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Lifecourse social position and d-dimer; findings from the 1958 british birth cohort.

Tabassum, F; Kumari, M; Rumley, A; Power, C; Strachan, DP; Lowe, G (2014) Lifecourse social position and d-dimer; findings from the 1958 british birth cohort. PLoS One, 9 (5). e93277 (1)- e93277 (8). ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0093277
SGUL Authors: Strachan, David Peter

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Abstract

The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers.

Item Type: Article
Additional Information: Copyright: 2014 Tabassum et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: General Science & Technology, MD Multidisciplinary
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: PLoS One
ISSN: 1932-6203
Related URLs:
Dates:
DateEvent
8 May 2014Published
PubMed ID: 24809471
Web of Science ID: 24809471
Go to PubMed abstract
URI: http://sgultest.da.ulcc.ac.uk/id/eprint/107061
Publisher's version: https://doi.org/10.1371/journal.pone.0093277

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