Burn, J;
Gerdes, AM;
Macrae, F;
Mecklin, JP;
Moeslein, G;
Olschwang, S;
Eccles, D;
Evans, DG;
Maher, ER;
Bertario, L;
et al.
Burn, J; Gerdes, AM; Macrae, F; Mecklin, JP; Moeslein, G; Olschwang, S; Eccles, D; Evans, DG; Maher, ER; Bertario, L; Bisgaard, ML; Dunlop, MG; Ho, JW; Hodgson, SV; Lindblom, A; Lubinski, J; Morrison, PJ; Murday, V; Ramesar, R; Side, L; Scott, RJ; Thomas, HJ; Vasen, HF; Barker, G; Crawford, G; Elliott, F; Movahedi, M; Pylvanainen, K; Wijnen, JT; Fodde, R; Lynch, HT; Mathers, JC; Bishop, DT; CAPP2 Investigators
(2011)
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.
Lancet, 378 (9809).
2081 - 2087.
https://doi.org/10.1016/S0140-6736(11)61049-0
SGUL Authors: Hodgson, Shirley Victoria
Abstract
Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint. The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer; we now report long-term follow-up of participants randomly assigned to aspirin or placebo.
Item Type: |
Article
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Additional Information: |
PMCID: PMC3243929 |
Keywords: |
Adenoma, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Chemoprevention, Colorectal Neoplasms, Hereditary Nonpolyposis, Dietary Carbohydrates, Double-Blind Method, Heterozygote, Humans, Starch |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS) |
Journal or Publication Title: |
Lancet |
Dates: |
Date | Event |
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17 December 2011 | Published |
|
PubMed ID: |
22036019 |
Web of Science ID: |
22036019 |
|
Download EPMC Full text (HTML)
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Go to PubMed abstract |
URI: |
http://sgultest.da.ulcc.ac.uk/id/eprint/101069 |
Publisher's version: |
https://doi.org/10.1016/S0140-6736(11)61049-0 |
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