SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

The elusive nature and diagnostics of misfolded Aβ oligomers.

Cerasoli, E; Ryadnov, MG; Austen, BM (2015) The elusive nature and diagnostics of misfolded Aβ oligomers. Front Chem, 3. p. 17. https://doi.org/10.3389/fchem.2015.00017
SGUL Authors: Austen, Brian Maxwell

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (453kB) | Preview

Abstract

Amyloid-beta (Aβ) peptide oligomers are believed to be the causative agents of Alzheimer's disease (AD). Though post-mortem examination shows that insoluble fibrils are deposited in the brains of AD patients in the form of intracellular (tangles) and extracellular (plaques) deposits, it has been observed that cognitive impairment is linked to synaptic dysfunction in the stages of the illness well before the appearance of these mature deposits. Increasing evidence suggests that the most toxic forms of Aβ are soluble low-oligomer ligands whose amounts better correlate with the extent of cognitive loss in patients than the amounts of fibrillar insoluble forms. Therefore, these ligands hold the key to a better understanding of AD prompting the search for clearer correlations between their structure and toxicity. The importance of such correlations and their diagnostic value for the early diagnosis of AD is discussed here with a particular emphasis on the transient nature and structural plasticity of misfolded Aβ oligomers.

Item Type: Article
Additional Information: Copyright © 2015 Cerasoli, Ryadnov and Austen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Alzheimer's disease, Aβ oligomers, fibrillogenesis, neurodegeneration, protein misfolding, A beta oligomers, neurodegeneration, protein misfolding, fibrillogenesis, Alzheimer's disease
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Front Chem
Language: eng
Dates:
DateEvent
19 March 2015Published
24 February 2015Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 25853119
Web of Science ID: WOS:000373354200001
Go to PubMed abstract
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/108340
Publisher's version: https://doi.org/10.3389/fchem.2015.00017

Actions (login required)

Edit Item Edit Item