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Clinical review: Biomarkers of acute kidney injury: where are we now?

Ostermann, M; Philips, BJ; Forni, LG (2012) Clinical review: Biomarkers of acute kidney injury: where are we now? Critical Care, 16 (233). ISSN 1364-8535 https://doi.org/10.1186/cc11380
SGUL Authors: Philips, Barbara

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Abstract

The recognition that acute kidney injury (AKI) is a significant independent risk factor for morbidity and mortality has resulted in a substantial number of publications over the past 5 years or more. In no small part these have, to a degree, highlighted the inadequacy of conventional markers of renal insufficiency in the acute setting. Much effort has been invested in the identification of early, specific AKI markers in order to aid early diagnosis of AKI and hopefully improve outcome. The search for a 'biomarker' of AKI has seen early promise replaced by a degree of pessimism due to the lack of a clear candidate molecule and variability of results. We outline the major studies described to date as well as discuss potential reasons for the discrepancies observed and suggest that evolution of the field may result in success with ultimately an improvement in patient outcomes.

Item Type: Article
Additional Information: ©2012 BioMed Central Ltd made available here with permission from the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Critical Care Medicine, General & Internal Medicine, CRITICAL CARE MEDICINE, GELATINASE-ASSOCIATED LIPOCALIN, ACUTE-RENAL-FAILURE, CRITICALLY-ILL PATIENTS, ADULT CARDIAC-SURGERY, INTENSIVE-CARE-UNIT, SERUM CYSTATIN-C, DELAYED GRAFT FUNCTION, ACID-BINDING PROTEIN, URINARY BIOMARKERS, CARDIOPULMONARY BYPASS, 11 Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Critical Care
ISSN: 1364-8535
Language: eng
Dates:
DateEvent
21 September 2012Published
PubMed ID: 23014769
Web of Science ID: WOS:000317499900070
Go to PubMed abstract
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/107249
Publisher's version: https://doi.org/10.1186/cc11380

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