324","C/T",0.71640000000000004,0.98,0.89,1.08,0.72499999999999998,5274,1815]
["rs1551943","rs1551943","5:52195033","G/A",0.17119999999999999,1.04,0.92,1.1599999999999999,0.55400000000000005,5282,1822]
["rs153916","rs153916","5:95036700","C/T",0.82169999999999999,0.68,0.44,1.06,8.9599999999999999E-2,59,3381]
["rs7713065","rs3857440","5:131794069","G/A",0.36799999999999999,1.03,0.94,1.1299999999999999,0.51200000000000001,5285,1819]
["rs7715901","rs7733088","5:147856333","A/G",0.39660000000000001,0.94,0.86,1.03,0.188,5288,1821]
["rs3839234","rs59032271","5:148618749","C/T",0.59460000000000002,0.98,0.9,1.07,0.69899999999999995,5276,1818]
["rs10515750","rs10515750","5:156810072","C/T",2.9999999999999997E-4,"-","-","-","-","-","-"]
["rs1990950","rs1990950","5:156920756","T/G",0.26779999999999998,1.07,0.97,1.17,0.20499999999999999,5284,1823]
["rs6924424","rs9942510","6:7800306","G/A",1.6000000000000001E-3,2.5099999999999998,0.69,9.14,0.16200000000000001,5289,1822]
["rs34864796","rs7749305","6:27446566","T/C",1.1000000000000001E-3,0.33,0.1,1.07,6.54E-2,5285,1823]
["rs28986170","rs2516484","6:31496381","T/A",0.99160000000000004,1.47,0.94,2.29,8.7999999999999995E-2,5286,1819]
["rs2857595","rs2857595","6:31568469","G/A",0.51800000000000002,0.97,0.92,1.03,0.34499999999999997,5346,5201]
["rs2070600","rs2070600","6:32151443","T/C",0.77639999999999998,0.87,0.79,0.96,7.9600000000000001E-3,5265,1999]
["rs114544105","rs9273529","6:32628698","C/T",9.8699999999999996E-2,0.97,0.84,1.1200000000000001,0.69899999999999995,5281,1821]
["rs114229351","rs9275205","6:32657560","T/C",0.22289999999999999,0.98,0.88,1.08,0.65200000000000002,5286,1820]
["rs141651520","rs13206405","6:73663814","A/C",0.77780000000000005,1.04,0.94,1.1599999999999999,0.41799999999999998,5284,1822]
["rs2768551","rs2768551","6:109270656","G/A",0.26500000000000001,1.03,0.93,1.1399999999999999,0.58499999999999996,5276,1820]
["rs148274477","rs17280293","6:142688969","G/A",0.97899999999999998,0.92,0.67,1.25,0.57799999999999996,5287,1821]
["rs7753012","rs7776375","6:142777064","G/A",0.62990000000000002,0.96,0.88,1.05,0.38300000000000001,5286,1822]
["rs10246303","rs2881756","7:7256440","C/T",0.95420000000000005,1.1200000000000001,0.92,1.37,0.26800000000000002,5288,1820]
["rs7872188","rs10814852","9:4144772","C/T",0.1338,1.01,0.89,1.1499999999999999,0.84399999999999997,5279,1819]
["rs16909859","rs16909859","9:98204792","G/A",0.18640000000000001,1.01,0.9,1.1299999999999999,0.90300000000000002,5289,1823]
["rs10858246","rs12684650","9:139110654","C/T",0.14760000000000001,1.07,0.94,1.21,0.315,5285,1820]
["rs10870202","rs3923827","9:139251480","T/C",0.30599999999999999,0.94,0.86,1.04,0.219,5278,1817]
["rs7090277","rs7068966","10:12277992","T/C",0.69850000000000001,0.99,0.93,1.06,0.77,5341,5204]
["rs3847402","rs4749516","10:30268579","C/T",0.88149999999999995,1.02,0.9,1.17,0.73799999999999999,5273,1821]
["rs7095607","rs7079481","10:69959242","C/A",0.21190000000000001,1.01,0.91,1.1200000000000001,0.88200000000000001,5284,1822]
["rs2637254","rs2579747","10:78327759","C/T",0.40899999999999997,1,0.91,1.0900000000000001,0.96899999999999997,5257,1820]
["rs4237643","rs2862996","11:43653833","T/G",0.17280000000000001,0.94,0.84,1.05,0.27700000000000002,5280,1820]
["rs2863171","rs11038359","11:45245538","G/T",0.99890000000000001,1.74,0.56000000000000005,5.43,0.34200000000000003,5290,1822]
["rs567508","rs541601","11:126009500","C/T",0.41489999999999999,1.02,0.94,1.1200000000000001,0.60099999999999998,5273,1814]
["rs11172113","rs11172113","12:57527283","C/T",0.76639999999999997,1,0.93,1.07,0.97699999999999998,5346,5202]
["rs1494502","rs4762095","12:65805908","T/C",0.43680000000000002,1.0900000000000001,1,1.19,6.1400000000000003E-2,5226,1819]
["rs113745635","rs11829776","12:95531442","T/C",0.14630000000000001,1.1000000000000001,0.97,1.25,0.11899999999999999,5287,1818]
["rs12820313","rs4762630","12:96244409","G/A",0.87450000000000006,1.04,0.91,1.19,0.54500000000000004,5280,1817]
["rs10850377","rs11067283","12:115195891","A/T",0.96879999999999999,0.94,0.72,1.21,0.61399999999999999,5284,1820]
["rs35506","rs10850434","12:115495279","G/A",0.55940000000000001,1.02,0.93,1.1100000000000001,0.74299999999999999,5240,1814]
["rs7155279","rs7155279","14:92485881","T/G",0.66200000000000003,1.1000000000000001,1,1.2,5.1999999999999998E-2,5259,1820]
["rs117068593","rs10498635","14:93103309","T/C",0.99839999999999995,0.28999999999999998,0.08,1.03,5.62E-2,5289,1824]
["rs10851839","rs1441358","15:71612514","T/G",0.27629999999999999,1.01,0.91,1.1100000000000001,0.92,5283,1820]
["rs12149828","rs12325084","16:10718931","C/T",0.25919999999999999,0.99,0.9,1.0900000000000001,0.82599999999999996,5281,1820]
["rs12447804","rs12924215","16:58071092","C/T",0.34510000000000002,1.04,0.95,1.1399999999999999,0.442,5280,1820]
["rs1079572","rs12716850","16:78187903","A/G",0.51019999999999999,0.98,0.9,1.07,0.67,5285,1820]
["rs11658500","rs11658500","17:36886828","G/A",1.1999999999999999E-3,2.42,0.54,10.96,0.25,5290,1824]
["rs6501431","rs12450399","17:68977068","G/A",1.7100000000000001E-2,0.87,0.62,1.2,0.39200000000000002,5287,1821]
["rs7218675","rs8064529","17:73519413","C/T",0.44519999999999998,1.05,0.96,1.1399999999999999,0.31900000000000001,5269,1820]
["rs113473882","rs34093919","19:41117300","A/G",0.99990000000000001,"-","-","-","-","-","-"]
["rs6140050","rs2145272","20:6626218","A/G",0.12620000000000001,1,0.87,1.1399999999999999,0.98199999999999998,5282,1822]
["rs72448466","rs6062506","20:62352389","T/G",0.34870000000000001,1.05,0.96,1.1499999999999999,0.307,5287,1822]
["rs2834440","rs2834442","21:35690786","A/T",0.50229999999999997,1.02,0.93,1.1100000000000001,0.74,5269,1820]
["rs134041","rs134110","22:28076058","C/T",7.4000000000000003E-3,1.02,0.62,1.68,0.94099999999999995,5282,1819]
["rs2283847","rs2283847","22:28181399","C/T",0.37459999999999999,0.97,0.88,1.06,0.46600000000000003,5277,1821]